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Oral finasteride remains the most clinically validated medication for androgenic alopecia (AGA). Over 20 years of trials and follow-up data show consistent, predictable outcomes in slowing miniaturization and restoring density, particularly in the vertex and mid-scalp.

Yet, despite this wealth of data, online forums and “miracle” before-and-after photos often distort expectations. These transformations represent the upper end of the response curve, while most users experience more moderate, steady results that unfold over months to years.

This article explores what realistic regrowth looks like with oral finasteride, how to interpret finasteride before and after photos critically, and what to expect when used correctly and consistently. 

What is Oral Finasteride?

Oral finasteride is a type II 5ɑ-reductase inhibitor that reduces the conversion of testosterone to dihydrotestosterone (DHT), the key androgen responsible for hair follicle miniaturization in AGA. 

Originally approved by the FDA at a dose of 1 mg for male pattern hair loss, oral finasteride has since become widely known as the gold-standard treatment for hair loss. Its primary mechanism is systemic DHT suppression, lowering circulating levels by roughly 60-70% and scalp DHT by up to 65%.^[1]Caserini, M., Radicioni, M., Leuratti, C., Terragni, E., Iorizzo, M., Palmieri, R. (2016). Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men … Continue reading

Mechanism of Action

As mentioned above, finasteride is a competitive inhibitor of the 5ɑ-reductase enzyme, specifically targeting the type II (and to a lesser extent, type III) isoenzymes.^[2]Zito, P.M., Bistas, K.G., Patel, P., Syed, K. (2024). Finasteride. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513329/

Treatment with finasteride leads to a significant decrease in both scalp and serum DHT concentrations. This effect is dose-dependent and has been observed as early as 28 days after starting treatment.^[3]Dallob, A.L., Sadick, N.S., Unger, W., Lipert, S., Geissler, L.A., Gregoire, S.L., Nguyen, H.H., Moore, E.C., Tanaka, W.K. (1994). The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp … Continue reading Lower DHT levels in the scalp prevent androgen-dependent miniaturization of hair follicles, promoting the maintenance and improvement of hair follicle size and number in the anagen (growth) phase.

Unlike topical formulations, oral finasteride exerts a systemic effect. More comprehensive, but also more likely to cause side effects in sensitive individuals.

Adverse Effects

The most commonly reported adverse effects of oral finasteride are sexual in nature, including decreased libido, erectile dysfunction, and reduced ejaculatory volume. These occur in a range of users depending on the study and determination of what a side effect is (<1% to 25%).^[4]Traish, A.M., Hassani, J., Guay, A.T., Zitzmann, M., Hansen, M.L. (2011). Adverse side effects of 5ɑ-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and … Continue reading 

Other potential side effects include psychological and neuropsychiatric effects and post-finasteride syndrome (PFS). PFS refers to persistent sexual, neurological, and physical symptoms that continue after stopping finasteride. However, the existence and prevalence of PFS are debated, with some studies suggesting a possible genetic predisposition.^[5]Gupta, A.K., Talukder, M., Keene, S.A., Bamimore, M.A. (2025). Is the safety of finasteride correlated with its route of administration: topical versus oral? A pharmacovigilance study with data from … Continue reading 

You can read in more depth about the potential side effects in our oral finasteride ultimate guide.

Why Expectation Setting Matters

Finasteride is powerful and predictable, but even the best data can get lost when you see incredible results online. Online before-and-after posts tend to showcase outliers, individuals who happen to respond at the extreme high end of the efficacy curve. 

Meanwhile, clinical averages show that:

• Most men stop or reverse their hair loss progression.
• Around 65-80% experience visible thickening after 12-24 months.
• Only a small subset achieves “complete restoration”.

Unrealistic expectations can lead to disappointment, early discontinuation, or cycling through treatments unnecessarily. Grounding expectations in clinical probabilities rather than forum anecdotes helps users stay consistent long enough to see results. 

What’s Possible ≠ What’s Probable

While oral finasteride can produce impressive regrowth, most users experience gradual thickening and stabilization rather than dramatic restoration. 

Treatment outcomes typically follow a distribution pattern:

• A minority are “hyper responders”, achieving rapid and substantial visible improvement.
• The majority notice moderate, progressive gains, such as fuller density or slowed shedding.
• A smaller subset experience arrest of hair loss but remain unsatisfied with new hair growth.^[6]Dhurat, R., Mathapati, S. (2015). Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy. Indian Journal of Dermatology. 60(3). 260-263. … Continue reading 

Factors influencing response:

• Age and duration of hair loss: Finasteride efficacy is higher in younger patients and those with less advanced disease at treatment initiation.^[7]Camacho, F.M., Garcia-Hernandez, M.J., Fernandez-Crehuet, J.L. (2008). Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: better response in patients under … Continue reading Starting treatment at age 40 or higher is an independent risk factor for insufficient efficacy.^[8]Yoshitake, T., Takeda, A., Ohki, K., Inoue, Y., Yamawaki, T., Otsuka, S., Akimoto, M., Nemoto, M., Shimakura, Y., Sato, A. (2015). Five-year efficacy of finasteride in 801 Japanese men with … Continue reading 

• Consistency: Missing doses or cycling off can interrupt the stabilization of hair loss.

• Adjunct therapies: Combining finasteride with other therapies like topical minoxidil can improve results.^[9]Hu, R., Xu, F., Sheng, Y., Qi, S., Han, Y., Miao, Y., Rui, W., Yang, Q. (2015). Combined treatment with oral finasteride and topical minoxidil in male androgenetic alopecia: a randomized and … Continue reading 
• Genetics: Variations in the androgen receptor (AR) gene sensitivity affect responsiveness.^[10]Keene, S., Goren A. (2011). Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with androgenetic alopecia mediated by epigenetics. Dermatologic … Continue reading 

Strong Evidence = Predictable Results

Unlike many newer (and even potentially stronger acting treatments), oral finasteride benefits from decades of standardized data, making outcomes highly predictable. A good example of this is comparing finasteride to dutasteride. Finasteride is extremely well-studied; therefore, we can usually predict the type of results we will see. Dutasteride, on the other hand, has studies showing it can outperform even the likes of finasteride in terms of hair regrowth. But the number of clinical studies is lacking, meaning that it is more difficult to predict a consistent outcome.

This predictability helps clinicians set clear, realistic expectations and provides users with confidence that consistency will lead to steady results.

Real Case Studies: Oral Finasteride Before and After

The examples below help see what’s possible and do not represent what every user should expect. They are purely anecdotal and not independently verified by us or any qualified third party.

Case Summary #1: Male (23), 3 Months on Oral Finasteride 1 mg (then every other day) + Topical Minoxidil Foam (twice daily)

This 23-year-old male took oral finasteride 1 mg daily for 2 months before titrating down to 1 mg every other day due to side effects. He also applied topical minoxidil foam twice daily, initially to the whole scalp but later exclusively to the hairline. He noted an initial shedding phase and early side effects on finasteride in the first month of treatment. In the second month, he described visible thickening while still on 1 mg daily. By month 3, he reduced finasteride to every other day and continued with minoxidil to maintain the progress. He reported marked improvement in hairline and density over the 3 months. 

The user also described early transient effects, including testicular ache (first week), watery semen, heightened libido, and less intense orgasm, which resolved after dialing the finasteride down to every other day. 

Case Summary #2: Male (25), 1-Year Course of Finasteride (1 mg) + Topical Minoxidil (1–2x Daily) + Monthly Dermarolling

This male Redditor started treatment at age 24 after severe crown thinning since he was about 18. His one-year course consisted of finasteride 1 mg daily (generic), topical liquid minoxidil 1–2/day, and dermarolling roughly monthly (post-shower, before nightly minoxidil). He supplemented with vitamin D and occasional biotin, and he regularly used argan oil after showers to limit flaking.

The patient noted a strong early response, but felt his results peaked roughly halfway into treatment. He stopped minoxidil for 1 month and missed some doses in the months leading up to the post. His photos indicated a significant improvement in density compared to baseline, particularly at the hairline and the top. He noted more coverage at the crown but felt it was still noticeably weaker than desired. The patient reported no sexual side effects or skin issues.

Case Summary #3: Male (24), 6 Months on Oral Finasteride 1 mg Daily + Oral Minoxidil 2.5 mg Daily

This 24-year-old male’s intervention consisted of oral finasteride 1 mg once daily and oral minoxidil 2.5 mg once daily. The user noted the emergence of small baby hairs at the hairline and temples at month 2 of treatment. By months 4-5, he reported noticeable thickening, with longer eyelashes and denser eyebrows. By month 6, the user showed clear improvement, as evidenced by his wet-hair photos and day-to-day density. He reported visible density gains at the hairline with better coverage under bright light, with his crown improved from baseline, though not fully closed. He reported no side effects, apart from brief mild erectile difficulty early on that resolved. 

Case Summary #4: Male (25), 3 Months on Oral Finasteride 1 mg Daily + Oral Minoxidil 2.5 mg Daily (added at month 2) + Ketoconazole Shampoo 3x/week + Microneedling 1.5 mm Weekly 

This 24-year-old male’s intervention was oral finasteride 1 mg daily for 3 months, oral minoxidil 2.5 mg daily (added 2 weeks before the 3-month update), ketoconazole shampoo (Nizoral) about three times weekly, and dermaroller 1.5 mm once weekly over the whole scalp.

The user described gradual thickening over the 3-month finasteride course, with minoxidil introduced at month 2.5. He reported a noticeable improvement in density at the hairline and mid-scalp compared with baseline. He described a possible mild libido reduction on finasteride and thinning of the eyebrows thinned on finasteride, which appeared fuller after starting minoxidil. He reported no other significant effects. 

Case Summary #5: Male (38), 7 Months on Oral Finasteride + Topical Finasteride + Topical Minoxidil + Weekly Microneedling

This 38-year-old male started the current treatment with oral finasteride 1 mg daily and topical minoxidil (strength/frequency not specified). He added topical finasteride (concentration not specified) and weekly microneedling at 0.25 mm in month 5. The patient reported a slight but noticeable improvement vs. baseline at month 5 and, at month 7, likewise described his progress as modest. In the 7 months, he achieved stabilization with modest density improvement, most visible anteriorly, with the crown remaining limited. He reported no side effects from finasteride and minoxidil. 

Case Summary #6: Male (28), 10 Years on Oral Finasteride + 4–5 Months on Oral Minoxidil 

This 28-year-old male reported on his 10-year treatment progress on oral finasteride 1 mg daily, before adding oral minoxidil 2.5 mg twice daily 4-5 months before the progress report. He confirmed no dermarolling or topical agent application. The patient reported that, between the ages of 18 and 27, he was on finasteride monotherapy, achieving significant regrowth and strong maintenance. Towards the end of that period, he reported subtle renewed thinning, prompting him to add oral minoxidil. Within 4 months thereafter, his hair density and thickness nearly doubled. 

He reported good tolerance to finasteride with no noticeable side effects. He added that oral minoxidil caused mild generalized hypertrichosis (slightly darker chest/back hair, fuller beard, higher cheek/temple hairs), but was otherwise tolerated. 

Case Summary #7: Male (28), 2–3 Months on Oral Finasteride 1 mg Monotherapy

This 28-year-old male’s intervention included oral finasteride 1 mg daily, weekly microneedling with dermastamp 1.0–1.5 mm, and supplementation with vitamin D3 + K2, zinc, folate, magnesium glycinate, and ketoconazole 2% shampoo. Additionally, he made lifestyle adjustments, including going to the gym 2x/week and starting a higher-protein diet.

He noted a mild shedding phase in the first month of treatment. By month 2, he described the first visible tiny regrowth after a buzz cut, by which point the shedding had reduced. Overall, the patient described early regrowth at the hairline and thinning zones. He reported no side effects on finasteride 1 mg daily, stating that libido and energy have remained unchanged or improved.

Case Summary #8: Male (unspecified age), 3 Years on Oral Finasteride 1 mg Daily + Topical Minoxidil

This male Redditor’s intervention over 3 years was oral finasteride 1 mg daily and topical minoxidil (strength not specified).

In the first year, he noted steady cosmetic improvement, followed by continued thickening and maintenance of gains over years 2-3. Overall, the user reported substantial density gain, with perceived improvement in the hairline and temples over time. He mentioned no significant side effects and confirmed his sex drive had remained unchanged throughout treatment. He noted that the minoxidil sometimes caused dandruff and that on finasteride, he required greater mental focus to push weight-lifting sets to failure. 

Case Summary #9: Male (early 30s), 3.5 Months on Oral Finasteride 1.25 mg Daily

This male, in his early 30s, opted for a treatment consisting of oral finasteride monotherapy at 1.25 mg daily (5 mg tablets quartered). He described a mild daily shedding phase within the first month of treatment. By month 2.5, he reported his first visible thickening. At the 3.5-month progress report, the user achieved a fuller crown with reduced scalp show-through. He reported no side effects. 

Case Summary #10: Male (25), 5.5 Months on Oral Finasteride 1.25 mg Daily + Oral Minoxidil 5 mg Daily

This 25-year-old South Asian male’s intervention was oral finasteride 1.25 mg daily (5 mg tablets quartered) and oral minoxidil, starting at 2.5 mg daily, titrated to 5 mg after 3 months. He described a substantial shedding phase, particularly in the first 3 weeks of month 3. The following month, he reported progressive thickening and density gains with improved coverage. As of month 5.5, he is still improving and continuing both agents unchanged. Overall, he reported a marked increase in density, with a thicker texture, and the crown and hairline both looked fuller than baseline. He reported no side effects on either dose level for finasteride or oral minoxidil. 

Probable Regrowth Timeline

Based on the available research (which you can take a look at with our research tables here), we have created a probable hair regrowth timeline.

Months 0-3: Adjustment Phase

In the first three months, most users experience minimal visible change. Finasteride actively lowers scalp and serum DHT levels, initiating follicle recovery. Some users notice a temporary increase in shedding as older hairs are shed to make way for new growth, while others observe subtle stabilization of hair loss.

Months 3-6: Reduction in Shedding

By this stage, a clear reduction in hair shedding often becomes noticeable. Although visible thickening remains limited for many, the treatment is beginning to normalize hair cycling. Early responders may report small areas of improved density, particularly in the crown or vertex.

Months 6-12: Early Cosmetic Improvements

Between 6 and 12 months, most responders start to see visible regrowth. Hair density gradually improves, strands appear thicker, and areas of thinning begin to fill in. The crown region typically shows improvement sooner than the frontal hairline, which tends to respond more slowly. Continued adherence is essential during this phase to sustain progress.

Months 12-24: Peak Response Period

During the second year, responders generally achieve their maximum results. Hair density, coverage, and stabilization reach their highest levels, with further visible gains possible in some individuals. Those starting with more advanced thinning usually experience consolidation rather than full growth.

Months 24+: Maintenance and Long-Term Stability

After two years, most users reach a plateau in visible improvement. Continued daily use of finasteride is needed to preserve these gains, as stopping the medication often results in gradual hair loss returning to baseline within 6-12 months. Some people combine treatments at this point to achieve further outcomes.

For most users, oral finasteride provides progressive, steady improvements over time, with long-term commitment being the key to maintaining results.

Setting Realistic Expectations

It’s important to set realistic expectations when starting any treatment. Finasteride primarily stabilizes hair loss during the early months, with noticeable growth typically developing later in the treatment course. True cosmetic improvement usually unfolds gradually over 12 to 24 months rather than weeks, reflecting the natural pace of the hair growth cycle. 

Clinical trials suggest that most men experience visible thickening and halting of progression rather than full restoration, effectively “turning back the clock” by two to five years in terms of density and coverage.^[11]Kaufman, K.D., Olson, E.A., Whiting, D., Savin, R., DeVillez, R., Bergfeld, W., Price, V.H., Van Neste, D., Roberts, J.L., Hordinsky, M., Shapiro, J., Binkowitz, B., Gormley, G.J. (1998). Finasteride … Continue reading,^[12]Price, V.H., Roberts, J.L., Hordinsky, M., Olsen, E.A., Savin, R., Bergfeld, W., Fiedler, V., Lucky, A., Whiting, D.A., Pappas, F., Culbertson, J., Kotey, P., Meehan, A., Waldstreicher, J. (2000). … Continue reading,^[13]Rossi, A., Mari, E., Scarno, M., Garelli, V., Maxia, C., Scali, E., Iorio, A., Carlesimo, M. (2012). Comparative effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a … Continue reading 

Consistent photographic tracking using identical lighting and angles can help visualize these incremental gains. Long-term adherence is crucial, as discontinuation typically leads to renewed miniaturization and hair loss within several months of stopping treatment.

Practical Takeaways

• Oral finasteride remains the most effective DHT blocker for male AGA
• Decades of clinical data make results highly predictable and durable
• The safety profile is well-established, with sexual side effects uncommon and often reversible
• Combining treatments can improve outcomes, especially for advanced loss.

Final Thoughts

Oral finasteride remains the most extensively studied and clinically validated treatment for androgenic alopecia, offering predictable outcomes for most users through gradual thickening, stabilization of shedding, and preservation of existing hair rather than dramatic restoration. While newer options like oral minoxidil are gaining popularity, they remain off-label despite growing supportive evidence and should be used under medical supervision. 

The key to achieving and maintaining meaningful results lies in consistency, patience, and realistic expectations, recognizing that hair regrowth is a slow, cumulative process measured over months and years. By grounding expectations in clinical evidence rather than anecdotal extremes, patients can make informed, balanced decisions and stay committed to a long-term plan that maximizes both safety and effectiveness.

Oral finasteride has established itself as a highly effective treatment for androgenic alopecia (AGA) and is widely prescribed around the globe. Its success can be largely attributed to its proven ability to slow hair loss and stimulate regrowth by inhibiting the conversion of testosterone to DHT, the hormone chiefly responsible for follicular miniaturization. 

However, despite its well-documented efficacy, oral finasteride has become equally notorious for its potentially systemic side effects. Some men experience adverse effects such as decreased libido, erectile dysfunction, mood changes, and even persistent symptoms after discontinuation, a phenomenon called post-finasteride syndrome.^[1]Diviccaro, S., Melcangi, R.C., Giatti, S. (2019). Post-finasteride syndrome: an emerging clinical problem. Neurobiology of Stress. 12. 100209. Available at: https://doi.org/10.1016/j.ynstr.2019.100209 This reputation has prompted many to seek alternatives that are both effective and safer for long-term use.

Recently, topical finasteride formulations have garnered attention as a promising alternative. By delivering the medication directly to the scalp, topical finasteride aims to minimize systemic absorption and thereby reduce the likelihood of side effects while still providing the benefits of DHT inhibition where it matters most. This alternative approach has piqued the interest of both patients wary of systemic issues and clinicians seeking tailored treatments.

In this article, we will examine whether topical finasteride can serve as a viable alternative to its oral counterpart. The main focus will be on answering three questions:

1. Can topical finasteride effectively regrow hair in those affected by AGA?
2. Does it match the efficacy results seen with oral finasteride?
3. Can it reduce hair loss while offering a more favorable side effect profile?

Ulo offers finasteride options that range from low to high dose finasteride – allowing you to be flexible in your treatment choices.

Interested in Topical Finasteride?

Low-dose & full-strength finasteride available, if prescribed*

Take the next step in your hair regrowth journey. Get started today with a provider who can prescribe a topical solution tailored for you.

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*Only available in the U.S. Prescriptions not guaranteed. Restrictions apply. Off-label products are not endorsed by the FDA.

Oral vs. Topical Finasteride

Some research directly compares oral finasteride (1 mg daily) with various concentrations of topical finasteride, aiming to match hair regrowth efficacy while minimizing systemic side effects. Let’s take a look at a couple of examples:

Study 1 – Piraccini et al., 2022 (Phase III RCT, 24 weeks)

• Compared topical finasteride (0.25% spray) to oral finasteride (1 mg/day) and placebo in men with AGA.^[2]Piraccini, B.M., Blume-Peytavi, U., Scarci, F., Jansat, J.M., Falques, M., Otero, R., Tamarit, M.L., Galvan, J., Tebbs, V., Massana, E., Topical Finasteride Study Group. Efficacy and safety of … Continue reading
• The increase in hair count on a defined scalp area was similar for topical and oral finasteride, both outperforming the placebo, suggesting comparable clinical benefit.
• Systemic finasteride (oral) reduced mean serum DHT by 55.6%,  whereas topical finasteride reduced it by 34.5%. Plasma finasteride exposure from topical application was over 100 times lower than from oral administration. 
• Both had similar low rates of mild side effects, but sexual side effects, but sexual side effects were more associated with oral treatment. 
• Caveats: The “target area” measured may not represent the full scalp effects; although systemic absorption, albeit at a much lower level with topical application, still occurred and varied by formulation. 

Study 2 – Bhura, 2013 (RCT, 8 months)

• Parallel-group comparison in male AGA, tracking hair density and systemic DHT.^[3]Bhura, M. (2013). Comparative Analysis of Topical and Oral Finasteride in Androgenetic Alopecia: Impact on Hair Growth, Systemic Absorption, and Adverse Effects. Indian Journal of Basic and Applied … Continue reading 
• Oral finasteride resulted in slightly superior increases in hair number and thickness, although the difference was not statistically significant.
• Oral finasteride significantly reduced systemic DHT and caused more sexual side effects; topical finasteride led to minimal serum DHT changes and almost no systemic side effects, with most reactions being local (e.g., irritation).
• Those worried about long-term systemic effects preferred topical use, despite slightly less pronounced gains.

Study 3 – Hajheydari, 2009 (RCT, 6 months)

• Compared a 1% topical gel + placebo tablet with oral finasteride 1 mg/day + placebo gel.^[4]Hajheydari, Z., Akbari, J., Saeedi, M., Shokoohi, L. (2009). Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Indian Journal of Dermatology, … Continue reading 
• Both the gel and tablet produced statistically significant increases in total hair count and terminal hair count.
• There were no significant differences in hair thickness, hair count, or size of the bald area between the two groups. 

Mechanism of Action

Finasteride Pharmacodynamics

Finasteride is a competitive inhibitor of 5α-reductase, primarily targeting the type II isoenzyme at therapeutic doses, which predominates in the hair follicles and prostate. As mentioned above, this enzyme catalyzes the conversion of testosterone to DHT. 

At higher tissue concentrations, finasteride can also inhibit type I 5α-reductase, which is primarily found in the skin and sebaceous glands; however, its clinical significance for hair loss at standard doses is limited. By selectively inhibiting the type II enzyme, finasteride effectively lowers local and systemic DHT levels.^[5]Finn, D.A., Beadles-Bohling, A., Beckley, E.H., Ford, M.M., Gililland, K.R., Gorin-Meyer, R.E., Wiren, K.M. (2006). 12(1). 53-76. A New Look at the 5α-reductase Inhibitor Finasteride. CNS Drug … Continue reading 

What is Finasteride’s Effect on DHT Suppression?

Finasteride’s effect on DHT suppression is characterized by a logarithmic dose-response curve, meaning that even very low systemic levels can produce a marked reduction in both serum and scalp DHT. Most of the drug’s inhibitory action is achieved at low doses, with additional dosing yielding only marginal further effect.

As a result, even minimal “leakage” of topically applied finasteride into the bloodstream can decrease DHT levels elsewhere in the body.

Pharmacokinetic studies show that inhibition of type-II 5ɑ-reductase reaches saturation at typical clinical dosage, while type-1 enzyme inhibition requires much higher concentrations. This nonlinear pharmacodynamic profile explains both the strong efficacy and the wide safety margin of topical finasteride: a small amount achieves most of the desired effect, so careful formulation is crucial to maximize scalp delivery while minimizing unwanted systemic exposure.^[6]Suzuki, R., Satoh, H., Ohtani, H., Hori, S., Sawada, Y. (2010). Saturable Binding of Finasteride to Steroid 5ɑ-reductase as Determinant of Nonlinear Pharmacokinetics. Drug Metabolism and … Continue reading 

What the Science Says

Topical finasteride has been studied across a 200-fold concentration range, from 0.005% solutions to 1% gels. Collectively, these trials demonstrate meaningful reductions in shedding and measurable regrowth; however, systemic exposure increases with dose and vehicle potency.

Study	Concentration & Vehicle	Hair Growth-Outcomes	Systemic/Serum Findings
Mazzarella 1997, single-blind, 52 men/women, 16 months.	0.005% hydro-alcoholic solution	73% reported “high effectiveness”; wash-test hair counts improved; slowed shedding by month 6	No significant change in plasma DHT or testosterone; absorption was negligible.
Tanglertsampan 2012 RCT, 33 men, 24 weeks.	0.1% lotion + 3% minoxidil	The combination arm gained more hairs/cm2 and thicker shafts than minoxidil alone.	Local irritation mild; systemic parameters not monitored.
Datta 2021 double-blind trial, 35 participants completed, 6 months.	0.1% lotion +5% minoxidil vs oral 1 mg.	The topical combination was non-inferior to oral minoxidil for reducing the Hamilton-Norwood stage.	Sexual adverse events only occurred in the oral group; topical was well-tolerated.
Caserini 2016 OK study, 50 men, 1 week; Piraccini 2022 phase III, 323 completers, 24 weeks.	0.25% solution.	-70% scalp DHT after once-daily 1 mL; +20.2 hairs in 1 cm2 target area at 24 weeks – numerically equal to oral 1 mg.	100-200 μL doses reduced serum DHT by only 24-26%; 400 μL treatment reduced levels by 44-48%; Cmax was more than 100 times lower than oral.
Rossi 2020 retrospective, 69 women, 12-18 months.	0.5% lotion (postmenopausal women)	The Finasteride + minoxidil group scored higher on a 7-point global scale compared to the 17ɑ-estradiol + minoxidil group.	No androgenic side effects reported.
Hajheydari 2009 DB-RCT, 45 men, 6 months.	1% gel	Increases in total and terminal hair counts matched those of oral 1 mg; the bald area remained unchanged.	Serum DHT not assayed; clinical side-effects minimal.

Low-Dose Takeaways

Even a micro-dose of 0.005% twice daily (~0.1 mg/day) curbed shedding and improved density without measurable systemic suppression, making it an attractive option for highly risk-averse users.^[7]Mazzarella, F., Loconsole, F., Cammisa, A., Mastrolonardo, M., Vena, G.A. (1997). Topical finasteride in the treatment of androgenic alopecia. Preliminary evaluations after a 16-month therapy course. … Continue reading

Mid-Range (0.1-0.25%)

Adding 0.1% finasteride to minoxidil amplifies regrowth compared to minoxidil alone, while standalone 0.25% sprays deliver oral-level scalp DHT blockade, maintaining serum exposure roughly one-tenth that of tablets. Dose and volume are critical.^[8]Caserini, M., Radicioni, M., Leuratti, C., Terragni, E., Iorizzo, M., Palmieri, R. (2016). Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men … Continue reading

High-Dose (0.5-1%)

Topical finasteride options at 0.5% have been shown to extend benefits to female pattern hair loss with good tolerability.^[9]Rossi, A., Magri, F., D’Arino, A., Pigliacelli, F., Muscianese, M., Leoncini, P., Caro, G., Federico, A., Fortuna, M.C., Carlesimo, M. (2020). Efficacy of Topical Finasteride 0.5% vs 17ɑ-Estradiol … Continue reading

Why Formulation and Dose Matter

1. The vehicle drives absorption: according to the studies, hydro-alcoholic sprays penetrate faster than gels or liposomes, explaining divergent serum DHT curves at equal nominal strengths. 
2. Daily drug load, not percentage alone, predicts systemic spill over; 0.025% at 400 μL approaches the systemic impact of oral dosing, whereas 100 μL does not.
3. Combination therapy often allows for a lower finasteride concentration to achieve equal cosmetic benefits, thereby minimizing exposure.

Minimizing Systemic Absorption

While topical finasteride offers an option for minimizing systemic exposure, several key variables influence the amount that enters the bloodstream, and this can occur surprisingly quickly.

Key Factors Affecting Systemic Absorption

• Carrier Agent: The vehicle used to deliver finasteride dramatically alters absorption. Alcohol-based (ethosomal) carriers enhance drug penetration through the skin and into deeper layers like the dermis much more than conventional liposomes, which tend to remain more superficial. One study found that ethosomes resulted in approximately six times greater dermal accumulation than liposomes, highlighting the direct impact of carrier choice on systemic exposure.^[10]Rao, Y., Zheng, F., Zhang, X., Gao, J., Liang, W. (2008). In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers. AAPS PharmSciTech. 9(3). 860-865. … Continue reading
• Time on Scalp Before Washing: The longer finasteride remains on the scalp before washing, the greater the chance for absorption through the skin. Washing off too soon reduces drug uptake, but leaving it for extended periods increases both local efficacy and systemic exposure. Guidelines often recommend allowing at least 4-6 hours on the scalp, though this can vary by formulation. 
• Frequency of Use: If you can keep topical finasteride on your scalp for at least 10-12 hours, once-daily applications of low-dose topical finasteride might be beneficial. For those who can only tolerate finasteride for 4-6 hours, twice-daily applications may be better. You can read more about how often topical finasteride should be applied here.
• Individual Skin Permeability: Personal factors, including skin thickness, barrier integrity, genetics, and even scalp conditions, can strongly influence how much finasteride penetrates the scalp. Individuals with more permeable skin may absorb a greater amount of the drug systemically, increasing the risk of side effects.^[11]Brito, S., Baek, M., Bin, B-H. (2024). Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery. Pharmaceutics. 16(11). 1403. Available at: … Continue reading 

How To Maximize Gains and Minimize Risk

To achieve the best results and reduce the likelihood of side effects, there are several strategies you can employ:

• Establish a Baseline with Serum DHT Testing

Before starting topical finasteride, get a baseline measurement of your serum DHT levels through a blood test. This serves as a reference to assess the extent to which systemic DHT is affected by your treatment. 

• Retest After 30 Days

After one month of consistent topical use, repeat the serum DHT test under the same conditions (preferably in the morning, fasted, and at a similar time of day). This helps you gauge systemic absorption and adjust your regimen if your serum DHT levels drop excessively. Hormone levels fluctuate based on daily rhythms, food intake, and stress, so always test under similar circumstances: morning, fasted, and ideally before applying the day’s finasteride.

• Avoid Confounding Supplements

Avoid supplements that may directly affect DHT, such as those that increase DHT (e.g., creatine) or quercetin (which may lower it). This ensures your test results and progress are a direct reflection of the topical finasteride.^[12]van der Merwe, J., Brooke, N.E., Myburgh, K.H. (2009). Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. Clinical … Continue reading,^[13]Ma, Z., Nguyen, T.H., Huynh, T.H., Do, P.T., Huynh, H. (2004). Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation. Journal of … Continue reading 

• Be Patient – It Takes Time

Visible improvements often require 12-24 months. Don’t make hasty adjustments if you don’t see immediate changes; hair cycles are slow. 

• Track Your Progress Objectively

Use standardized, high-quality photo documentation, same angle, lighting, and distance each time, to objectively monitor changes in hair density and coverage.

Combination Therapies

Robust evidence supports the use of combination therapies for AGA, with multi-modal approaches consistently outperforming monotherapy in terms of efficacy and speed of regrowth.

Finasteride + Minoxidil: Studies show that pairing topical finasteride with 5% minoxidil yields superior hair density and patient satisfaction compared to either agent alone, particularly after 24 weeks of treatment.^[14]Apoorva, V.B., Vibhu, M., Singh, R.H., Smita, T. (2023). Comparative Efficacy of Topical Finasteride (0.25%) in Combination with Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male … Continue reading,^[15]Rossi, A., Caro, G. (2023). Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: A prospective, randomized, … Continue reading,^[16]Abeck, F., Hansen, I., Kott, J., Schroder, F., Garrahy, E., Veneroso, J., Runger, A., Torster, L., Schneider, S.W., von Buren, J. (2024). Patient-reported outcomes of topical finasteride/minoxidil … Continue reading This combination is effective for both new users and those who have experienced shedding after discontinuing oral finasteride.

Finasteride + Microneedling: Adding microneedling to topical therapy can significantly enhance outcomes. Clinical trials demonstrated that combining microneedling with minoxidil and/or finasteride increased hair density and shaft diameter more than minoxidil alone, with effects noticeable within just 12 weeks.^[18]Chang, Y., Zhang, W., Zhou, J., Lv, L., He, Q., Chen, Y., Wang, P., Zhai, Q. (2025). Clinical efficacy of microneedle combined with 5% Minoxidil solution and finasteride in the treatment of … Continue reading,^[19]Adistri, K., Sirait, S.P., Rihatmadja, R., Legiawati, L., Indriatmi, W., Saldi, S.R.F. (2024). Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic … Continue reading 

Triple Topical Therapy: Preliminary studies on formulations that combine finasteride, dutasteride, and minoxidil show promising results, with visible regrowth as early as three months in some cases.^[20]Rafi, A.W., Katz, R.M. (2011). Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA. ISRN Dermatology. 241953. Available at: … Continue reading

So, combination therapy appears to be more effective than monotherapy. Therefore, leveraging two or more topical therapies or adding microneedling can support hair regrowth outcomes.

Who Should (or Shouldn’t) Use Topical Finasteride?

Good Candidates:

• Men diagnosed with AGA.
• Those who tolerate oral finasteride but seek to minimize systemic risks.

Not Ideal For: 

• People with hair loss from causes other than AGA (e.g., alopecia areata, telogen effluvium). 
• Those who have previously shown a poor response to finasteride.
• Anyone trying to conceive, or with infants, toddlers, or pregnant individuals in close contact.
• Users who are unable or unwilling to follow consistent application routines or medical monitoring. 

Final Verdict

Topical finasteride is a legitimate option for hair regrowth. When formulated and used properly, it can rival oral finasteride’s effectiveness with a lower risk of systemic side effects. Success hinges on the right delivery method, correct dilution, and consistent application. While not flawless, it excels as part of a comprehensive regimen, especially when paired with therapies like minoxidil or microneedling. 

For those hesitant about oral medication, topical finasteride offers a practical, lower-risk compromise, provided users carefully follow evidence-based protocols to optimize both safety and results. Used strategically, it is a potent addition to hair loss treatment plans.

Topical minoxidil is a first-line treatment for female pattern hair loss (FPHL) and other conditions such as telogen effluvium and traction alopecia. Many women of reproductive age use minoxidil and may wonder about its safety when trying to conceive or in early pregnancy.

While most reproductive safety discussions focus on oral or systemic medications, even topically applied drugs can raise questions about potential effects on fertility or early fetal development. Although systemic absorption from topical formulations is low, uncertainty persists regarding potential hormonal or embryonic effects.

This article examines available evidence to evaluate whether topical minoxidil poses any risk to female fertility or conception. By reviewing preclinical studies and clinical and pharmacological data, we aim to clarify whether there is any risk associated with topical minoxidil when trying to conceive.

Topical Minoxidil: Mechanism and Pharmacology

Minoxidil may promote hair growth through several complementary mechanisms. After topical application, the drug is enzymatically converted by sulfotransferase (SULT1A1) into minoxidil sulfate, its active form. This metabolite enhances potassium channel activity within follicular cells, promoting cell proliferation and prolonging the anagen (growth) phase of the hair cycle. Additionally, minoxidil increases vascularity around the follicle by stimulating vascular endothelial growth factor (VEGF), improving oxygen and nutrient delivery to support stronger, thicker hair growth.^[1]Suchonwanit, P., Thammarucha, S., & Leerunyakul, K. (2019). Minoxidil and its use in hair disorders: a review. Drug Design, Development and Therapy. 13. 2777-2786. Available at: … Continue reading

There are important pharmacological distinctions between topical and oral formulations. Topical minoxidil acts locally on the scalp with minimal systemic absorption, which significantly reduces the risk of adverse effects. In contrast, oral minoxidil can cause systemic side effects, such as fluid retention, weight gain, increased blood pressure (hypertension), and other cardiovascular changes.^[2]StatPearls Editorial Team. (no date). Minoxidil. In: StatPearls [Internet]. StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK482378/ (Accessed: October 2025)

Female Fertility: What Matters When Trying to Conceive?

Female fertility relies on coordinated hormonal cycles, healthy egg development, and a receptive uterine environment. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) regulate ovulation, while estrogen and progesterone prepare the uterus for implantation and support early pregnancy.^[3]Thiyagarajan, D. K., Basit, H., & Jeanmonod, R. (2024 Jan 1). Physiology, menstrual cycle. In: StatPearls [Internet]. StatPearls Publishing. Available at: … Continue reading In addition to hormonal balance, healthy reproductive anatomy is important: clear fallopian tubes, a healthy uterus, and a cervix free of significant abnormalities are required for fertilization and embryo implantation.^[4]Mayo Clinic Staff. (no date). Female infertility – Symptoms & causes. Available at: https://www.mayoclinic.org/diseases-conditions/female-infertility/symptoms-causes/syc-20354308/ (Accessed: … Continue reading

Of course, women, or individuals who are female at birth, looking to conceive also need to consider the impact of medications following conception. The safe use of medications is essential to support maternal health and healthy fetal development while minimizing risks of complications and birth defects (teratogenic effects).

Systemic medications can interfere with fertility and pregnancy by disrupting hormonal balance or exerting teratogenic effects. For example, antiandrogens such as spironolactone, cyproterone acetate, and finasteride, sometimes prescribed for female hair loss, are contraindicated when trying to conceive due to their potential impact on fetal development.^[5]BinJadeed, H. F., & Alajlan, A. (2021). Pregnancy and neonatal outcome with maternal exposure to finasteride: a case series. Journal of Dermatology and Dermatologic Surgery. 25(2). 84-86. … Continue reading,^[6]Wu, M., Yu, Q., & Li, Q. (2016). Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget. 7(50). 82074-82084. … Continue reading Animal models suggest these agents interfere with androgen signaling, which is essential for normal sexual differentiation, particularly in male fetuses.^[7]Conley, J. M., Lambright, C. S., Evans, N., Cardon, M., Furr, J., Wilson, V. S., & Gray Jr, L. E. (2018). Mixed “antiandrogenic” chemicals at low individual doses produce reproductive tract … Continue reading In contrast, nutritional supplements like iron, vitamin D, and biotin are generally safe and can support overall reproductive health.

Systemic Absorption of Topical Minoxidil: How Much Gets In?

Topical minoxidil is formulated to act locally on the scalp, with only a small proportion entering systemic circulation – typically around 1–2%.^[8]Suchonwanit, P., Thammarucha, S., & Leerunyakul, K. (2019). Minoxidil and its use in hair disorders: a review. Drug Design, Development and Therapy. 13. 2777-2786. Available at: … Continue reading Pharmacokinetic studies show that this absorption rate can vary depending on several factors, including formulation strength (2% vs. 5%), frequency of application, and the integrity of the scalp barrier. Plasma minoxidil levels in individuals using topical formulations generally remain well below those associated with systemic pharmacologic or reproductive effects observed in animal studies.^[9]Singh, S., Patil, A., Kianfar, N., Waśkiel-Burnat, A., Rudnicka, L., Sinclair, R., & Goldust, M. (2022). Does topical minoxidil at concentrations higher than 5% provide additional clinical … Continue reading,^[10]Hsu, C. L., Liu, J. S., Lin, A. C., Yang, C. H., Chung, W. H., & Wu, W. G. (2014). Minoxidil may suppress androgen receptor‐related functions. Oncotarget. 5(8). 2187-2197. Available at: … Continue reading

By contrast, oral minoxidil is almost completely absorbed, leading to significantly higher plasma concentrations and systemic exposure. This explains why oral therapy, though often more potent, also carries a greater risk of systemic side effects, including edema, tachycardia, and generalized hypertrichosis.^[11]Randolph, M., & Tosti, A. (2021). Oral minoxidil treatment for hair loss: a review of efficacy and safety. Journal of the American Academy of Dermatology. 84(3). 737-746. Available at: … Continue reading

Does Topical Minoxidil Affect Female Fertility, Conception, or Pregnancy?

When considering the impact of medications on women’s fertility and ability to conceive, it is also essential to review the evidence regarding potential effects during pregnancy, as treatments will inevitably continue to be taken into early pregnancy, and systemic effects may be long-lasting. Here, we review preclinical and clinical evidence on whether topical minoxidil affects female fertility and pregnancy.

Preclinical Evidence

Minoxidil is classified as a non-hormonal treatment, suggesting it is unlikely to impact hormonal cycles that impact fertility. However, due to the relationship between hair growth and hormonal pathways, some preclinical research has focused on how minoxidil affects androgen pathways.

One cell-based study suggests that minoxidil can directly interact with and weaken androgen receptor signaling. However, this study used higher concentrations of minoxidil than would be used in hair loss treatment, and for practical purposes, topical minoxidil remains classified as a non-hormonal treatment.^[12]Hsu, C. L., Liu, J. S., Lin, A. C., Yang, C. H., Chung, W. H., & Wu, W. G. (2014). Minoxidil may suppress androgen receptor‐related functions. Oncotarget. 5(8). 2187-2197. Available at: … Continue reading

However, in an animal model using golden Syrian hamsters, 5% topical minoxidil did not prevent the androgen-dependent growth of pigmented spots, suggesting that minoxidil does not have any effect on androgen response.^[13]Nuck, B. A., Fogelson, S. L., & Lucky, A. W. (1987). Topical minoxidil does not act as an antiandrogen in the flank organ of the golden Syrian hamster. Archives of Dermatology. 123(1). 59-61. … Continue reading 

There is a significant lack of research using preclinical animal models investigating the impact of topical minoxidil on female fertility and during pregnancy. However, one small-scale study did examine the effect of 5% topical minoxidil on embryonic mortality in rats. They found no impact of daily minoxidil application over the course of 20 days of pregnancy compared to the control group. However, the sample size was relatively small (20 rats in total), and no molecular or cellular analysis was performed to look for potential mechanisms that could cause embryonic lethality.^[14]Turkina, V. A., Chemodurova, N. Y., Pryzyglei, H. V., & Kuzminov, Y. B. (2021). Potential embryotoxic effect study of minoxidil-containing lotion in experiment with female rats. Світ … Continue reading

Clinical Evidence

Unfortunately, a lack of research into the impact of medications on women and fetuses during pregnancy is a systemic issue within medicine. Pregnant women are generally excluded from clinical trials due to safety concerns, as well as the confounding impact of widespread hormonal changes associated with pregnancy.^[15]Stock, S. J., & Norman, J. E. (2019). Medicines in pregnancy. F1000Research. 8(F1000Faculty Rev):911. Available at: https://doi.org/10.12688/f1000research.17535.1 These issues extend to women trying to conceive, and most clinical trials have explicit protocols that remove individuals from clinical trials after they become pregnant.^[16]Phelan, A. L., Kunselman, A. R., Chuang, C. H., Raja-Khan, N. T., & Legro, R. S. (2016). Exclusion of women of childbearing potential in clinical trials of type 2 diabetes medications: a review … Continue reading

The safety of medications for pregnant women and their children is typically established after drugs have come to market, through observational studies and pharmacovigilance, which looks for cases where problems have arisen. While such processes are good at spotting signals of high risk, these forms of evidence are less powerful than clinical trials and cannot detect less impactful effects.

As such, determining the safety of drugs for pregnant women is often done using scarce information. As a result, many medications are contraindicated (their use is advised against) for pregnant women due to a lack of evidence, not because of evidence.^[17]Thomas, S. H., & Yates, L. M. (2012). Prescribing without evidence – pregnancy. British Journal of Clinical Pharmacology. 74(4). 691-697. Available at: … Continue reading  

Multiple reviews of the safety of dermatological treatments in pregnant women advise against the use of monoxidil.^[18]Koh, Y. P., Tian, E. A., & Oon, H. H. (2019). New changes in pregnancy and lactation labelling: Review of dermatologic drugs. International Journal of Women’s Dermatology. 5(4). 216-226. … Continue reading,^[19]Truong, T. M., Yaghi, M., & Murase, J. (2023). Dermatologic Drug Safety in Pregnancy. Journal of Dermatology for Physician Assistants. 17(3). 1-12. Available at: … Continue reading,^[20]Suchonwanit, P., Thammarucha, S., & Leerunyakul, K. (2019). Minoxidil and its use in hair disorders: a review. Drug Design, Development and Therapy. 13. 2777–2786. Available at: … Continue reading However, this advice appears to be based on two case studies where topical minoxidil was theorized as the cause of the birth defects. Case studies present a single individual (or group of individuals) where an event or phenomenon has occurred. They are a weak form of evidence and are typically used as the basis for larger studies. 

In one of these case studies, the pregnancy of a 28-year-old woman who was applying topical minoxidil was terminated due to the presence of fetal malformation. Topical minoxidil was suggested as a possible cause of teratogenesis.^[21]Smorlesi, C., Caldarella, A., Caramelli, L., Di Lollo, S., & Moroni, F. (2003). Topically applied minoxidil may cause fetal malformation: a case report. Birth Defects Research Part A: Clinical … Continue reading The other study noted a case of a rare condition called caudal regression syndrome in a fetus where the mother had been using topical minoxidil, though other causes were also proposed.^[22]Rojansky, N., Fasouliotis, S. J., Ariel, I., & Nadjari, M. (2002). Extreme caudal agenesis. Possible drug-related etiology?. Journal of the American Academy of Dermatology. 47(3). 241-245. … Continue reading These cases were published in 2002 and 2003, and both advised that further studies were warranted.

In a more systematic approach, one study analysed FDA Adverse Event Reporting System (FAERS) data, which collects evidence of adverse effects related to medications.^[23]Wu, M., Yu, Q., & Li, Q. (2016). Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget. 7(50). 82074-82084. … Continue reading The study used data collected between 2004 and 2014. Over the ten years analyzed, 2 cases of induced abortion and 2 cases of spontaneous abortion were reported in women using minoxidil. This represents around 2% of cases reported. For comparison, induced abortion represented around 18% of reported adverse effects related to finasteride, for which it was the most commonly reported issue. No cases related to sexual dysfunction or loss of libido were reported.

It is due to the lack of evidence and the potential issues that these case studies raise that minoxidil is typically contraindicated for women who are trying to conceive or are pregnant. There is no evidence to suggest that minoxidil has any impact on female fertility. Larger observational and controlled studies would be required to make evidence-based conclusions regarding the safety of minoxidil for women trying to conceive.

Summary Consensus

There is no direct evidence linking topical minoxidil to reduced fertility. The use of topical minoxidil is advised against for women trying to conceive due to a small number of reported cases where topical minoxidil was associated with fetal abnormalities. 

Counseling and Clinical Recommendations

The Food and Drug Administration (FDA) classifies topical minoxidil as a pregnancy category C drug. This means studies have shown a risk to the fetus, but there are no adequate, controlled studies in pregnant women. Such drugs are generally only prescribed if there is a significant benefit to the mother that outweighs potential risks. As such, a review published by the American Academy of Dermatology in 2025 advises against using minoxidil while pregnant.^[25]Olsen, E. A., Sinclair, R., Hordinsky, M., Mesinkovska, N. A., Sadick, N., Shapiro, J., & Bergfeld, W. (2025). Summation and recommendations for the safe and effective use of topical and oral … Continue reading In the UK, the National Institute for Health and Care Excellence (NICE) also advises against the use of topical minoxidil when pregnant or breastfeeding.^[26]National Institute for Health and Care Excellence. (no date). Female-pattern hair loss (female androgenetic alopecia) — Prescribing information: Topical minoxidil. Available at: … Continue reading

Does topical minoxidil cause infertility?

There is no evidence to suggest that topical minoxidil can impact fertility in women. There are a very limited number of cases reported where minoxidil has been associated with impotence in men.^[27]Rietschel, R. L., & Duncan, S. H. (1987). Safety and efficacy of topical minoxidil in the management of androgenetic alopecia. Journal of the American Academy of Dermatology. 16(3). 677-685. … Continue reading

Does minoxidil interfere with female hormones or ovulation?

There is limited research into the effect of minoxidil on female hormones or ovulation. However, minoxidil is not a hormonal drug, and there is limited evidence to suggest that it interferes significantly with hormones at levels associated with topical treatment.

Should women stop minoxidil months before trying to conceive?

While there is no evidence that minoxidil can impact women’s ability to conceive, it is not advised to use the treatment while pregnant. Therefore, it is recommended to stop using minoxidil while trying to conceive.^[28]Olsen, E. A., Sinclair, R., Hordinsky, M., Mesinkovska, N. A., Sadick, N., Shapiro, J., & Bergfeld, W. (2025). Summation and recommendations for the safe and effective use of topical and oral … Continue reading

Can minoxidil exposure cause miscarriage or birth defects?

There are limited case reports that associate topical minoxidil with birth defects and fetal malformation, leading to termination. These findings have not been expanded on by larger trials or observational studies.^[29]Smorlesi, C., Caldarella, A., Caramelli, L., Di Lollo, S., & Moroni, F. (2003). Topically applied minoxidil may cause fetal malformation: a case report. Birth Defects Research Part A: Clinical … Continue reading,^[30]Rojansky, N., Fasouliotis, S. J., Ariel, I., & Nadjari, M. (2002). Extreme caudal agenesis. Possible drug-related etiology?. Journal of the American Academy of Dermatology. 47(3). 241-245. … Continue reading

Do all hair loss drugs have the same reproductive risks?

Different hair loss treatments have fundamentally different mechanisms. Finasteride and dutasteride are hormonally active and may impact male fertility and fetal development.^[31]BinJadeed, H. F., & Alajlan, A. (2021). Pregnancy and neonatal outcome with maternal exposure to finasteride: a case series. Journal of Dermatology and Dermatologic Surgery. 25(2). 84-86. … Continue reading,^[32]Wu, M., Yu, Q., & Li, Q. (2016). Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget. 7(50). 82074-82084. … Continue reading Risks associated with minoxidil are significantly less well established, and adverse reproductive events have been shown to be significantly lower than finasteride.^[33]Wu, M., Yu, Q., & Li, Q. (2016). Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget. 7(50). 82074-82084. … Continue reading

Latest Research and Knowledge Gaps

There is a significant gap in our knowledge of whether minoxidil affects pregnancy and the mechanisms by which it might do so. Data from preclinical models has focused on hair cycle dynamics rather than reproductive parameters, with only limited research on its impact on androgenic hormonal pathways.

Both of the case studies that associated topical minoxidil with adverse pregnancy outcomes are over 20 years old, with no follow-up studies to better understand these reports. Clinical trials or observational studies would be necessary to make evidence-based assessments on the safety of minoxidil during pregnancy and its impact on female fertility.

Final Thoughts

Current evidence does not show that topical minoxidil impairs fertility or conception. However, because pregnancy safety data remain incomplete, discontinuation is recommended when planning conception – a precautionary measure rather than a proven necessity.

For women experiencing distressing hair loss, treatment decisions should balance cosmetic benefit with potential but unproven reproductive risk, ideally in consultation with a dermatologist or reproductive health specialist.

Topical minoxidil is one of the most widely used treatments for androgenic alopecia (AGA) in both men and women. While its efficacy and safety as a hair growth stimulant are well established, some men express concern about whether continuing hair loss treatments is safe when trying to conceive. These concerns often stem from known reproductive warnings associated with other medications, particularly finasteride, which directly influences hormonal pathways. Minoxidil, however, works through entirely different mechanisms, enhancing blood flow, prolonging the hair growth phase, and stimulating follicular activity.

This article examines the available scientific evidence to determine whether topical minoxidil has any measurable effect on male fertility. By reviewing preclinical studies, clinical trials, and pharmacologic data, we aim to clarify whether there is any credible link between minoxidil use and changes in reproductive hormones, sperm quality, or conception outcomes.

How Does Minoxidil Work?

Topical minoxidil stimulates hair growth primarily by increasing blood flow and nutrient delivery to hair follicles. Once applied to the scalp, it’s converted by the enzyme sulfotransferase (SULT1A1) into its active metabolite, minoxidil sulfate, which promotes follicular cell proliferation and prolongs the anagen (growth) phase of the hair cycle. It also upregulates vascular endothelial growth factor (VEGF) and activates potassium channels, both of which create a more favorable microenvironment for hair growth.^[1]Suchonwanit, P., Thammarucha, S., & Leerunyakul, K. (2019). Minoxidil and its use in hair disorders: a review. Drug Design, Development and Therapy. 13. 2777-2786. Available at: … Continue reading

Many people choose topical minoxidil over oral formulations because it offers similar local benefits with minimal systemic absorption. This greatly reduces the risk of side effects such as water retention, hypertrichosis (excess body hair), or cardiovascular symptoms sometimes seen with oral minoxidil. As an over-the-counter option with a well-established safety profile, topical minoxidil remains the most accessible first-line treatment for AGA.

Male Fertility: What Matters When Trying to Conceive?

Male fertility is defined as the ability to produce viable sperm capable of fertilizing an egg, and is impacted by a wide range of factors. These include hormonal regulation of sperm production, urogenital abnormalities, genetic factors, and environmental factors such as diet, obesity, and cigarette smoking. Semen quality is the best single snapshot of male reproductive potential. Sperm count influences the statistical odds that enough sperm reach the egg; sperm motility determines whether sperm can traverse cervical mucus, the uterus, and the fallopian tube; and morphology reflects the proportion of intact sperm likely to bind and penetrate the egg. These parameters work together, so clinicians interpret them as a profile rather than in isolation.^[2]StatPearls; Male Infertility. Available at: https://www.ncbi.nlm.nih.gov/books/NBK562258/ (Accessed: October 2025)

Importantly, medications or drugs can influence many aspects of sperm production and function. Certain prescription drugs, such as anabolic steroids, testosterone supplements, finasteride, spironolactone, and some antidepressants or antihypertensives, can suppress the hormonal pathways that regulate spermatogenesis, reducing sperm count or motility. Others may interfere with sperm maturation, DNA integrity, or seminal fluid composition, leading to poorer fertilization potential. Even topical or seemingly localized medications can, in rare cases, exert mild systemic effects that alter reproductive hormones or oxidative balance.^[3]Semet, M., Paci, M., Saïas‐Magnan, J., Metzler‐Guillemain, C., Boissier, R., Lejeune, H., & Perrin, J. (2017). The impact of drugs on male fertility: a review. Andrology. 5(4). 640-663. … Continue reading 

For this reason, men actively trying to conceive are often advised to review all current medications and supplements with a clinician to assess potential reproductive impacts and, if necessary, explore safer alternatives or temporary adjustments.

Systemic Absorption of Topical Minoxidil: How Much Gets In?

Topical minoxidil is designed to act locally on the scalp, with only a small fraction of the drug entering the bloodstream. Studies estimate that around 1-2% of applied minoxidil is systemically absorbed through intact skin, though this can vary depending on factors such as scalp condition, formulation type, and frequency of use. 

For instance, alcohol-based liquid solutions may enhance penetration slightly more than foam preparations, while damaged or inflamed skin can increase absorption. The scalp’s stratum corneum serves as the main barrier, limiting systemic exposure and ensuring that most of the drug remains localized to hair follicles.^[4]Gupta, A. K., Talukder, M., Venkataraman, M., & Bamimore, M. A. (2022). Minoxidil: a comprehensive review. Journal of Dermatological Treatment. 33(4). 1896-1906. Available at: … Continue reading

In contrast, oral minoxidil is fully absorbed into systemic circulation and metabolized in the liver, resulting in significantly higher plasma concentrations of active minoxidil sulfate. This explains why oral therapy, though often more potent, also carries a greater risk of systemic side effects, including edema, tachycardia, and generalized hypertrichosis.^[5]Randolph, M., & Tosti, A. (2021). Oral minoxidil treatment for hair loss: a review of efficacy and safety. Journal of the American Academy of Dermatology. 84(3). 737-746. Available at: … Continue reading Topical use, by comparison, delivers similar follicular benefits with a much lower risk profile, making it the preferred option for those seeking targeted hair regrowth.

Does Topical Minoxidil Affect Male Fertility?

Topical minoxidil might raise concerns for men trying to conceive, as its activity and impact are related to hormonally sensitive pathways. To explore this question properly, we can look at the evidence from laboratory models, human studies, and systematic analyses to understand any potential risks. 

Preclinical Evidence

Other hair loss treatments, such as finasteride, act on hormonal pathways to alter the activity of androgens like testosterone. They may therefore pose a risk to male fertility. As such, it’s important to establish the impact of minoxidil on hormonal factors such as androgen response.

Animal models, particularly those involving rodents and primates, have primarily examined hair cycle dynamics rather than reproductive parameters. These studies consistently show that minoxidil promotes the transition of hair follicles from the telogen (resting) to anagen (growth) phase, enlarges follicular structures, and increases local blood flow. 

One study using golden Syrian hamsters showed that 5% topical minoxidil did not prevent the androgen-dependent growth of pigmented spots, suggesting that minoxidil does not have any effect on androgen response.^[6]Nuck, B. A., Fogelson, S. L., & Lucky, A. W. (1987). Topical minoxidil does not act as an antiandrogen in the flank organ of the golden Syrian hamster. Archives of Dermatology. 123(1). 59-61. … Continue reading 

In contrast, a more recent, small-scale study using rats investigated the impact of topical minoxidil on sperm health. They found that the experimental group, receiving 10% minoxidil, had a 12-13% decline in testicular weight compared to the controls, as well as increases in markers related to oxidative stress within the testicles.^[7]Turkina, V., Chemodurova, N., Hrushka, O., & Pryzyhlei, H. (2020). Topical effect of minoxidil-containing lotion on morphofunctional indicators of male rats’ reproductive system. … Continue reading Unfortunately, the authors do not specify the volume of 10% minoxidil used, making it impossible to make a concrete comparison to normal dosing in humans. This makes the translatability of these toxicology studies more challenging.

Research using cell-based models, including human hair dermal papilla cells, suggests that minoxidil can directly interact with and weaken androgen receptor signaling. However, this study used higher concentrations of minoxidil than would be used in hair loss treatment, and for practical purposes, topical minoxidil remains classified as a non-hormonal treatment.^[8]Hsu, C. L., Liu, J. S., Lin, A. C., Yang, C. H., Chung, W. H., & Wu, W. G. (2014). Minoxidil may suppress androgen receptor‐related functions. Oncotarget. 5(8). 2187-2197. Available at: … Continue reading

Clinical Evidence

While preclinical studies can provide insights into minoxidil activity, evidence for its effect and potential risks should be derived primarily from studies in humans. In clinical settings, topical minoxidil has been studied extensively for AGA, with trials ranging from short-term safety assessments to large randomized controlled trials. Across numerous studies, using 2%, 3%, 5%, and even 10% topical concentrations, the most commonly reported adverse events have been mild scalp irritation, contact dermatitis, or unwanted hair growth on non-target areas.^[10]Olsen, E. A., Dunlap, F. E., Funicella, T., Koperski, J. A., Swinehart, J. M., Tschen, E. H., & Trancik, R. J. (2002). A randomized clinical trial of 5% topical minoxidil versus 2% topical … Continue reading,^[11]Hasanzadeh, H., Nasrollahi, S. A., Halavati, N., Saberi, M., & Firooz, A. (2016). Efficacy and safety of 5% minoxidil topical foam in male pattern hair loss treatment and patient satisfaction. … Continue reading,^[12]Ghonemy, S., Alarawi, A., & Bessar, H. (2021). Efficacy and safety of a new 10% topical minoxidil versus 5% topical minoxidil and placebo in the treatment of male androgenetic alopecia: a … Continue reading 

One randomized trial of 149 subjects reported two cases of impotence during the study, which disappeared following discontinuation of minoxidil treatment.^[13]Rietschel, R. L., & Duncan, S. H. (1987). Safety and efficacy of topical minoxidil in the management of androgenetic alopecia. Journal of the American Academy of Dermatology. 16(3). 677-685. … Continue reading This was the only case of sexual side effects we could find, and it seems to represent a rare complaint. Notably, however, none of these trials have reported reproductive or hormonal disturbances. 

One randomized, controlled study that compared the impact of topical minoxidil alone to a solution containing 0.25% finasteride and 3% minoxidil explicitly monitored sexual side effects. The trial assessed levels of dihydrotestosterone (DHT), a marker for androgen suppression that may be relevant to male fertility. The report found a modest decrease in DHT only in the group who also applied finasteride, suggesting that minoxidil did not impact androgen activity.^[14]Suchonwanit, P., Srisuwanwattana, P., Chalermroj, N., & Khunkhet, S. (2018). A randomized, double-blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride … Continue reading

The largest comparative analysis to date, using the FDA Adverse Event Reporting System (FAERS) data, reinforces these findings. Over ten years of reporting revealed that finasteride was associated with markedly higher rates of erectile dysfunction, decreased libido, and ejaculatory disorders. In contrast, minoxidil, both topical and oral, was not associated with reproductive toxicity in either men or women. Dermatologic reactions such as irritation or dermatitis were the only consistent signals. This post-marketing evidence, covering thousands of patients, supports the conclusion that minoxidil does not interfere with male sexual function or fertility.^[15]Wu, M., Yu, Q., & Li, Q. (2016). Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget. 7(50). 82074-82084. … Continue reading

It is worth noting that most clinical studies do not measure semen parameters, testosterone, or dihydrotestosterone (DHT) levels in participants, so while there is no evidence of harm, data on direct fertility endpoints remain limited. However, trials that have assessed hormonal changes indirectly, such as topical finasteride-minoxidil combinations, report only minimal and clinically insignificant reductions in DHT, well within physiologic ranges and unlikely to impact spermatogenesis. Collectively, this body of evidence supports that topical minoxidil, when used at therapeutic concentrations, exerts its effects locally on hair follicles without meaningful systemic hormonal consequences.

Comparison to Other Hair Loss Treatments

Compared with other medical treatments for hair loss, topical minoxidil has a distinctly favorable reproductive safety profile. Finasteride and dutasteride, both 5-α-reductase inhibitors, work by suppressing the conversion of testosterone to DHT, a potent androgen involved in follicular miniaturization. While effective, this mechanism directly influences sex hormone pathways and has been associated in some users with reduced libido, erectile dysfunction, decreased semen volume, and abnormal sperm morphology.^[16]Gupta, A. K., Venkataraman, M., Talukder, M., & Bamimore, M. A. (2022). Finasteride for hair loss: a review. Journal of Dermatological Treatment. 33(4). 1938-1946. Available at: … Continue reading,^[17]Estill, M. C., Ford, A., Omeira, R., & Rodman, M. (2023). Finasteride and dutasteride for the treatment of male androgenetic alopecia: a review of efficacy and reproductive adverse effects. … Continue reading 

Topical minoxidil, in contrast, exerts no effect on androgen synthesis or receptor binding, acts locally, and is absorbed systemically at rates of roughly 1-2%. Clinical and pharmacologic studies have not detected significant changes in serum hormones, testicular function, or sperm parameters associated with its use. For men attempting to conceive, topical minoxidil is therefore considered the safer option when pharmacologic hair restoration is desired.

Summary Consensus

No systematic reviews or meta-analyses have found an association between topical minoxidil and male reproductive dysfunction. Across clinical trials and pharmacovigilance datasets (such as FAERS), the consensus remains that topical minoxidil poses minimal to no risk to male fertility. Its non-hormonal mechanism stands in contrast to antiandrogenic drugs like finasteride or dutasteride, which are known to suppress DHT levels and can cause sexual side effects in some users. 

The absence of evidence of reproductive toxicity for topical minoxidil is notable given its widespread use over several decades. Still, it is important to acknowledge that the absence of evidence is not definitive proof of absence, and few studies have directly measured sperm quality or fertility outcomes, leaving a modest evidence gap for future research.

Counseling and Clinical Recommendations

Professional society guidelines, including those from the American Academy of Dermatology (AAD), European Academy of Dermatology and Venereology (EADV), and National Institute for Health and Care Excellence (NICE), all recognize topical minoxidil as a first-line treatment for AGA. None include warnings about male fertility or recommend discontinuing treatment when trying to conceive. Recommendations against use in pregnancy and breastfeeding are directed exclusively at women due to potential fetal exposure, not paternal risk.^[18]Olsen, E. A., Sinclair, R., Hordinsky, M., Mesinkovska, N. A., Sadick, N., Shapiro, J., & Bergfeld, W. (2025). Summation and recommendations for the safe and effective use of topical and oral … Continue reading

In clinical practice, dermatologists generally reassure male patients that topical minoxidil can be safely continued when planning conception. They may, however, emphasize good application hygiene, using the prescribed dose, applying only to the scalp, washing hands afterward, and allowing the product to dry fully before physical contact to prevent unintended transfer to partners or infants. Because systemic absorption is minimal, these precautions are primarily to avoid topical irritation rather than systemic effects. 

Myths and Misconceptions About Topical Minoxidil and Fertility

Given the links between minoxidil activity and hormonally sensitive pathways related to hair loss, some men may have concerns about using the medication when trying to conceive. Let’s look at some of the potential misconceptions about topical minoxidil and fertility.

Topical minoxidil causes infertility

There is some limited evidence from animal studies suggesting that topical minoxidil may affect sperm quality.^[19]Turkina, V., Chemodurova, N., Hrushka, O., & Pryzyhlei, H. (2020). Topical effect of minoxidil-containing lotion on morphofunctional indicators of male rats’ reproductive system. … Continue reading However, there is no evidence that topical minoxidil reduces sperm count, motility, or morphology. Clinical trials of 3%, 5%, and 10% minoxidil report vanishingly few reproductive or hormonal side effects. The drug acts locally on the scalp, with systemic absorption of only about 1–2%, far below levels that could influence reproductive physiology. Neither animal studies nor human trials have identified any fertility-related toxicity associated with topical minoxidil use.

Topical minoxidil alters male hormone levels

Studies suggest that minoxidil does not interfere with androgen production, metabolism, or receptor binding at doses relevant for hair loss. It promotes hair growth through vascular and cellular mechanisms, such as increasing VEGF expression and opening potassium channels, not by modifying testosterone or dihydrotestosterone (DHT) pathways. 

However, some research using cell-based models has suggested that minoxidil might impact androgen receptor activity at high concentrations.^[20]Hsu, C. L., Liu, J. S., Lin, A. C., Yang, C. H., Chung, W. H., & Wu, W. G. (2014). Minoxidil may suppress androgen receptor‐related functions. Oncotarget. 5(8). 2187-2197. Available at: … Continue reading

Topical minoxidil causes erectile dysfunction

Sexual side effects are very rarely reported in any major clinical trials or pharmacovigilance data concerning topical minoxidil, with only two cases of impotence associated with topical minoxidil reported in the literature. Erectile dysfunction, decreased libido, and ejaculatory changes are associated with oral 5-α-reductase inhibitors (such as finasteride), not with topical minoxidil.^[21]Wu, M., Yu, Q., & Li, Q. (2016). Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget. 7(50). 82074-82084. … Continue reading

Fertility risks are the same for all hair loss drugs

Different hair loss treatments have fundamentally different mechanisms. Finasteride and dutasteride lower DHT and can influence sexual function and semen parameters in some users.^[22]Estill, M. C., Ford, A., Omeira, R., & Rodman, M. (2023). Finasteride and dutasteride for the treatment of male androgenetic alopecia: a review of efficacy and reproductive adverse effects. … Continue reading Minoxidil, on the other hand, does not interact with the androgen pathway and has no known reproductive risks. Therefore, the fertility profile of topical minoxidil is significantly safer than that of antiandrogenic agents.

Final Thoughts

Topical minoxidil remains one of the safest and most accessible treatments for male pattern hair loss, with decades of research supporting its efficacy and tolerability. Unlike hormone-modulating therapies such as finasteride, minoxidil works through non-androgenic pathways and shows no evidence of affecting male fertility, hormone levels, or sexual function. While future studies could further clarify long-term reproductive outcomes, the current consensus is clear: topical minoxidil is a fertility-neutral, first-line option for men looking to manage hair loss safely.

Finasteride is widely used for androgenic alopecia (AGA) and benign prostate hyperplasia (BPH). It’s generally well tolerated, with most users experiencing no significant adverse effects.   However, clinicians in eye clinics have reported occurrences of dry eye that could be related to the use of finasteride.^[1]NZ Optics. (2022). Finasteride and dry eye disease. Available at: https://www.nzoptics.co.nz/live-articles/finasteride-and-dry-eye-disease/ (Accessed: October 2025) 

Dry eye disease (DED) is a common eye disorder characterized by insufficient tear production or poor tear quality. This can cause inadequate lubrication of the eye’s surface, leading to discomfort, irritation, and potentially damage to the eye. The condition is multifactorial, meaning it can be caused by a number of different factors. One important cause is increased tear evaporation, leading to evaporative dry eye. The quality and structure of tears are regulated by hormonal pathways, meaning that the anti-androgenic activity of finasteride could drive the development of the condition.^[2]Golden, M. I., Meyer, J. J., Zeppieri, M., & Patel, B. C. (2024). Dry Eye Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available at: … Continue reading

In this article, we will examine the research that links finasteride to dry eye disease and explore the potential mechanisms by which it may be contributing to the condition. 

Finasteride and the Eye

Finasteride is a 5α-reductase inhibitor and works by reducing the conversion of testosterone to dihydrotestosterone (DHT). DHT drives the shrinking and weakening of hair follicles in AGA, meaning that finasteride activity can counteract these effects by decreasing the amount of DHT. Finasteride is typically administered orally, meaning it can have systemic effects on multiple parts of the body. This is particularly important in tissues that are sensitive to androgens like DHT.^[3]Zito, P. M., Bistas, K. G., Patel, P., & Syed, K. (2024). Finasteride. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available at: … Continue reading

The meibomian glands are one such tissue. They are special sebaceous (oil-producing) glands located within the upper and lower eyelids, with each eye containing 20 – 40 of these glands. They produce meibum, a lipid-rich secretion that forms the outermost layer of the tear film and plays a critical role in maintaining ocular surface health. With every blink, meibum is expressed from the gland orifices, forming a thin, uniform layer over the eye. Meibum’s main function is to prevent evaporation of the tear film by creating a stable oil barrier, ensuring long-lasting lubrication of the eye’s surface.^[5]Sabeti, S., Kheirkhah, A., Yin, J., & Dana, R. (2020). Management of meibomian gland dysfunction: a review. Survey of Ophthalmology. 65(2). 205-217. Available at: … Continue reading

Meibomian glands are directly regulated by androgens, via receptors present in their epithelial cells. Androgens, such as DHT, can bind to these receptors, directly influencing the synthesis of lipids essential for tear formation. Importantly, DHT is also synthesized in meibomian glands by 5α-reductase. This is where the connection to finasteride comes in: inhibition of 5α-reductase by the drug could stop DHT activity in the meibomian glands, stopping the production of lipids required to prevent tear evaporation. As such, while finasteride doesn’t target the eye, its impact on androgen pathways can have indirect effects.^[7]Traish, A. M. (2020). Health risks associated with long-term finasteride and dutasteride use: it’s time to sound the alarm. The World Journal of Men’s Health. 38(3). 323-337. Available at: … Continue reading

Even partial androgen suppression, like oral finasteride for hair, could be enough to impact tear production, particularly in someone who has other risk factors associated with DED, such as older age, prolonged screen time, certain medications (antihistamines, antidepressants, diuretics, beta-blockers), autoimmune or connective tissue diseases, and environmental exposures such as wind, dry climates, or smoke.

Do DHT-Reducing Therapies Lead to Dry Eye?

A role for androgens in regulating meibomian gland function was proposed in a paper published in 2000.^[8]Krenzer, K. L., Reza Dana, M., Ullman, M. D., Cermak, J. M., Tolls, D. B., Evans, J. E., & Sullivan, D. A. (2000). Effect of androgen deficiency on the human meibomian gland and ocular surface. … Continue reading Patients who were taking antiandrogen drugs for issues related to the prostate were assessed on symtpoms of DED and the contents of their meibomian gland secretions. They were compared to a control group that was on such medications. They found that antiandrogen therapy changes the composition of lipids in tears, while also decreasing the quality of tears and increasing participants’ susceptibility to light sensitivity, painful eyes, and blurred vision. This study laid the foundation for our current understanding of how DHT-lowering therapies might cause DED. 

Preclinical Data

Animal models have been developed to understand the mechanisms that lead to DED, including a potential role for DHT-lowering therapies as suggested by these clinical findings. A 2014 study utilized a rat model to investigate the impact of finasteride on tear production.^[9]Singh, S., Moksha, L., Sharma, N., Titiyal, J. S., Biswas, N. R., & Velpandian, T. (2014). Development and evaluation of animal models for sex steroid deficient dry eye. Journal of … Continue reading They found that oral administration of 1.6 mg/kg finasteride every day significantly decreased tear flow and increased the speed at which tears break up after 10 days in both male and female rats.

This study was supported by further research published in 2017, which used the same concentration of finasteride in rats for 40 days.^[10]Li, K., Zhang, C., Yang, Z., Wang, Y., & Si, H. (2017). Evaluation of a novel dry eye model induced by oral administration of finasteride. Molecular Medicine Reports. 16(6). 8763-8770. Available … Continue reading They also found that tear production was reduced in finasteride-treated rats, and makers for tear break-up were increased. The impact of finasteride on tear production in rats is so reliable that it has been used to induce DED in models investigating potential treatments for the condition.^[11]Zhang, C., Li, K., Yang, Z., Wang, Y., & Si, H. (2016). The effect of the aqueous extract of Bidens pilosa L. on androgen deficiency dry eye in rats. Cellular Physiology and Biochemistry. 39(1). … Continue reading

Notably, these animal models use considerably higher concentrations of finasteride than would be recommended for hair loss – an equivalent dose for the average American man would be around 126 mg per day. In comparison, the standard regimen for AGA is only 1 mg per day. However, they do demonstrate the capacity for finasteride to impact tear production.

Clinical Data

Preclinical data, as well as a deeper understanding of the androgen-associated causes of DED, led to some concern about the potential adverse effects of finasteride.^[13]Traish, A. M. (2020). Health risks associated with long-term finasteride and dutasteride use: it’s time to sound the alarm. The World Journal of Men’s Health. 38(3). 323-337. Available at: … Continue reading 

Recently, clinical researchers have further explored this link. A retrospective case series looked at 116 patients at an eye clinic with a history of DED who were taking finasteride.^[14]Nguyen, B. J., Meer, E., Gupta, A. S., Jinpeng, G., Ying, G. S., Bunya, V. Y., Macchi, I., & Massaro-Giordano, M. (2022). The effect of finasteride on dry eye disease. Investigative Ophthalmology … Continue reading 

They found that a significantly greater proportion of patients had MGD, conjunctival abnormalities, and corneal abnormalities during follow-up examinations compared to their initial assessment, a period of four and a half years on average. 

They also found a trend toward increased disease severity in patients on a higher dose of finasteride, although these findings were not statistically significant. It is hard to draw any conclusions from this research, as it only looked at individuals who both took finasteride and had DED. A retrospective study or clinical trial that included individuals who did not take finasteride would provide significantly greater insights.

Anecdotal reports from an eye clinic in New Zealand have indicated that increasingly, patients presenting with DED are also taking finasteride.^[15]NZ Optics. (2022). Finasteride and dry eye disease. Available at: https://www.nzoptics.co.nz/live-articles/finasteride-and-dry-eye-disease/ (Accessed: October 2025)  Data on the impact of finasteride on DED is, therefore, lacking, and robust clinical studies are required to better understand the potential link.

Some conclusions can also be drawn from clinical studies investigating other antiandrogenic drugs. Such medications are often used against prostate cancer, which depends on androgens such as testosterone and DHT for its growth and survival. A retrospective study compared a group of 1791 patients with prostate cancer who were taking a range of androgen deprivation therapies with those who weren’t.^[16]Chien, H. W., Lin, C. W., Lee, C. Y., Huang, J. Y., Yang, S. F., & Wang, K. (2022). The use of androgen deprivation therapy for prostate cancer and its effect on the subsequent dry eye disease: a … Continue reading They found no significant difference in the development of DED.

A similar study compared a smaller group of prostate cancer patients on antiandrogens (31 in total) to those not on such medications. However, it investigated tear formation in greater depth.^[17]Kurna, S. A., Hacisalihoglu, A. O., Altun, A., Ozel, N. O., Uruc, F., Kanar, H. S., & Arsan, A. K. (2022). Effects of systemic anti-androgen drugs on the ocular surface. Journal Français … Continue reading 

They found a significant increase in markers for tear break-up and complaints of dry eye. Importantly, neither of these studies distinguishes between forms of antiandrogen therapy, nor do they specifically investigate the role of finasteride.

Summary Consensus

Data from animal models provide a clear mechanism by which finasteride could impact tear production and cause MGD and DED. However, the limited availability of clinical data makes it challenging to draw evidence-based conclusions about the potential adverse effects of finasteride. Clinical studies using a wide range of antiandrogen therapies in a different cohort (prostate cancer patients) also provide conflicting information. It’s important to remember that the absence of evidence doesn’t mean definitive proof of absence, and you should still consider the potential effects on your eyes when taking finasteride.

How Might Finasteride Cause Dry Eye?

1. Finasteride reduces DHT: Finasteride blocks 5α-reductase, lowering dihydrotestosterone (DHT) levels in the body.
2. Decreased androgen activity in eyelid glands: Lower DHT means less stimulation of the meibomian glands, which rely on androgens to produce the oils that keep tears in place.
3. Reduced meibum quality and quantity: With reduced androgen influence, these glands produce less oil, thereby decreasing the stability of the tear film.
4. Gland obstruction and dysfunction: Poor-quality meibum can clog gland openings, leading to meibomian gland dysfunction and reduced tear protection.
5. Evaporative tear loss and dry eye symptoms: Tears evaporate more quickly, causing dryness, irritation, and blurred vision.

Secondary effects – Inflammation and surface damage: Ongoing tear film instability can trigger inflammation, discomfort, and damage to the eye’s surface over time.

Who Might Be Most At Risk of DED?

If you’re concerned about the risk of developing DED while taking finasteride, it’s important to consider other risk factors that could have an additive effect.^[18]Britten-Jones, A. C., Wang, M. T., Samuels, I., Jennings, C., Stapleton, F., & Craig, J. P. (2024). Epidemiology and risk factors of dry eye disease: considerations for clinical management. … Continue reading Those at risk include:

Peri-and Post Menopausal Women – The hormonal changes of menopause lead to reduced secretion and quality in both lacrimal and meibomian glands, the core tear-producing tissues

Older People – The risk sharply increases after age 40, with prevalence rising further with each decade due to reduced tear production and gland function.

Contact Lens Wearers – Long-term use is linked to higher DED risk due to tear film disruption.

Screen Users – Reduced blink rate and incomplete blinks from device use elevate risk, especially in professional and urban populations.

Individuals on Certain Medications – Antihistamines, antidepressants, hormone therapies, and diuretics reduce tear secretion or alter tear composition.

People Exposed to Dry, Polluted, or Urban Environments – Low ambient humidity, air conditioning, pollution, and smoke contribute to increased evaporation and instability of the tear film.

How Can I Manage or Prevent Dry Eye While on Finasteride?

Dry eye can often be managed through a combination of lifestyle changes, environmental adjustments, proper eye care, and medical support.^[19]Donthineni, P. R., Shanbhag, S. S., & Basu, S. (2021). An evidence-based strategic approach to prevention and treatment of dry eye disease, a modern global epidemic. Healthcare. 9(1). 89. … Continue reading If you’re taking finasteride and notice eye discomfort or dryness, these steps may help minimize symptoms and protect long-term eye health.

• Avoid smoky environments and consider quitting smoking. Both active and passive smoke can worsen dryness and irritation.
• Take regular eye breaks. Blinking more often and positioning screens slightly below eye level can also help reduce tear evaporation.
• Clean your eyelids daily using a warm compress followed by gentle cleansing with a mild, non-irritating lid cleanser. This can help keep oil glands functioning correctly, especially if you have blepharitis or meibomian gland dysfunction (MGD).
• Apply lubricating eye drops to keep the eyes moist and comfortable.
• Boost your intake of omega-3s through foods such as salmon, mackerel, walnuts, and flaxseed, or consider supplements under your doctor’s guidance. These healthy fats support meibomian gland function and tear quality.
• Protect your eyes from UV rays and dust by wearing sunglasses outdoors. Avoid rubbing your eyes, get sufficient sleep, and maintain a balanced diet rich in vitamins A, C, and E.
• If dryness, irritation, or visual changes continue, see an ophthalmologist or optometrist. They can assess tear quality and meibomian gland health, and may recommend advanced treatments such as prescription eye drops.

What’s Still Unknown

Although preclinical and clinical evidence suggest a possible link between finasteride and DED, many questions remain unanswered. Animal models suggest a causal connection but cannot replicate human physiology, and typically administer much higher doses than those that would be administered in humans. Large, controlled trials investigating the use of finasteride at the 1 mg hair-loss dose are required to draw evidence-based conclusions about the role of finasteride in DED.

Final Thoughts

Finasteride is an effective, well-established, and typically well-tolerated treatment for hair. However, concerns about links to meibomian gland dysfunction and DED are rising. The eye is a hormonally responsive organ, and systemic medications can have subtle but meaningful effects on ocular health. While animal studies and hormonal mechanisms support a potential link to dry eye disease, human data remain limited and inconclusive, especially at the low doses used for androgenic alopecia. For now, users should monitor for symptoms like dryness or irritation and seek ophthalmologic advice if they occur. 

Testosterone replacement therapy (TRT) can be a life-changing treatment for many men, restoring healthy hormone levels and renewing vitality after declines associated with low testosterone. However, many encounter a harsh irony: the same treatment that revitalizes them may also lead to accelerated hair loss, known as androgenetic alopecia (AGA). This frustrating dilemma can compel some men to choose between their appearance and their health. 

Why do TRT patients often experience hair thinning just months into treatment? The culprit is testosterone’s conversion to DHT, the hormone that drives male pattern hair loss. Fortunately, new developments in comprehensive care address the testosterone-to-hair-loss pathway, allowing men to enjoy both hormone optimization and healthy hair. These clinically rigorous, customizable, and medically supervised treatments eliminate the either-or paradox.

Perfect Hair Health’s PhD experts have teamed up with Ulo, a leader in men’s wellness and hair care, to share five evidence-based techniques for preserving hair while on TRT. With Ulo’s unique expertise at the intersection of hormone optimization and hair restoration, patients gain access to solutions that are both proven and personalized.

Read on to learn how Ulo can help you maintain both hormonal health and hair density.

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The Science of Testosterone and Hair Loss 

Before exploring solutions, we will briefly explain the science behind TRT and hair loss, including relevant medical research that supports prevention-based strategies for preserving hair during TRT.

Testosterone Metabolism and DHT Formation

To understand the link between TRT and hair loss, we turn to the molecular process that converts testosterone into dihydrotestosterone (DHT), the hormone that causes follicular degradation and balding. Two types of 5α-reductase enzymes are responsible for deriving DHT from testosterone: Type I (primarily located in the skin and sebaceous glands) and Type II (mainly located in the hair follicles of the crown and temporal regions).^[1]Owecka, B., Tomaszewska, A., Dobrzeniecki, K., Owecki, M. (2024). The Hormonal Background of Hair Loss in Non-Scarring Alopecias. Biomedicines. 12(3). 513. Available at: … Continue reading

Androgenetic alopecia (AGA) can occur naturally in susceptible individuals, whose hair follicles have high concentrations of androgen receptors and 5α-reductase enzymes. However, adding exogenous T through TRT can expedite this process. TRT’s elevation of testosterone levels can raise DHT to two or three times higher than starting levels, depending on the dosage and mode of application. The conversion of T to DHT is especially prevalent in the crown and temporal areas of the scalp, where it causes hair thinning and loss.^[2]Owecka, B., Tomaszewska, A., Dobrzeniecki, K., Owecki, M. (2024). The Hormonal Background of Hair Loss in Non-Scarring Alopecias. Biomedicines. 12(3). 513. Available at: … Continue reading,^[3]Stocks, B., Asempa, O. (2025). Does testosterone replacement therapy cause hair loss? Baylor College of Medicine. Available at: … Continue reading

Genetic predisposition plays a significant role, as variations in androgen receptor genes determine individual sensitivity to DHT. This explains why patients on identical TRT regimens can experience varying levels of hair loss, with some experiencing dramatic loss and others experiencing little or no effect. In those with hereditary androgen sensitivity, the hair follicles respond poorly to even slight elevations in local DHT levels on the scalp.^[4]Owecka, B., Tomaszewska, A., Dobrzeniecki, K., Owecki, M. (2024). The Hormonal Background of Hair Loss in Non-Scarring Alopecias. Biomedicines. 12(3). 513. Available at: … Continue reading

Why TRT Accelerates Pattern Hair Loss

As previously noted, TRT increases testosterone and leads to higher levels of its derivative hormone, DHT, which binds to hair follicles and causes hair thinning and loss in genetically susceptible men. Spikes in DHT and associated hair loss can occur even with moderate TRT, as raising testosterone into the normal range can represent a significant increase from severe deficiency.^[5]Borst, S.E., Shuster, J.J., Zou, B., Ye, F., Jia, H., Wokhlu, A., Yarrow, J.F. (2014). Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systemic review … Continue reading  

Episodic TRT protocols like weekly injections can create testosterone peaks over 1,200 ng/dL for up to 48 hours after injection, leading to surges in scalp DHT production during these windows. Such DHT spikes can damage the follicles and contribute to rapid hair loss.^[6]Stocks, B., Asempa, O. (2025). Does testosterone replacement therapy cause hair loss? Baylor College of Medicine. Available at: … Continue reading,^[7]Shoskes, J.J., Wilson, M.K., Spinner, M.L. (2016). Pharmacology of testosterone replacement therapy preparations. Translational Andrology and Urology. 5(6). 834-843. Available at: … Continue reading 

Disruption of hair follicle cycles can begin in the first 3-6 weeks of TRT. However, noticeable hair loss typically doesn’t emerge for several months, as early damage is concealed by hair growth cycles. Studies suggest higher TRT doses correlate with more rapid hair loss in susceptible patients.^[8]Saad, F., Aversa, A., Isidori, A.M., Zafalon, L., Zitzmann, M., Gooren, L. (2011). Onset of effects of testosterone treatment and time span until maximum effects are achieved. European Journal of … Continue reading,^[9]Fu, D., Huang, J., Li, K., Chen, Y., He, Y., Sun, Y., Guo, Y., Du, L., Qu, Q., Miao, Y., Hu, Z. (2021). Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 … Continue reading

Balancing Hormonal Benefits with Hair Protection

Although DHT can harm the hair follicles, it plays a vital role in various biological processes, including sexual function, bone mineralization, and muscle development. Therefore, the aim of hair loss treatment during TRT is not to eliminate the hormone. Rather, the therapeutic goal is to lower DHT to a level that minimizes follicular damage while preserving systemic functions. Striking this balance in individuals often requires sophisticated strategies that exceed standardized DHT suppression protocols.^[10]Owecka, B., Tomaszewska, A., Dobrzeniecki, K., Owecki, M. (2024). The Hormonal Background of Hair Loss in Non-Scarring Alopecias. Biomedicines. 12(3). 513. Available at: … Continue reading 

While some patients may be tempted to terminate TRT to protect their hair, research findings support a more measured approach that takes TRT’s broader benefits into account. Patients who elect to stop taking testosterone for hair preservation may experience a return of detrimental symptoms: sexual dysfunction, depression, fatigue, muscle loss, and more. The psychological and physiological impacts of low T can outweigh cosmetic concerns.

Given these considerations, practitioners advise strategic early intervention over reactionary care, as hair restoration becomes much more challenging after considerable follicular shrinkage. Early discussion with healthcare providers about hair preservation strategies helps maintain hair health throughout the hormone optimization process.^[11]Owecka, B., Tomaszewska, A., Dobrzeniecki, K., Owecki, M. (2024). The Hormonal Background of Hair Loss in Non-Scarring Alopecias. Biomedicines. 12(3). 513. Available at: … Continue reading 

With the science behind TRT and hair loss clear, let’s look at the latest, evidence-based ways patients can protect their hair.

Expert Solutions for TRT-Related Hair Loss

Hair loss associated with TRT often has distinct features, like episodic spikes in testosterone and DHT conversion rates. Although conventional hair loss interventions can be useful, protocols may benefit from personalization according to TRT regimens.

Ulo is a unique provider due to its innovative hair loss treatments and dual expertise in both hair restoration and hormone optimization. This combined clinical experience enables them to tailor treatments to individual patient needs, such as timing factors and treatment responses specific to TRT. All Ulo treatment protocols are physician-crafted and include close follow-up care to monitor for side effects and make adjustments as needed.

Treatment Options Overview

This overview outlines Ulo’s comprehensive strategy for hair loss intervention, from advanced prescription formulas to targeted nutritional support. All offerings are transparently priced with customizable features to account for TRT-related factors and individual patient considerations.

Product Category	Mechanism of Action	Delivery Method	Formula Details	Price
Oral Medications	Systemic 5α-reductase inhibition and vasodilation	Oral capsule, tablet, or softgel	Finasteride, dutasteride, and minoxidil for systemic DHT blocking and growth stimulation	$24-65/month
Topical Finasteride	Localized Type II 5α-reductase inhibition with minimal systemic exposure	Solution	Concentration range (0.005%-0.2%); customizable adjuvants; irritant-free	$64+/month
Topical Dutasteride	Localized dual enzyme (Types I & II) inhibition for maximum scalp DHT suppression	Solution	Concentration range (0.02%-0.2%); customizable adjuvants; irritant-free	$84+/month
Growth Booster Topicals	Vasodilation, anti-inflammatory action without DHT manipulation	Solution	Customizable combinations of minoxidil, tretinoin, caffeine, melatonin, and cetirizine	$54/month
OTC Support Products	Nutritional optimization, scalp environment enhancement, and daily follicular support	Serum, supplements, shampoo, and conditioner	Evidence-based supplements targeting TRT-specific deficiencies; irritant-free hair care products	$29+/month

Method #1: Oral Medications for Systemic Effects

Why Choose Oral Treatment?

This systemic approach provides several key advantages for men on testosterone therapy:

Benefit:	Details:
✓ Comprehensive treatment	Systemic DHT blocking plus vasodilation for growth stimulation
✓ Maximum potency	Up to 93% DHT reduction with dutasteride
✓ Convenience	Once-daily dosing
✓ Customizable	Combination options with growth stimulators

How Do Oral Medications Work to Treat Hair Loss?

DHT blockers like finasteride and dutasteride treat hair loss by suppressing the 5α-reductase enzymes that metabolize testosterone into DHT. Oral preparations have systemic effects and therefore offer extensive treatment. They can be used in conjunction with oral growth stimulators, such as minoxidil, to minimize hair loss associated with TRT. 

Finasteride inhibits the Type II 5α-reductase enzyme to reduce DHT levels by up to 70%. In contrast, dutasteride is a more potent intervention as a dual inhibitor of both Type I and Type II 5α-reductase enzymes, achieving up to 93% lower DHT levels. This thorough DHT suppression can make dutasteride useful for advanced hair loss cases as well as high-dose TRT patients who may not respond to topical treatments.^[12]Arif, T., Dorjay, K., Adil, M., Sami, M. (2017). Dutasteride in Androgenetic Alopecia: An Update. Current Clinical Pharmacology. 12(1). 31-35. Available at: … Continue reading 

Studies indicate that dutasteride’s therapeutic effects may continue to build beyond the 12 months at which many finasteride users experience a plateau, further establishing dutasteride as the most potent treatment option. While oral DHT blockers offer powerful treatment, their systemic effects contribute to a greater risk of serious side effects, so strict medical oversight is required.^[13]Harcha, W.G., Martinez, J.B., Tsai, T-F., Katsuoka, K., Kawashima, M., Tsuboi, R., Barnes, A., Ferron-Brady, G., Chetty, D. (2014). A randomized, active- and placebo-controlled study of the efficacy … Continue reading

Ulo’s Oral Medication Approach

Ulo’s oral treatments offer effective systemic intervention through various formulations designed for optimal bioavailability, featuring customizable options. Their oral Dutasteride Rx delivers a 0.5 mg dose of dual enzyme-blocking treatment in a softgel format designed to enhance absorption, overcoming the poor bioavailability of powder formulas touted by competitors.  

Their gentler oral Finasteride Rx also offers systemic DHT suppression in a once-daily capsule, while an oral Minoxidil Rx (1.25 mg or 2.5 mg) tablet formula increases systemic circulation and upregulates hair growth factors to treat hair loss as an alternative to DHT-blocking medications. 

Ulo also offers oral preparations that synergistically combine DHT blockers with minoxidil for effects that are shown to exceed those of monotherapies: Dutasteride + Minoxidil Rx and Finasteride + Minoxidil Rx, which come with optional adjuvants like vitamin D and folic acid to address deficiencies. Rather than combining oral dutasteride and minoxidil into a single capsule, as competitors do, Ulo maintains a separate soft gel and powder format for each, enabling proper absorption. 

Key Takeaway: Oral medications such as finasteride, dutasteride, and minoxidil provide the strongest systemic protection against hair loss during TRT, but their broad effects mean they require careful medical supervision to manage potential side effects.

Method #2: Topical Finasteride for Precision DHT Blocking

Why Choose Topical Finasteride?

Topical finasteride offers these strategic benefits for TRT patients:

Benefit:	Details:
✓ Targeted action	Scalp-focused DHT reduction
✓ Flexible dosing	Low-dose (0.005%) and full-strength (0.2%) options
✓ Safer alternative to oral	Comparable efficacy to oral without systemic exposure side effects
✓ Customizable	Optional minoxidil and adjuvant combinations

How Does Topical Finasteride Work?

Topical finasteride delivers targeted DHT suppression directly to the scalp, minimizing effects on the rest of the body. Studies show that topical finasteride can reduce scalp DHT to a therapeutic effect with little impact on serum DHT levels. In contrast, oral finasteride reduces DHT levels throughout the entire system. For men on TRT, maintaining systemic DHT is essential for bone, muscle, and sexual health; therefore, topical finasteride is typically the preferred option.^[14]Kinter KJ, Amraei R, Anekar AA. Biochemistry, Dihydrotestosterone. [Updated 2023 Jul 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: … Continue reading,^[15]Piraccini, B.M., Blume-Peytavi, U., Scarci, F., Jansat, J.M., Falques, M., Otero, R., Tamarit, M.L., Galvan, J., Tebbs, V., Massana, E. (2021). Efficacy and safety of topical finasteride spray … Continue reading

Topical formulations also allow more precise dosing with flexible concentrations that can be tailored to patient needs and responses. Low-dose formulas (0.005%) may be more appropriate for early-stage or moderate TRT patients, while higher-strength options (0.2%) can offer more aggressive treatment for substantial hair loss or intensive TRT protocols. Topical solutions can easily incorporate elective adjuvants, such as absorption enhancers and anti-inflammatories, for synergistic benefits.^[16]Kinter KJ, Amraei R, Anekar AA. Biochemistry, Dihydrotestosterone. [Updated 2023 Jul 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: … Continue reading

Ulo’s Topical Finasteride System

Ulo’s topical finasteride solution provides targeted scalp treatment with an optimized delivery base that is free from potential irritants, such as propylene glycol. Their fully customizable Finasteride + Minoxidil Plus Rx is available in finasteride doses of 0.005% for gentler therapy and 0.2% for stronger intervention. 

The robust formulation includes a wide range of synergistic add-on choices that address multiple hair loss pathways: up to 7% minoxidil for growth stimulation, tretinoin for better absorption, and multiple antioxidants for comprehensive support. This adaptability enables treatment tailored to patient needs rather than fixed protocols. Physician-crafted and supervised topical protocols are considered safe and effective for prolonged use to complement TRT journeys.

Key Takeaway: Topical finasteride allows TRT patients to lower scalp DHT while preserving systemic androgen function, making it a preferred option for balancing hair health with hormonal benefits.

Method #3: Topical Dutasteride for Comprehensive Scalp Protection

Why Choose Topical Dutasteride?

This powerful topical approach delivers distinct advantages:

Benefit:	Details:
✓ Dual enzyme blocking	Inhibits both Type I and Type II 5α-reductase
✓ Max scalp DHT reduction	Superior enzyme inhibition for aggressive protocol
✓ Safe and targeted treatment	Potent effects without systemic exposure
✓ Concentration control	Low-dose (0.02%) to full-strength (0.2%) options
✓ Personalized add-ons	Adjuvants can be tailored to individual needs

How Does Topical Dutasteride Work?

Topical dutasteride leverages the dual enzyme inhibition and localized efficacy discussed in Methods 1 and 2 to powerfully suppress scalp DHT levels while maintaining systemic DHT. This approach can be beneficial for patients on intensive TRT protocols that don’t respond to single-enzyme-blocking treatments. 

The superior targeted DHT suppression of topical dutasteride makes it an excellent choice for severe hair loss and TRT scenarios. It is the most potent topical DHT blocker available. Like topical finasteride, its concentration flexibility and easy incorporation of adjuvants enable more highly tailored and adaptable treatment compared to oral administration.^[17]Arif, T., Dorjay, K., Adil, M., Sami, M. (2017). Dutasteride in Androgenetic Alopecia: An Update. Current Clinical Pharmacology. 12(1). 31-35. Available at: … Continue reading,^[18]Harcha, W.G., Martinez, J.B., Tsai, T-F., Katsuoka, K., Kawashima, M., Tsuboi, R., Barnes, A., Ferron-Brady, G., Chetty, D. (2014). A randomized, active- and placebo-controlled study of the efficacy … Continue reading,^[19]Obeid, M., Fattah, N., Elfangary, M., & Husseni, R. (2024). Comparison between topical minoxidil 5% alone versus combined with dutasteride (topical 0.02% through microneedling or oral 0.5 mg) in … Continue reading

Ulo’s Topical Dutasteride Excellence

Ulo’s topical dutasteride offerings include both low-dose (0.02%) and full-strength (0.2%) versions of their Dutasteride + Minoxidil Plus Rx solution, delivering potent dual enzyme inhibition for precision scalp treatment. While the lower concentration may suit maintenance or preventative protocols, the highly concentrated formula may benefit severe hair loss patients and aggressive TRT regimens. 

Like Ulo’s topical finasteride products, their dutasteride selections are fully customizable with synergistic add-ons that include minoxidil (up to 7%), caffeine, tretinoin, cetirizine, and melatonin. The clinically backed formulas are designed to deeply penetrate the scalp and follicles without the use of irritants, corticosteroids, or unproven ingredients seen in competing premium brands. 

The platform’s Build Your Own Topical feature offers complete customization across the full range of topical electives, including a choice of finasteride or dutasteride with individualized adjuvant combinations. 

Key Takeaway: Topical dutasteride delivers the most powerful scalp-targeted DHT reduction available and is well-suited for men with significant hair loss or intensive TRT regimens that do not respond to other approaches.

Method #4: Growth Booster Topicals for Non-Hormonal Treatment

Why Choose Growth Booster Topicals?

Non-hormonal growth stimulation provides these unique benefits:

Benefit:	Details:
✓ Hormone-free treatment	Growth stimulation without hormonal manipulation
✓ Anti-inflammatory	Addresses scalp inflammation contributing to hair loss
✓ High-strength formulas	7% minoxidil with absorption enhancers
✓ Versatile use	Standalone or in combination with DHT blockers

How Do Growth Booster Topicals Work?

Growth stimulators are useful for comprehensive hair restoration during TRT to address non-hormonal hair loss pathways outside of DHT’s purview. Minoxidil is one of the most commonly used medications, acting as a vasodilator to boost scalp circulation while upregulating growth factors to extend the anagen phase of each hair cycle.^[20]Obeid, M., Fattah, N., Elfangary, M., & Husseni, R. (2024). Comparison between topical minoxidil 5% alone versus combined with dutasteride (topical 0.02% through microneedling or oral 0.5 mg) in … Continue reading,^[21]Koralewicz, M.M., Szatkowska, O.A. (2024). Topical solutions for androgenetic alopecia: evaluating efficacy and safety. Forum Dermatologicum. 10(3). 71-78. Available at: … Continue reading

Calming agents like cetirizine, melatonin, and caffeine address scalp inflammation, another key contributor to follicular damage and hair loss. Caffeine also enhances follicular nutrient supply to act as a growth stimulant, while melatonin’s antioxidant protection reduces shedding.^[22]Koralewicz, M.M., Szatkowska, O.A. (2024). Topical solutions for androgenetic alopecia: evaluating efficacy and safety. Forum Dermatologicum. 10(3). 71-78. Available at: … Continue reading

The powerful combination of growth stimulation with anti-inflammatory action can provide standalone benefits or be applied as a complementary therapy with DHT blockers. Studies show that minoxidil is effectively combined with DHT blockers, offering greater outcomes than single-agent therapies. Growth boosters are therefore vital to the success of TRT hair loss prevention protocols.^[23]Obeid, M., Fattah, N., Elfangary, M., & Husseni, R. (2024). Comparison between topical minoxidil 5% alone versus combined with dutasteride (topical 0.02% through microneedling or oral 0.5 mg) in … Continue reading,^[24]Koralewicz, M.M., Szatkowska, O.A. (2024). Topical solutions for androgenetic alopecia: evaluating efficacy and safety. Forum Dermatologicum. 10(3). 71-78. Available at: … Continue reading

Ulo’s Growth Booster Solutions

Ulo offers two customizable growth stimulation topicals that can be used alone or in conjunction with DHT blockers, depending on the prescribed protocol. Their Minoxidil + Tretinoin Plus Rx solution features a high 7% minoxidil in combination with tretinoin for optimal absorption. Adjuvants like cetirizine, melatonin, and caffeine may be added for anti-inflammatory support, antioxidant protection, and enhanced microcirculation. 

For patients interested in calming the scalp without actives like minoxidil, the Cetirizine Plus Rx solution delivers a proven dose of 1% cetirizine. This potent anti-inflammatory also has anti-histamine properties to support scalp health and hair growth. Caffeine and melatonin may be added for well-rounded, non-hormonal treatment. 

Like all Ulo topicals, these selections offer superior scalp penetration without irritating carriers or excipients, making them ideal for extended daily use in patients with sensitive skin or long-term combination therapy needs. 

Key Takeaway: Growth booster topicals like minoxidil, caffeine, and melatonin support follicle strength through circulation, inflammation control, and antioxidant activity, and they can be used alone or combined with DHT blockers for greater results.

Method #5: OTC Support Products for Foundational Care

Why Choose Premium OTC Products?

Quality over-the-counter support offers these foundational advantages:

Benefit:	Details:
✓ Nutritional support	Addresses deficiencies contributing to hair loss
✓ Scalp optimization	Creates an ideal environment for treatment absorption
✓ Natural ingredients	Active botanicals and peptides
✓ Complete system	Serum, supplements, shampoo, and conditioner

How Do OTC Products Work?

High-quality, non-prescription products can also help target underlying hair health factors without hormonal suppression. These include nutritional support formulas that help address common deficiencies linked to hair loss. Such formulas may contain active botanical agents with anti-inflammatory or growth-promoting effects, providing gentle systemic support.^[25]Koralewicz, M.M., Szatkowska, O.A. (2024). Topical solutions for androgenetic alopecia: evaluating efficacy and safety. Forum Dermatologicum. 10(3). 71-78. Available at: … Continue reading

Specialty hair care products, such as shampoos, conditioners, and serums, nourish and balance the scalp, providing an optimal environment for prescription medications to take hold and support overall treatment objectives. Non-prescription hair growth serums may contain botanical extracts and peptide-based therapeutics that soothe and strengthen the follicles as a complement to medical protocols. 

Ulo’s OTC Support Range

Ulo’s four non-prescription haircare products support foundational hair health in synergy with the brand’s extensive prescription range. Their Hair Growth Serum contains three proprietary peptide blends that demonstrated comparable efficacy to minoxidil in a medically supervised study. Natural active ingredients such as saw palmetto, rosemary oil, and adenosine provide gentle DHT suppression, enhanced circulation, and growth stimulation, respectively.

The nutritional Hair Growth Supplement provides extensive hair and scalp nourishment with proven ingredients like vitamin D, biotin, hydrolyzed fish collagen, and saw palmetto. Antioxidants such as chlorophyll and astaxanthin combat oxidative stress from within. 

Lastly, the Thickening Shampoo and Conditioner provide gentle daily scalp optimization with natural actives like caffeine to boost circulation, keratin to strengthen strands, and saw palmetto to suppress DHT levels. The PhD scientist-crafted formulas are free of known irritants and artificial fragrances, made instead with nourishing oils and amino acids that encourage natural hair growth and work to improve prescription treatment response.

Key Takeaway: Over-the-counter serums, supplements, and hair care products build the foundation for long-term hair preservation by supporting scalp health, addressing nutritional needs, and enhancing the effects of prescription treatments.

Why Ulo Stands Out for TRT Patients

Managing hair health during TRT requires clinical expertise to address unique hormonal challenges that generic treatments often miss. Ulo’s multidisciplinary care, personalized protocols, advanced formulations, and high-quality standards make it a leader in TRT-focused hair restoration telehealth. Below is a summary of what sets Ulo apart.

✓ Comprehensive Medical Oversight

Ulo partners exclusively with licensed and board-certified physicians to provide safe and effective care that meets the highest regulatory and safety standards. Full medical consultations and evaluations at onboarding enable Ulo’s qualified doctors to craft tailored treatment plans, while ongoing monitoring protocols establish positive outcomes.

✓ Dual Expertise in TRT and Hair Loss

Ulo operates as a leading telehealth provider with state-of-the-art services in both hair restoration and TRT, employing physicians with experience in both areas. The specialists at Ulo are uniquely qualified to address TRT-related hair loss with practical insights and actionable solutions.

✓ True Customization for TRT Needs

While most competitors tout fixed, one-size-fits-all formulations, Ulo, in contrast, carries truly customizable treatment options with adjustable doses and elective add-ons to meet individual patient needs. This is an important feature for TRT patients, who may require medications that vary from standard formulas and can be adjusted to changing responses over time.

✓ Pharmaceutical-Grade Quality Standards

Ulo ensures product quality by sourcing all medications from certified domestic pharmacies. Formulations are designed for peak bioavailability with innovative delivery systems, free of harsh additives like propylene glycol, which can be found in many hair loss products. 

✓ Transparent Pricing and Customer Support

Ulo’s fixed-rate monthly subscription pricing avoids the rising costs and hidden fees that are common among telemedicine competitors. This allows patients to budget for long-term integrated care. Subscriptions cover all essential services, including physician consultations, follow-ups, prescription deliveries, and more. The platform’s responsive customer service ensures uninterrupted treatment and full support throughout the process.

Ulo vs. Standard Hair Loss Providers

The chart below illustrates the main differences between Ulo’s expert model and standard telehealth hair loss providers, showcasing how Ulo is uniquely equipped to meet the hair restoration needs of TRT patients.

Feature	Ulo	Standard Providers
Medical Oversight	Board-certified physicians with TRT and hair loss expertise	Generic telehealth consultations
Customization	True concentration flexibility (0.005%-0.2%); adjuvant options	Fixed formulations; limited options
Formulation Quality	Pharmaceutical-grade; soft gel dutasteride for optimal bioavailability	Standard compounding; limited bioavailability
Ingredient Safety	Irritant-free; no propylene glycol or corticosteroids	Often contains propylene glycol and harsh excipients
TRT Knowledge	Dual expertise in hormone optimization and hair restoration	Hair loss focus only; limited TRT understanding
Pricing Model	Transparent flat-rate monthly subscriptions	Hidden fees and escalating costs are common
Quality Assurance	Certificates of analysis; FDA-approved pharmacy sourcing	Limited transparency; variable quality standards
Combination Options	Extensive adjuvant library (tretinoin, caffeine, melatonin, cetirizine)	Basic combinations; limited synergistic ingredients
Follow-up Care	Unlimited physician access; regular monitoring protocols	Limited follow-up; basic customer service
Treatment Coordination	Can coordinate with existing TRT protocols	No hormone therapy coordination

Safety Considerations

Hair restoration therapies, especially hormonal medications like DHT blockers, can interact with TRT and require strict medical oversight to monitor for adverse reactions. Among the different treatment methods discussed, safety profiles vary. Here is a brief overview of their safety findings. All medical concerns should ultimately be discussed with a qualified clinician.

Prescription treatments display differing safety profiles based on the delivery method, whether oral or topical. Oral DHT blockers have systemic exposure and therefore carry the risk of systemic side effects like sexual dysfunction, mood disorders, and gynecomastia; all of which require prompt medical evaluation. Oral minoxidil requires cardiovascular monitoring due to its circulatory effects.

Topical DHT blockers have limited systemic exposure and therefore milder associated side effects, often no more than minor localized scalp irritation that tends to resolve within 2-4 weeks. Regular follow-up exams are required every 3-6 months during the first year of prescribed hair loss treatment.

Over-the-counter products, such as shampoos and nutritional supplements, carry minimal risk; however, patients with allergies or sensitivities should carefully read the ingredients before use. OTC treatments can sometimes interact with medications or exacerbate underlying conditions, so it’s best to consult a healthcare professional for guidance. 

Contraindications for prescription DHT blockers include severe cardiovascular conditions, active scalp infections, and liver disease. Women who are pregnant or plan to have a future pregnancy should avoid DHT blockers due to possible birth defects. 

Consult your doctor for a complete list of all possible side effects, contraindications, and risk mitigation strategies. 

Conclusion: Battling the Hair vs. Health Trade-Off

Accelerated hair loss can be one of the most frustrating and disruptive elements of TRT, calling for sophisticated approaches that go beyond conventional hair loss treatment. TRT creates unique challenges that demand advanced intervention strategies.

Thanks to the wide-ranging methods discussed in this guide, men no longer have to choose between hair preservation and hormone optimization on TRT. With dual expertise, qualified medical oversight, and tailored formulations that meet leading quality standards, Ulo rises to meet the varied needs of TRT patients where generic providers fall short.

Don’t allow hair loss to interfere with your journey to hormonal health and restored vitality. Ulo’s scientific approach and clinical experience make them the clear choice for men seeking to maintain their hair while optimizing their hormone therapy. Consult with a licensed Ulo physician today to craft a personalized treatment plan.

Discover your unique hair preservation strategy with Ulo.

Frequently Asked Questions

Does Ulo offer testosterone replacement therapy? 

Yes, Ulo has testosterone replacement therapy offerings that include injections, topicals, and oral preparations. Like Ulo’s hair restoration services, their TRT program is medically rigorous and tailored to individual needs. Ulo’s multidisciplinary expertise gives them unique insight, enabling them to properly address both sides of the hormone equation when treating TRT-related hair loss.

Should I discuss hair loss concerns and treatment options with my doctor when starting TRT? 

Yes, all hair concerns should be discussed with your clinician before starting TRT to enable proactive treatment planning and fully informed care decisions. Your doctor will assess your health profile and treatment goals to decide whether hair loss intervention is an appropriate choice and, if so, which method is best for you. 

Which hair loss treatments require a prescription? 

Prescriptions are required for DHT blockers like dutasteride and finasteride, growth stimulators like minoxidil, and some customized topicals. All require proper diagnostic and follow-up care protocols that meet clinical safety standards. Options that don’t require a prescription include over-the-counter nutritional supplements, serums, shampoos, and conditioners with unrestricted active ingredients like botanical extracts and peptides.   

Can I combine hair loss treatment methods? 

Yes, some hair loss treatments can be combined for synergistic effects. Popular combinations include minoxidil with DHT blockers (dutasteride or finasteride), alongside nutritional support. Treatments should only be combined under close medical supervision to avoid harmful interactions.

When do most hair loss treatments show results? 

Although results differ depending on the patient and treatment type, most users experience initial effects within the first 3-6 months and more substantial benefits over 6-18 months. Consistent daily administration is required to successfully achieve and maintain hair loss treatment benefits. 

What are common hair loss treatment side effects? 

Potential side effects vary based on the type of treatment and are usually controllable with the right medical care. Topical treatments can produce mild and temporary irritation at the application site.  Although rare, oral DHT-blocking medications can lead to systemic side effects like sexual dysfunction and mood disturbances requiring immediate medical attention. Thoroughly discuss all potential side effects and suitable monitoring protocols with your provider.

How much do Ulo’s hair loss treatments typically cost? 

Ulo’s price points vary by treatment type and level of customization. Pricing reflects flat-rate monthly subscription fees that not only cover the cost of the medication but also include essential telehealth services like doctor consultations, follow-ups, and prescription deliveries. Their prescription oral treatments range from $24 to $65 per month, while topicals range from about $49 to $94 per month. OTC support products start at $29 per month. 

What should I expect during my first consultation with Ulo? 

The Ulo onboarding process starts with a thorough medical intake form that covers your health profile, treatment goals, and current medications. You will be partnered with one of Ulo’s licensed physicians, who, after reviewing your information, will collaborate with you to design a treatment plan tailored to your specific needs. During the initial consultation, your doctor will thoroughly discuss treatment options, realistic expectations, safety, and follow-up protocols to guarantee safe and effective care.

Millions worldwide experience hair loss, with androgenic alopecia (AGA) as the leading cause. Also known as male- or female-pattern hair loss, AGA becomes more prevalent with age. It affects a majority of men over the age of 50 and a substantial number of postmenopausal women. Hair thinning and balding due to AGA is not just a cosmetic concern but can significantly detract from self-esteem and overall quality of life. 

Among popular hair restoration treatments, topical dutasteride is a breakthrough solution to the serious side effects and plateaued results many experience. This potent DHT blocker offers more targeted therapeutic benefits with minimal systemic exposure and reduced risk. However, not all topical dutasteride products meet quality standards, so specialized guidance is key to selecting the right formula. 

The PhD-directed board of experts at Perfect Hair Health draws from the latest clinical data and verified customer feedback to deliver this comprehensive guide to the best topical dutasteride products available in 2025. Through our research collaboration with leading innovators in the field, including our partnership with Ulo, we provide unique insights into the most advanced hair restoration protocols.

Read on for our detailed analysis and evidence-based product recommendations. 

Interested in Topical Dutasteride?

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*Only available in the U.S. Prescriptions not guaranteed. Restrictions apply. Off-label products are not endorsed by the FDA.

Quick View: 8 Best Topical Dutasteride Products

Here’s a brief comparison of our most highly recommended topical dutasteride products. Continue reading for in-depth reviews. 

Product	Price	Dutasteride %	Delivery Method	Key Feature
Ulo	$84+/month	0.02%-0.2%	Solution	PhD-developed extensive customization
XYON Health	$129+/month	2%	Gel	Patented controlled-release technology
Strut Health	$69/month	Up to 0.1%	Gel	Alcohol-free and customizable
Blends	~$45/month (90-day supply)	0.3%	Gel	Proprietary hydrating formula
Happy Head	$59-89+/month	Up to 0.3%	Solution	Potency and customization
Maximus	$54.99	0.1%	Gel	Customizability, including the addition of antihistamines
Miiskin	$30-59 + Rx cost	Variable, custom	Solution	No subscription required
Musely	$33/month	0.3%	Solution	Lowest cost option

Science and Benefits of Topical Dutasteride

To begin, we will briefly explore the scientific background of topical dutasteride, including how it works to treat AGA and the distinct benefits of topical preparations.

Mechanism of Action 

Topical dutasteride is valued as a breakthrough treatment for AGA due to its powerful and targeted effects on the molecular levels of hair loss. The root cause of AGA is the testosterone-derived hormone dihydrotestosterone (DHT), which adheres to hair follicles and leads to follicular degeneration and hair loss over time. Dutasteride is classified as a DHT blocker, reducing DHT levels on the scalp to combat hair loss.^[1]R. Cuevas-Díaz Durán., Martinez-Ledesma, E., Garcia-Garcia, M., Gauzin, D.B., Sarro-Ramirez, A., Gonzalez-Carrillo, C., Rodriguez-Sardin, D., Fuentes, A., Cardenas-Lopez, A. (2024) The Biology and … Continue reading,^[2]Dhurat, R., Sharma, A., Rudnicka, L., Kroumpouzos, G., Kassir, M., Galadari, H., Wollina, U., Lotti, T., Golubović, M., Binic, I., Grabbe, S., & Goldust, M. (2020). 5‐Alpha reductase … Continue reading

Among DHT-blocking treatments, dutasteride is considered the most potent due to its dual enzyme activity. Testosterone is converted into DHT through two forms of 5α-reductase enzymes: Type I is located in the skin and sebaceous glands, and Type II is in the hair follicles. Finasteride inhibits only Type II for about 70% DHT reduction, while dutasteride inhibits both types to elicit greater DHT suppression (up to 93% in the skin and 99% in the follicles).^[3]Arif, T., Dorjay, K., Adil, M., & Sami, M. (2017). Dutasteride in Androgenetic Alopecia: An Update.. Current clinical pharmacology, 12 1, 31-35. Available at: … Continue reading

Dutasteride’s powerful DHT inhibition leads to greater therapeutic outcomes in hair restoration. Clinical findings indicate dutasteride’s superior effects on hair count and mass in comparison to finasteride in terms of both quantitative and temporal metrics. While finasteride’s benefits tend to plateau after about 12 months of treatment, dutasteride demonstrates continued improvements up to 12 months and beyond.^[4]Harcha, W., Martínez, J., Tsai, T., Katsuoka, K., Kawashima, M., Tsuboi, R., Barnes, A., Ferron-Brady, G., & Chetty, D. (2014). A randomized, active- and placebo-controlled study of the efficacy … Continue reading

Topical vs. Oral Advantages 

Studies show that topical dutasteride is a safer option than oral with comparable and often better treatment outcomes. When applied locally to the scalp, dutasteride delivers targeted treatment with limited systemic exposure and a reduced risk of serious side effects. If present, adverse reactions to topical dutasteride tend to be transient and mild, in contrast to oral dutasteride’s potential systemic side effects like sexual dysfunction and mood disorders.^[5]Obeid, M., Fattah, N., Elfangary, M., & Husseni, R. (2024). Comparison between Topical Minoxidil 5% Alone versus Combined with Dutasteride (Topical 0.02% through Microneedling or Oral 0.5 mg) in … Continue reading,^[6]Ding, Y., Wang, C., Bi, L., Du, Y., Lu, C., Zhao, M., & Fan, W. (2024). Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review. Dermatology, 240, 833 – 843. Available at: … Continue reading 

This and other clinically proposed advantages of topical dutasteride are briefly summarized as follows: 

• Safe and Targeted Treatment: Oral dutasteride has systemic exposure through the bloodstream and therefore runs the risk of more serious side effects. Meanwhile, topical treatment targets only the scalp, lowering the risk of severe adverse reactions. Minor irritation at the site of application may occur and tends to resolve quickly. 
• Flexible Dosing: Topical formulations offer greater dose flexibility through modified concentrations, in contrast to the usually fixed doses of oral preparations. Common topical offerings range from a maintenance dose of 0.02% dutasteride to advanced therapies of 2%, allowing dose-dependent customization. 
• Increased Personalization: Topicals can easily integrate synergistic treatments like vasodilators (minoxidil), absorption enhancers (tretinoin), and anti-inflammatories (melatonin) for combination therapies that outperform dutasteride alone. These add-ons are prescribed based on patients’ individual needs and treatment goals.

Plus, patients have a choice of different delivery methods (e.g., sprays, gels, solutions), which can offer greater convenience and adherence.

• Long-term Outlook: Topical use is considered safer for long-term treatment due to its reduced systemic effects. Because hair restoration treatments’ benefits build with time, their suitability for prolonged use is paramount. 

Combined, these factors locate topical dutasteride as a more effective and flexible hair restoration intervention with a greater safety profile than its oral counterpart.^[7]Obeid, M., Fattah, N., Elfangary, M., & Husseni, R. (2024). Comparison between Topical Minoxidil 5% Alone versus Combined with Dutasteride (Topical 0.02% through Microneedling or Oral 0.5 mg) in … Continue reading,^[8]Ding, Y., Wang, C., Bi, L., Du, Y., Lu, C., Zhao, M., & Fan, W. (2024). Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review. Dermatology, 240, 833 – 843. Available at: … Continue reading,^[9]Radhakrishnan, P., Mariyappan, G., Karthi, J., & Jaisumi, K. (2024). Formulating, Optimizing and Evaluation of Dutasteride Loaded Insitu-Emulgel for Androgenetic Alopecia. International Journal … Continue reading

Choosing the Best: What We Looked For

To help navigate the topical dutasteride market, we developed these quality benchmarks grounded in clinical expertise, scientific evidence, and patient feedback.

Clinical Efficacy

Quality dutasteride products demonstrate notable DHT reduction and improved hair growth within 3-6 months, with these effects continuing over 12 months or longer. The products recommended in this article were assessed based on documented DHT reductions, verified patient feedback, and peer-reviewed studies.

Safety Profile and Medical Oversight

Given the prescription status of topical dutasteride, we verified each telehealth provider’s legitimacy in terms of physician supervision, adherence to legal requirements, and adherence to sound safety protocols. These include proper diagnostic procedures before prescribing, as well as close follow-up care to monitor for side effects and adjust the treatment as needed for optimal outcomes. Trustworthy providers exclusively partner with licensed physicians specialized in hair restoration. 

When it comes to quality assurance, suppliers must partner only with authorized domestic pharmacies to source their compounded medications. Complete ingredient transparency and labeling of allergens establishes acceptable safety profiles.

Personalization Options

Varied patient needs call for customizable treatments that exceed standard one-size-fits-all protocols. Outstanding brands provide a personalized approach through extensive customization options, including variable concentrations, adjuvant blends (e.g., minoxidil), and various delivery formats (e.g., solutions and controlled-release gels). These tailored therapies are physician-crafted to safely elicit the best results. 

User Experience

Prolonged, uninterrupted treatment is necessary to achieve positive results, highlighting the importance of user comfort and satisfaction. Practical considerations, such as application convenience, precise instructions, manageable dose routines, and excellent customer support, all influence treatment adherence.

Cost Transparency

Because treatment sustainability also depends on affordability, we also examined billing models and price transparency. Premium suppliers have honest and reasonable pricing that covers primary treatment costs (prescriptions, consultations, deliveries, and monitoring), free of hidden fees that are common among telehealth providers. 

Selecting Your Ideal Treatment

Begin by assessing your hair loss level and treatment objectives, determining whether moderate maintenance or intensive regrowth protocols are needed. Further considerations include application method preferences (gels, solutions, sprays, etc.), helpful adjuvants, and skin sensitivities. Budgetary limitations and your required level of physician involvement also come into play. 

With these factors in mind, let’s dive into the following product reviews that highlight distinct approaches.

Our Top 8 Topical Dutasteride Products

#1: Ulo Dutasteride + Minoxidil Plus Rx

Pros:	Cons:
✓ PhD-scientist developed with thorough customization	✗ USA-only service for prescription treatments
✓ Customizable concentrations with adjuvant ingredients
✓ Board-certified physician oversight, monitoring, and tailored treatment protocols
✓ Verified quality and safety
✓ Full price transparency and free shipping

The top position goes to Ulo, a leader in clinical rigor and precision hair loss medicine. Known for their highly individualized treatments, cutting-edge protocols, and PhD oversight, Ulo’s offerings are among the most comprehensive and patient-centered available. Their dual topical dutasteride solution with minoxidil delivers potent DHT suppression and new growth stimulation, proven to be more effective than either therapy alone. 

Ulo’s topical systems feature customization across the spectrum, from dutasteride concentration (0.02% for lighter therapy to 0.2% for more aggressive intervention) to adjuvants like absorption enhancers, antioxidants, and vasodilators. Premium services include licensed dermatologist consultations, tailored treatment plans, and continued medical oversight, with a starting monthly subscription price of $84 and no added fees. 

All Ulo safety and medication sourcing practices adhere to the highest regulatory standards, including partnerships with certified domestic pharmacies and strict follow-up protocols. Full ingredient transparency and irritant-free formulations establish excellent safety profiles. Patients enjoy free prescription deliveries and responsive support through Ulo’s sleek telehealth platform.

Our Verdict: Ulo’s advanced dual formula harnesses the power of customized topical dutasteride to deliver the gold standard of hair loss therapy. With PhD-developed formulas, genuine customization, and complete medical oversight, this platform offers proven benefits through a transparent monthly subscription that starts at $84. Their dedication to upholding the highest standards of safe and effective care positions Ulo as the best choice for your hair restoration needs. 

#2 XYON Topical Dutasteride

Pros:	Cons:
✓ Proprietary SiloxysSystem™ Gel for timed release	✗ Premium pricing at $129/month
✓ Highest concentration (2% dutasteride) for aggressive protocols	✗ Limited customization options
✓ Physician oversight	✗ Not recommended for sensitive skin
✓ Service area includes the US and Canada

XYON stands out for its innovative, technology-driven approach, exemplified by its proprietary SiloxysSystem Gel delivery base, which contains delayed-release topical dutasteride at a high concentration of 2%. This controlled-release method allows for a higher dutasteride concentration and more targeted treatment, protecting against systemic exposure and potentially serious side effects. 

While this treatment is a strong option for advanced hair loss cases due to its potency, XYON emphasizes its advanced and proven delivery method over treatment customization features. Monotherapy involves a fixed dose of 2% dutasteride, which may be too strong for some patients. Excipients include ingredients like silicone that are not recommended for sensitive skin. 

XYON’s premium price point reflects not only its forward-looking strategy but also its high medical standards, as the platform offers qualified physician support throughout the process. 

Our Verdict: XYON’s topical dutasteride formulation delivers maximum treatment with minimal systemic risk through its unique delayed-release carrier gel. It is recommended for advanced hair loss patients who can tolerate higher doses and potential irritants, particularly those who don’t mind paying a premium for its advanced technology development. 

#3: Strut Health Topical Dutasteride Gel

Pros:	Cons:
✓ Good value at $69/month with full customization	✗ Lower maximum dutasteride concentration (0.1%)
✓ Alcohol-free, preservative-free options available	✗ Moderate doses may be insufficient for advanced hair loss cases
✓ Extensive customization of adjuvant ingredients	✗ Occasional gaps in customer service are cited
✓ Licensed medical oversight with hair loss specialization	✗ Service area excludes Arkansas

Strut Health is a solid mid-tier option that balances accessible pricing with medically guided customization, emphasizing cost-effectiveness over potency. The preservative- and alcohol-free dutasteride gel contains a moderate 0.1% dutasteride, with tailored add-on options including minoxidil, biotin, and tretinoin at varying concentrations. Capped at such a middling dose, this gentle gel formula is best for mild to moderate hair loss patients with sensitive or dry skin.

Fluocinolone, a corticosteroid, is also available as an adjuvant. While leading providers like Ulo avoid such ingredients due to potential safety concerns, Strut provides appropriate safety disclaimers and maintains an overall emphasis on ingredient transparency, backed by medical oversight.

Strut’s subscription fee of $69 per month for topical dutasteride treatment is a competitive offering, covering consultations, follow-ups, and prescription shipping. Patients cite flexible cancellation policies and rapid home deliveries as notable benefits. We detected some mixed reviews regarding delayed customer service responses and logistical issues.

Our Verdict: Strut Health offers a compelling value proposition with its topical dutasteride gel, priced at only $69 per month, and features that rival those of more expensive providers. The gentle formula with a limited 0.1% dutasteride concentration suits patients with moderate treatment needs who are seeking a budget-friendly option with flexible add-ons and legitimate medical oversight. 

#4: Blends Growth PRO Topical

Pros:	Cons:
✓ Doctor-founded with hair restoration specialization	✗ 90-day supply requirement may not suit all patients
✓ Competitive pricing at ~$45/month (90-day supply)	✗ Fixed formula despite “personalized” marketing claims
✓ Preservative-free, alcohol-free formula with 5 active ingredients	✗ Includes latanoprost with limited long-term safety data for scalp use
✓ 0.3% dutasteride and 7.5% minoxidil offer powerful DHT inhibition	✗ Lacks true customization compared to leading competitors
✓ Proprietary hydrating gel base with advanced formulation

Blends is a physician-founded company with a heavy focus on cutting-edge manufacturing methods and sophisticated formulations. Their small but specialized catalog includes this topical dutasteride treatment made with a proprietary gel base for timed medication release and scalp hydration. Free of alcohol and preservatives, the concentrated 0.3% dutasteride and 7.5% minoxidil formula offers powerful therapeutic effects.

Although Blends asserts the “personalized” and “customized” nature of its products, its Growth Pro Topical gel is actually a comprehensive fixed formula with three adjuvant ingredients in addition to dutasteride and minoxidil: tretinoin, latanoprost, and ketoconazole. Competitively priced at about $45/month (sold in 90-day batches), this offering stands out for its full ingredient transparency and high concentrations suited to aggressive treatment protocols.

However, the use of latanoprost poses concerns due to the lack of long-term studies confirming its safety and efficacy as a topical hair loss treatment. Despite marketing claims of customized protocols, Blends does not allow formulation adjustments to this fixed gel product. Although the monthly cost is lower than that of most leading brands of comparable quality, the minimum purchase requirement of a 90-day supply (~$135) may not suit all patients. 

Our Verdict: This physician-crafted gel formula from Blends is competitively priced, featuring high concentrations of synergistic ingredients for advanced hair loss treatment. Its positioning as a mid-level selection rather than a top choice is due to its false personalization claims and unproven add-on ingredient. 

#5: Happy Head Topical Rx Dutasteride & Minoxidil

Pros:	Cons:
✓ Dermatologist oversight with ongoing support	✗ Limited dutasteride concentration options
✓ 0.3% dutasteride and 8% minoxidil  formula with customizable add-ons, including ketoconazole	✗ Pricing increases after the initial months and can reach ~$109
✓ Established brand with a 6-month money-back guarantee	✗  Some formulations contain potential irritants
✓ User-friendly platform and free consultation	✗ Shipping and customer service inconsistencies

Happy Head represents a dependable option for targeted hair restoration, recognized for its dermatologist-backed and customizable treatments. This hybrid dutasteride-minoxidil solution offers a strong dose of 0.3% dutasteride with up to 8% minoxidil for effective DHT reduction. Elective adjuvants include retinoic acid and hydrocortisone. Anti-dandruff agent ketoconazole can be added for an additional fee. 

While some clinicians warn against the use of topical corticosteroids like hydrocortisone, Happy Head seems to follow established medical safety protocols with appropriate disclaimers. Inactive ingredients like alcohol and propylene glycol can irritate and should be approached with caution. Highly concentrated DHT blockers with harsh excipients require close medical oversight, and patients with sensitive skin may want to seek other options. 

Although transparent about costs, Happy Head’s variable pricing can grow quickly with treatment duration and formulation. Their topical dutasteride solution starts at $59 per month and shifts to $89 after the first six months. The anti-dandruff adjuvant can be added for $20, bringing the total to $109 per month, which exceeds the cost of some comparable providers. Mixed patient reviews cite issues with deliveries and logistical support.

Our Verdict: This combination treatment from Happy Head is a solid choice for patients in need of more aggressive treatment and concentrated formulas. Continued dermatologist oversight, personalization options, and potent formulations can help patients whose results may have stalled on other treatments. However, highly active ingredients and variable pricing may deter those seeking gentler therapies and fixed costs.

#6 Maximus Dutasteride+ Gel

Pros:	Cons:
✓ High level of personalization with physician-driven telehealth oversight	✗ Limited long-term safety data for some ingredient combinations
✓ Competitive monthly pricing	✗ Availability restricted to the U.S.
✓ Physician-guided treatment plans and ongoing clinical support	✗ No subscription flexibility (all via 90-day supply)
✓ Proprietary gel base designed for scalp absorption and minimal mess
✓ Evidence-informed protocols supported by board-certified physicians

 

Maximus Tribe’s Max-Absorb Gel is a highly customizable, prescription-only hair loss solution leveraging physician-driven telehealth and evidence-based formulation. At $54.99 for a 90-day supply, it offers a lot of value for those looking for efficacy and clinical support. The core formulation includes dutasteride (0.1%) with optional minoxidil, tretinoin, and fexofenadine, delivered in a proprietary gel base that is designed to minimize mess and maximize scalp coverage. 

Maximus prioritizes convenience and targeted care: onboarding and ongoing support are managed by board-certified doctors, and the medication is shipped directly to the patient for easy home application. While ingredient customization and clinical guidance are strengths, choices remain limited in comparison to other telehealth options (like Ulo). 

Our Verdict: Maximus offers a well-priced topical dutasteride gel that balances multi-ingredient efficacy with convenient home use and physician oversight. 

#7: Miiskin Dutasteride + Minoxidil

Pros:	Cons:
✓ Direct board-certified dermatologist consultations	✗ Total cost varies with third-party pharmacy fees
✓ Custom-compounded formulations with up to 3 active ingredients	✗ Basic compounding without advanced delivery systems
✓ No automatic subscriptions—pay per order	✗ Less specialized in hair loss compared to dedicated platforms
✓ Legitimate medical oversight with prescription flexibility
✓ Serves both the USA and Mexico

Miiskin differs from the subscription-based providers on this list, as it facilitates direct medical consultations between patients and qualified dermatologists. The pay-as-you-go model allows legitimate medical access without subscription requirements. Miiskin charges $59 for initial consultations and $30 for returning visits. Medication fees vary and are charged separately at the pharmacy where the medication is filled.

While the dermatologist-direct platform increases access to qualified care and prescription hair loss treatments, its simple compounded formulas lack the customization and specialization of leading brands. Ingredient disclosure is limited beyond general mentions of three-active-ingredient formulations and the listing of a combination of dutasteride and minoxidil therapy.

The model does not permit total cost calculation until third-party pharmacy checkout, separate from Miiskin’s billing process, which only covers prescribing dermatologist consultation fees.

Our Verdict: Although Miiskin offers medical legitimacy, the dermatology consultation platform lacks the treatment specialization and transparency of top dutasteride therapy sources. It may be a valuable tool for patients with hair loss to connect with qualified providers and access basic compounded formulas. 

#8 Musely The Hair Topical Solution – Classic

Pros:	Cons:
✓ Lowest cost option at $33/month	✗ Minimal medical oversight compared to competitors
✓ 0.3% dutasteride concentration in a customizable formula	✗ Limited customization options
✓ Aesthetic medicine platform with dermatologist involvement	✗ Medical rigor lacking
✓ Multi-ingredient formulations	✗ Less specialized hair loss expertise
	✗ Some ingredients are not recommended for sensitive skin

Musely’s topical dutasteride solution occupies the final slot on our list as the lowest-priced option at just $33 per month (plus a one-time $20 consultation fee at onboarding). The lower price point reflects less extensive offerings that are well-suited for patients who prefer a more self-directed approach. This tailored prescription formulation combines up to 0.3% dutasteride and 8% minoxidil with optional add-ons of ketoconazole to fight dandruff and hydrocortisone to reduce inflammation. 

It is less customizable than other options, characteristic of Musely’s simplified strategy. Excipients like propylene glycol and alcohol may deter ingredient-conscious consumers due to irritant potential. While such potent formulas and highly active ingredients offer more powerful treatment, they also carry a greater risk of adverse reactions and call for qualified medical supervision. 

However, unlike premium providers, Musely is not known for close medical oversight. In fact, the aesthetic medicine platform has a markedly superficial onboarding and assessment process that falls short of the thorough medical evaluations offered by top providers. Although clinicians are involved in the platform, follow-up care and specialized hair restoration knowledge are lacking, according to customer reviews. 

Our Verdict: Musely is included as a purely budget-friendly option for cost-conscious patients who understand the importance of self-monitoring and supplement with appropriate medical consultation. 

Bottom Line on Buying Topical Dutasteride Online

According to our thorough analysis, Ulo is the best choice for topical dutasteride therapy in 2025. This platform stands out for its rigorous scientific foundation, highly tailored treatments, and commitment to close medical oversight, outperforming the fixed protocols and misleading marketing claims of its peers. 

 

Rather than standardized approaches, Ulo’s PhD-designed therapies with built-in customization features meet the individual needs of each patient, representing the pinnacle of evidence-based precision care in the rapidly evolving field of hair restoration medicine.

Expectations and Timeline

Clinical findings support the following timeline of expected treatment outcomes in topical dutasteride therapy. Familiarity with these will ground your therapy in a realistic outlook, encouraging patience and prolonged adherence.^[10]Obeid, M., Fattah, N., Elfangary, M., & Husseni, R. (2024). Comparison between Topical Minoxidil 5% Alone versus Combined with Dutasteride (Topical 0.02% through Microneedling or Oral 0.5 mg) in … Continue reading,^[11]Ding, Y., Wang, C., Bi, L., Du, Y., Lu, C., Zhao, M., & Fan, W. (2024). Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review. Dermatology, 240, 833 – 843. Available at: … Continue reading,^[12]Radhakrishnan, P., Mariyappan, G., Karthi, J., & Jaisumi, K. (2024). Formulating, Optimizing and Evaluation of Dutasteride Loaded Insitu-Emulgel for Androgenetic Alopecia. International Journal … Continue reading

• Early Stage (Months 1-3): Within days of beginning treatment, scalp DHT levels start to decline, although cosmetic improvements take longer to show as existing hair cycles complete. Some patients may experience temporary hair shedding in the first 2-8 weeks, which is considered a positive sign that the treatment is working by triggering new growth cycles. 

• Emergence Stage (Months 3-6): After about 3 months of continued therapy, subtle visible improvements typically begin to emerge. Existing strands become thicker, and previously inert hair follicles are reactivated to produce new shafts for measurable increases in hair count metrics.

• Maximization Stage (Months 6-18): This phase sees the most considerable improvements, as hair count and diameter continue to increase for a thicker, healthier appearance. The majority of patients reach optimal results within a year. 

• Maintenance Stage (Long-Term): After reaching peak outcomes, continuous daily application is necessary to sustain benefits. Studies show that indefinite treatment can maintain positive results, although occasional adjustments may be needed over time to account for typical signs of aging.

Risk Profile and Safety

Topical dutasteride is considered a safe hair loss intervention, particularly when weighed against oral formulas that can carry substantial risk due to systemic exposure. Nonetheless, informed risk assessment and familiarity with safety protocols are recommended before beginning any new treatment. Here is a brief overview of medical data on the safety and side effects of topical dutasteride.^[13]Ding, Y., Wang, C., Bi, L., Du, Y., Lu, C., Zhao, M., & Fan, W. (2024). Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review. Dermatology, 240, 833 – 843. Available at: … Continue reading

Common Side Effects

Adverse patient reactions to topical dutasteride are rare and typically limited to mild, localized scalp irritation that resolves in 2-4 weeks, occurring in only about 5-10% of new users. Depending on individual sensitivities and irritating formulation additives like alcohol, scalp dryness, flaking, and contact dermatitis are possible, though the latter is less common. Mild systemic side effects are extremely rare, documented in under 2% of patients. 

Serious Considerations

Also rare are severe allergic reactions and pronounced systemic side effects, which can include sexual dysfunction, mood disorders, and gynecomastia. These all warrant prompt medical intervention. Topical dutasteride is not recommended in patients with active scalp infections and hormonal disorders.

Topical dutasteride is strongly contraindicated in pregnant or nursing women and in those planning future pregnancies due to the risk of birth defects. Patients with known hypersensitivity to DHT blockers should also avoid use.

Safety and optimal treatment outcomes depend on regular medical follow-up evaluations, typically at three-month intervals in the first year. This enables early identification of problems and treatment response evaluation.

Conclusion: Best Topical Dustaride Products

Cutting-edge topical dutasteride formulations bridge the gap between pharmacological precision and patient satisfaction in hair restoration therapy. Available products represent a spectrum of targeted, proven treatments that are considered safer and more customizable than previous-generation modalities.

Our thorough review of the evolving market identified clear leaders, with Ulo setting itself apart as an exemplary provider of topical dutasteride. Its scientifically optimized protocols are tailored to meet the individual needs of each patient, with qualified medical supervision to ensure a safe and transformative treatment experience.

As hair restoration technology advances, leading topical dutasteride formulations, such as Ulo’s, are at the forefront, empowering users with convenient and clinically proven solutions that not only enhance appearance but also improve quality of life.

Explore Ulo’s advanced topical dutasteride treatments today.

Frequently Asked Questions 

Do I need a prescription for topical dutasteride? Yes, topical dutasteride is a prescription-only treatment in the United States. This ensures proper candidate screening and legitimate medical supervision throughout treatment.

When can I expect results? Initial DHT suppression on the scalp occurs within the first few days, but visible changes in hair growth typically emerge within 3-4 months.  Benefits generally reach their peak after 12-18 months of consistent application.

How do I apply topical dutasteride? Use the product applicator to deposit the treatment directly onto clean, dry scalp areas where you are experiencing hair loss. Allow it to absorb fully before using other hair products. Following application, avoid wetting the hair for several hours and wash your hands thoroughly.

Can I combine topical dutasteride with other treatments? Yes, the benefits of topical dutasteride can be enhanced through combination therapies, such as minoxidil. Consult your prescribing doctor to learn about safe and effective hybrid treatments.

What will happen if I stop treatment? When treatment is halted, scalp DHT levels gradually return to starting levels, which typically leads to resumed hair loss after several months.

How much does topical dutasteride cost? Pricing varies from about $30 to $135+ for a monthly supply, depending on concentration, formulation, brand, and telehealth services included. Leading brands provide comprehensive medical oversight and customization, offering transparent and flat-rate monthly subscription fees. 

Finding the right hair loss treatment can feel overwhelming, and expert guidance is essential to identify the best formula for your needs. The PhD-led team at Perfect Hair Health leverages emerging research and close collaborations with top innovators to provide readers with the most accurate and actionable reviews of hair restoration offerings. Topical finasteride is one of the most sought-after treatments on the market, boasting clinical support, targeted results, and easy application. 

This comprehensive guide to the top-rated topical finasteride products is based on extensive research, expert recommendations, and the latest consumer feedback. Whether you’re just beginning your hair health journey or searching for better hair loss solutions, this article provides valuable information on safe and effective treatment options. Our recent partnership with Ulo enhances this guide with privileged insights on clinical findings and state-of-the-art protocols.  

Read on for specialized guidance, insightful reviews, and proven recommendations of topical finasteride preparations from today’s leading brands. 

Interested in Topical Finasteride?

Low-dose & full-strength finasteride available, if prescribed*

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*Only available in the U.S. Prescriptions not guaranteed. Restrictions apply. Off-label products are not endorsed by the FDA.

Quick Look: 5 Best Topical Finasteride Products

Here’s a side-by-side comparison of our top recommended topical finasteride treatments. Read on for more details on each of these excellent products. 

Product	Price	Finasteride %	Customization	Application
Ulo	$64+/month	0.005% – 0.2%	High	Solution
Strut Health	$59	0.1-0.25%	Medium	Solution/Gel
Happy Head	$59-99/month	0.3%	Medium	Liposomal Gel
Roman	$50/month	0.3%	Low	Spray
Hims	$35+/month	0.3%	Low	Spray

Topical Finasteride: What It Is & Why It’s Better 

First, we will briefly explore the science behind topical finasteride, including its mechanism of action in treating hair loss and the advantages of topical formulations. 

What Is Topical Finasteride?

Topical finasteride is a clinically proven treatment for androgenic alopecia (AGA), a type of hair loss that affects more than 50% of men by the age of 50.^[1]Jang, W.S., Son, I.P., Yeo, I.K., Park, K.Y., Li, K., Kim, B.J., Seo, S.J., Kim, M.N., Hong, C.K. (2013). The Annual Changes of Clinical Manifestation of Androgenetic Alopecia Clinic in Korean Males … Continue reading AGA is caused by dihydrotestosterone (DHT), a testosterone-derived hormone that damages hair follicles, causing them to shrink and produce thinner hair. Finasteride reduces DHT levels by inhibiting the enzyme 5-alpha-reductase, protecting the hair follicles to stop hair loss and encourage new growth.^[2]Duran, R, C-D., Martinez-Ledesma, E., Garcia-Garcia, M., Gauzin, D.B., Sarro-Ramirez, A., Gonzalez-Carillo, C., Rodriguez-Sardin, D., Fuentes, A., Cardenas-Lopez. (2024). The Biology and Genomics of … Continue reading 

While orally administered finasteride has been in use since 1997, topical formulations are a relatively new development. When applied to the scalp, finasteride provides targeted treatment with a reduced risk of systemic side effects associated with oral preparations. Topical finasteride is shown to reduce DHT levels on the scalp for greater hair count and density with comparable effectiveness to oral finasteride.^[3]Lee, S.W, Juhasz, M., Mobasher, P., Ekelem, C., Mesinkovska, N.A. (2018).  A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. Journal of Drugs in … Continue reading

Numerous studies confirm that topical finasteride slows and reverses hair loss by boosting hair thickness, density, and growth cycles. These results are enhanced when combined with other topical treatments like minoxidil. Due to minimal systemic absorption and attendant side effects, topical formulas are considered a safer choice for prolonged use. Overall, topical finasteride is prized among clinicians and patients as a safe, effective, and convenient solution to pattern hair loss.^[4]Lee, S.W, Juhasz, M., Mobasher, P., Ekelem, C., Mesinkovska, N.A. (2018).  A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. Journal of Drugs in … Continue reading,^[5]Piraccini, B.M., Blume-Peytavi, U., Scarci, F., Jansat, J.M., Falques, M., Otero, R., Tamarit, M.L., Galvan, J., Tebbs, V., Massana, E. (2021). Efficacy and safety of topical finasteride spray … Continue reading

Why Choose Topical Over Oral?

Because topical finasteride is applied directly to the scalp, it offers localized therapy and avoids the side effects associated with oral finasteride’s systemic exposure. Here is a brief overview of this and other primary advantages of topical formulas:

• Better Safety Profile: Oral finasteride is absorbed into the bloodstream and can have global side effects like sexual dysfunction, hormone disruption, and mood swings. In contrast, topical formulas target the scalp directly and minimally affect plasma levels. Topicals are consistently shown to have fewer systemic side effects. If present, side effects tend to be mild and temporary, such as scalp irritation.

• Individualized Dosing: While the oral finasteride dose is a standardized 1 mg, topical formulas enable tailored dosages and greater precision through potency titration. This is especially important given the dose-dependent outcomes of finasteride treatment. The finasteride concentration in topicals can range from a maintenance dose of 0.005% to a more aggressive protocol of 2.5%.

• Greater Customization: Topical formulas often combine other proven treatments, such as tretinoin, minoxidil, and caffeine. Studies demonstrate that finasteride-minoxidil combinations deliver superior results compared to single-agent treatments. Plus, the range of available delivery methods (e.g., solutions, sprays, gels) can improve convenience, satisfaction, and adherence. 

• Long-Term Use: With a better safety profile and lower systemic impact, topical finasteride is more suitable for prolonged use, which is often necessary to maintain the benefits of hair loss treatment. 

In short, research data indicate that topical finasteride yields comparable results with a more favorable safety profile than oral finasteride, making it a better option for long-term treatment. Further benefits of topical formulations include greater dose precision, synergistic adjuvants like minoxidil, and a range of delivery methods to support compliance.^[6]Lee, S.W, Juhasz, M., Mobasher, P., Ekelem, C., Mesinkovska, N.A. (2018).  A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. Journal of Drugs in … Continue reading,^[7]Piraccini, B.M., Blume-Peytavi, U., Scarci, F., Jansat, J.M., Falques, M., Otero, R., Tamarit, M.L., Galvan, J., Tebbs, V., Massana, E. (2021). Efficacy and safety of topical finasteride spray … Continue reading

Evaluation Criteria: What Makes the Best?

When selecting the best topical finasteride products, we adhered to the following evaluation criteria, which are thoroughly supported by clinical findings and customer feedback.^[8]Piraccini, B.M., Blume-Peytavi, U., Scarci, F., Jansat, J.M., Falques, M., Otero, R., Tamarit, M.L., Galvan, J., Tebbs, V., Massana, E. (2021). Efficacy and safety of topical finasteride spray … Continue reading,^[9]Suchonwanit, P., Iamsumang, W., Leerunyakul, K. (2020). Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature. Journal … Continue reading

✓ Effectiveness

We assessed scientific data, DHT decrease rates, and real-world testimonies of hair count increases. The top products deliver measurable results in 3-6 months with continuous improvements in hair density throughout the first year and beyond.

✓ Safety

Because finasteride is a prescription-only treatment, we verified that providers adhere to all safety regulations, including proper prescribing and monitoring protocols. Leading suppliers also provide full ingredient transparency to help assess potential side effects.

✓ Customization

Premium brands offer treatment customization options tailored to patients’ needs and preferences, maximizing outcomes beyond those achieved with traditional, standardized approaches. These include concentration adjustments, synergistic add-on ingredients such as minoxidil, and various delivery methods. 

✓ Convenience

Successful treatment outcomes depend on long-term compliance and a positive user experience. Factors such as ease of application, clear instructions, manageable dose frequency, and responsive support help ensure uninterrupted treatment.

✓ Value

The best providers balance superior quality with transparent and affordable pricing models that cover doctor consultations, prescriptions, and follow-up care. These are especially important concerns in the telehealth landscape, where many subpar platforms employ opaque billing practices to stack on hidden fees and unexpected charges.  

How to Choose the Right Product for Your Needs 

When choosing the product that best meets your hair loss treatment needs, consider the extent of your hair loss and treatment aims, such as basic upkeep or intensive restoration. Also account for your preferred delivery method (i.e., gel, solution, or spray), desired add-ons, medical support requirements, and budget. 

Reviewing the Best Topical Finasteride Products

With the above key factors in mind, let’s turn now to our top recommended options that each offer unique advantages sure to satisfy. 

#1: Ulo Finasteride + Minoxidil Plus Rx

Pros:	Cons:
✓ Clinically-proven combination therapy	✗ Prescription products are only available in the USA
✓ True personalization with custom concentrations and medical consultations
✓ PhD-scientist formulated
✓ Ongoing medical monitoring and a user-friendly platform
✓ Quality-tested ingredients free of irritants

Ulo’s combination formula of high-strength finasteride with prescription-grade minoxidil takes the top spot, reflecting the platform’s commitment to providing safe, scientifically proven hair loss treatments tailored to meet individual needs. Every Ulo product is developed by a team of PhD scientists who deliver innovative interventions in hair restoration.

Their advanced finasteride and minoxidil solution blocks DHT and stimulates new growth in a targeted dual treatment that is proven superior to monotherapies in clinical trials. Ulo’s finasteride formulas are uniquely customizable and available in different concentrations (0.005% for maintenance and 0.2% for stronger protocols), with a series of synergistic add-ons like caffeine to boost circulation, tretinoin for better absorption, and melatonin for antioxidant protection.

The deluxe treatment begins at $64 per month, which includes an onboarding medical consultation to assess each client’s needs, a physician-crafted treatment plan, and continued dermatologist oversight. All Ulo products are strictly sourced from pharmacies that adhere to safety and quality regulations. The clinic’s licensed dermatologists provide customized treatment regimens with free home prescription deliveries and ongoing support.

Bottom Line: Ulo’s individualized hybrid treatment is the ultimate in advanced hair restoration technology. With precise formulation and continuous medical supervision, this tailored solution delivers exceptional results for a low monthly subscription fee starting at $64. Ulo’s guiding dedication to safety and efficacy makes this full-service platform the best option for those who are serious about combating hair loss.

#2 Strut Finasteride Hair Loss Formula

Pros:	Cons:
✓ Custom-compounded topical finasteride formulas (with optional add-ons)	✗ Not available internationally, and currently cannot ship to Arkansas
✓ Online consult and prescriptions from U.S. board-certified physicians	✗ Auto-refills by default; some reviews report difficulty canceling and customer service gaps
✓ Multiple formulation options (gel or solution; adjustable finasteride strength)
✓ Convenient telehealth model with free, discreet shipping in most U.S. states.

Strut Health is a U.S.-based telehealth provider offering customized topical finasteride for AGA. After an online questionnaire and photo-based evaluation, a board-certified clinician designs a compounded formula that may contain finasteride alone or in combination with other actives like minoxidil, tretinoin, fluocinolone, or biotin. The company’s finasteride hair-loss formulas typically use 0.1-0.25% topical finasteride, with optional minoxidil concentrations up to 7.5% and tretinoin in a gel or solution base, giving flexibility to tailor potency and tolerability.

Our in-house lab testing showed that Strut Health’s finasteride product contained the correct concentrations of ingredients (finasteride, minoxidil, and tretinoin), indicating that they can be trusted to provide a quality product.

However, there are trade-offs. Strut does not accept insurance, and pricing for topical finasteride (often around the mid-range of the telehealth market) may add up for long-term use. The company currently ships to nearly all U.S. states but cannot ship to Arkansas, and there is no international service. Public reviews highlight convenience for many users but also recurring concerns about auto-refills and difficulty canceling, as well as frustration with customer support responsiveness and refund policies. 

Bottom Line: Strut Health’s topical finasteride offers a flexible, telehealth-delivered alternative for patients who want DHT-targeted treatment without taking a daily pill, with customizable formulas that can include or exclude minoxidil and other actives. Its convenience, physician oversight, and compounding flexibility are strong advantages, but subscription-based pricing and mixed customer service reviews may give more budget-conscious patients pause.

#3 Happy Head Topical Super Solution: Finasteride, Minoxidil & Liposomal

Pros:	Cons:
✓ Medical oversight by board-certified dermatologists	✗ Price rises from $59 to $99 after the first six months
✓ Higher concentrations of 0.3% finasteride + 8% minoxidil	✗ Higher concentrations may increase side effect risk
✓ Made with a delayed-release liposomal base	✗ Gel formula cannot be customized
✓ User-friendly platform and follow-up care	✗ May irritate sensitive skin
✓ Affiliate programs available	✗ Possible shipping and customer service concerns

Our next selection is from Happy Head, known for unique formulations and dermatologist oversight. The Topical Super Solution features a more concentrated combination of 0.3% finasteride with 8% minoxidil for targeted hair restoration. 

Available in a mess-free pump dispenser, this gel is made with the brand’s proprietary liposomal delivery base that boosts scalp penetration with timed medication release and once-daily application. This helps minimize bloodstream absorption, reducing potential side effects, and is a notable safety feature for higher finasteride doses. That said, some ingredients in the carrier base should not be used on sensitive skin. Other products from the brand are more customizable and can be adapted to sensitive skin.

The starting price of Happy Head’s treatment is competitive at $59 for a monthly subscription that covers dermatologist oversight and prescription deliveries. However, the price increases to $99 after the first six months. Some reviews cite a lack of transparency regarding potential side effects, as well as intermittent shipping delays and inconsistent customer service. 

Bottom Line: Happy Head’s potent dual therapy is a useful option for patients with intermediate to severe hair loss and normal skin. The delayed-release gel base increases medication absorption for more targeted treatment while decreasing systemic side effects and requires application only once a day. Advantages include dermatologist support and attractive pricing, but patients should be aware of reviews citing shipping and customer service issues. 

#4: Roman (Ro) Hair Solution Rx

Pros:	Cons:
✓ Transparent and competitive price of $50 per month	✗ Contains potential irritants not suitable for sensitive skin
✓ High finasteride concentration (0.3%) for aggressive treatment	✗ High fixed concentration with a greater risk of side effects
✓ Includes minoxidil and tretinoin for synergistic effects	✗ Limited customization options
✓  Convenient once-daily application	✗ Standard delivery system lacks advanced features
✓ Established telehealth provider with medical supervision

Roman offers a simple topical finasteride formula designed for convenient, once-daily use and focused intervention. The spray contains three active ingredients: high-dose 0.3% finasteride with 6% minoxidil and tretinoin to enhance absorption. This product delivers a potent dose of finasteride on par with premium rivals through a no-frills spray system.

While tretinoin may improve minoxidil absorption, Roman’s spray has some drawbacks for users with sensitive skin or systemic side effect concerns. The 0.3% finasteride concentration cannot be tailored to individual response, and the standard delivery system does not have delayed-release technology to offset the risk of systemic absorption as seen in Happy Head’s liposomal gel. Inactive ingredients like ethyl alcohol and propylene glycol are also known irritants.

Roman is an accessible option for many users. The transparent and fixed monthly fee of $50 covers doctor consultations, prescription deliveries, and unlimited follow-ups. However, users with sensitive skin or more complex treatment needs may find Roman’s standardized and less gentle formulation to be unsuitable for long-term compliance.

Bottom Line: Roman offers a potent and affordable dual finasteride therapy with telehealth support features. Although it is not customizable like leading alternatives, this spray is a convenient choice for individuals with moderate to severe hair loss who can tolerate high dosages and potential irritants.

#5: Hims Topical Finasteride & Minoxidil Spray

Pros:	Cons:
✓ Lowest starting rate of $35+/month	✗ Standardized approach that lacks customization
✓ Well-known brand with recognized platform	✗ Minimal ongoing medical support
✓ Simple ordering process and rapid shipping	✗ Contains irritants not suitable for sensitive skin and fixed high dose
✓ No lengthy consultations required	✗ Basic telehealth features without specialist care
✓ High-dose dual treatment	✗ Concerns about the price transparency of subscription tiers

Hims is a well-known brand that offers topical finasteride through its streamlined telemedicine platform. Their fixed-dose spray of 0.3% finasteride and 6% minoxidil is a convenient and affordable option without the customization features of premium competitors, appealing to those who value simplicity over tailored care. 

Like similar high-dose sprays, this standardized formula from Hims is not suitable for patients with sensitive skin, complex treatment needs, or those requiring a lower maintenance dose.

This provider’s appeal is its wide accessibility. With low prices starting at just $35 per month, quick doctor consultations, and shipping in all 50 states, Hims is a gateway brand for many new hair loss patients. However, this entry-level approach lacks the treatment personalization and close medical supervision of established specialty providers. 

Bottom Line: Hims’ topical finasteride spray is an affordable and easily accessible option backed by a recognized brand name. Although Hims fails to offer the precision treatment and close medical oversight of premium alternatives, it is a mainstay for patients who prioritize low costs and convenience.

Final Verdict: Our Topical Finasteride Picks

After a comprehensive evaluation, Ulo emerges as our top choice for topical finasteride in 2025. Their genuine customization, science-backed formulations, and ongoing dermatologist supervision set the gold standard for personalized hair restoration.

While competitors offer standardized protocols or unproven technologies, Ulo delivers verified results through precision medicine tailored to individual needs. For patients seeking the highest quality care, Ulo’s scientific rigor and safety-first approach make it the clear winner.

What to Expect: Timeline and Results 

Realistic treatment expectations facilitate long-term compliance and successful outcomes. Medical research has established the following evidence-based benchmarks of expected improvements with topical finasteride use as prescribed to treat androgenetic alopecia.

Clinical Timeline for Topical Finasteride Results

Timeframe	What to Expect	Clinical Evidence
3 Months	Terminal hair count starts to improve; increases in total hair count may not yet be observable	[10]​​B. Piraccini et al. (2021). Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial. Journal of the European … Continue reading,[11]Cheng Zhou et al. (2025). Efficacy and safety of topical finasteride spray solution in the treatment of Chinese men with androgenetic alopecia: A phase III, multicenter, randomized, double-blind, … Continue reading
6 Months	Noteworthy increases in hair counts (total and terminal); visible increase in vertex hair growth	[12]​​B. Piraccini et al. (2021). Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial. Journal of the European … Continue reading,[13]Cheng Zhou et al. (2025). Efficacy and safety of topical finasteride spray solution in the treatment of Chinese men with androgenetic alopecia: A phase III, multicenter, randomized, double-blind, … Continue reading,[14]A. Rossi et al.  (2020). Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 … Continue reading
12-18 Months	Maximum improvement is typically observed; continuous improvements in hair coverage and density	[15]A. Rossi et al.  (2020). Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 … Continue reading

• Early Treatment Phase (Months 1-3): During early treatment, visible changes are minimal, which may be disappointing for new patients. The therapy begins to suppress scalp DHT levels, creating shifts that are not yet cosmetically evident. Studies show that improvements in terminal hair count begin around 3 months, though total hair count is not yet typically impacted. 

In the first 6-8 weeks, some experience a temporary increase in shedding as finasteride prompts new growth cycles to start. This is expected and is an encouraging indication that the treatment is taking effect. 

• Visible Improvement Phase (Months 3-6): Visible results begin to appear during this period. Studies show notable increases in hair counts and density by 6 months. Patients tend to note particular improvements in the crown or vertex region.
  
• Optimization Phase (Months 6-18): The most significant benefits occur during this phase. Research indicates that maximum improvements arise around 12 months of continued treatment, as hair density and new growth quality increase.
  
• Long-Term Maintenance: According to clinical data, benefits stabilize around 18-24 months, and treatment transitions from active regrowth to maintenance. Because treatment cessation can lead to the gradual return of hair loss within 6-12 months, continued daily compliance is essential to maintain long-term therapeutic outcomes. 

Topical Delivery Formats

There are several different topical finasteride delivery formats that each offer unique advantages to suit individual needs and preferences, as follows:

• Solutions are liquid formulas typically applied using a dropper for targeted administration on desired scalp areas. These lightweight preparations are valued for their excellent absorption and residue-free finish. Because solutions may contain irritating excipients such as propylene glycol, sensitive patients should opt for gentle blends like Ulo’s prescription topicals. 
• Sprays are a lighter, more fluid type of solution applied using an aerosol or pump. This form enables misting over larger or difficult-to-reach scalp areas. However, sprays are not as precise as droppers, as the liquid may run off and fail to effectively reach the hair follicles.
• Gels offer a more controlled application with a thicker consistency than solutions. They often include advanced delivery bases such as liposome carriers with delayed-release technology, designed to enhance penetration and reduce systemic absorption. However, customization options are typically limited due to compounding practices. Additionally, gel formulas can leave a sticky residue that some users find undesirable.
• Foams may be beneficial for patients with sensitive skin, as they dry quickly and generally lack harsh additives. However, their capacity for targeted application is limited compared to other formulations. 
• Creams and lotions are appropriate for sensitive or dry scalps, featuring thick, emollient-laden bases with moisturizing benefits. Lotions are generally faster-absorbing, more spreadable, and lighter than creams.

The best formulation choice depends on hair and skin type, lifestyle, and personal preferences. Patients are encouraged to consult a doctor to determine the ideal format for their individual needs. 

Safety and Side Effects 

Topical finasteride is noted for its favorable safety profile, especially in contrast to oral formulations; however, understanding potential risks and proper monitoring practices is recommended.

• Common Mild Side Effects: The most common side effects are transient and mild scalp irritation or dryness. Though these reactions often resolve on their own, they also respond well to dose adjustment or calming adjunctive treatments. Patients with sensitive skin should avoid formulas containing irritants like propylene glycol or parabens.^[16]Lee, S.W, Juhasz, M., Mobasher, P., Ekelem, C., Mesinkovska, N.A. (2018).  A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. Journal of Drugs in … Continue reading,^[17]Piraccini, B.M., Blume-Peytavi, U., Scarci, F., Jansat, J.M., Falques, M., Otero, R., Tamarit, M.L., Galvan, J., Tebbs, V., Massana, E. (2021). Efficacy and safety of topical finasteride spray … Continue reading 
• When to Contact Your Doctor: More serious side effects or reactions are rare but possible and require prompt medical intervention. These include severe scalp irritation, allergic reactions (blistering, swelling, and redness), and systemic effects like mood changes, sexual dysfunction, or gynecomastia.^[18]Suchonwanit, P., Iamsumang, W., Leerunyakul, K. (2020). Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature. Journal … Continue reading,^[19]Cheng Zhou et al. (2025). Efficacy and safety of topical finasteride spray solution in the treatment of Chinese men with androgenetic alopecia: A phase III, multicenter, randomized, double-blind, … Continue reading
  
• Topical vs. Oral Finasteride Safety: Clinical data show that topical finasteride has a significantly lower risk of sexual side effects, typically less than 2% compared to 8-15% with oral formulations. This is attributed to the targeted delivery of topical preparations that limit systemic exposure while providing localized scalp treatment.^[20]Mysore, V. (2012). Finasteride and sexual side effects. Indian Dermatology Online Journal, 3(1), 62. https://doi.org/10.4103/2229-5178.93496.
  
• Who Should Avoid Topical Finasteride: Topical finasteride is not suitable for women who are pregnant or nursing due to the risk of birth defects or infant harm. Additionally, individuals with known sensitivity, scalp infections, or certain autoimmune diseases may be ineligible for use. Consult with a doctor before beginning treatment. 

Closing Thoughts 

Topical finasteride is an important development in hair loss therapeutics, providing comparable results with a superior safety profile to oral medications. In today’s market, Ulo’s individualized, clinically rigorous approach sets a benchmark for comprehensive care, outperforming competitors primarily focused on budget or convenience factors.

Successful treatment with topical finasteride requires patience and persistence. Advances in hair restoration technology suggest that tailored medicine, rather than standardized approaches, represents the future. Ready to begin your own journey toward hair restoration? 

Visit Ulo today to see how customized topical finasteride can enhance your results.

Frequently Asked Questions

Do I need a prescription for topical finasteride?

Yes, topical finasteride is a prescription-only medication in the USA. This ensures proper diagnosis, medical supervision, dosage, and quality control. Reputable telehealth providers like Ulo make the prescription process quick and easy via video consultations with licensed doctors specialized in hair restoration therapies. These elite platforms also offer ongoing medical supervision to monitor side effects and adjust treatment for optimization.

Avoid online platforms that market finasteride products without a prescription or those that fail to perform a proper medical consultation before prescribing treatment. Reputable platforms employ board-certified doctors licensed to practice in your state of residence with credentials clearly displayed or offered upon request. Sourcing topical finasteride products from unauthorized vendors without a prescription risks hazardous side effects and ineffectiveness.

Can topical finasteride be used with other hair loss treatments?

Yes, topical finasteride can be beneficially combined with treatments like minoxidil, a popular additive in many available products. These formulas often pair finasteride with additional synergistic ingredients such as antioxidants, vasodilators, antifungals, and absorption enhancers. 

Topical finasteride can also be safely used in conjunction with most non-prescription hair products, hair transplants, and low-level laser treatments. However, it should not be combined with oral DHT blockers (i.e., oral finasteride or dutasteride) due to the risk of systemic side effects. Medical approval is necessary before starting new treatments. 

When will I see results with topical finasteride?

Most patients report stabilization of hair loss after 3-4 months, with notable regrowth in 6-12 months. Shedding within the first 6-8 weeks of starting treatment is considered normal and indicative of the treatment’s efficacy. Because DHT suppression takes time to significantly impact hair growth cycles, consistency and patience are essential for optimal treatment outcomes.

Treatment outcomes can vary between individuals. Consult a doctor to discuss influencing factors and form realistic treatment expectations. This grounded approach facilitates better long-term adherence and more desirable results.  

Is topical finasteride suitable for women?

Although the FDA has not yet authorized topical finasteride to treat AGA in women, it is occasionally prescribed for off-label use in postmenopausal patients with female pattern hair loss (FPHL). Because topical finasteride risks fewer hormonal adverse effects than oral finasteride, it is considered a safer option in these cases. 

However, women of reproductive age are often recommended to completely avoid finasteride due to the risk of severe birth defects from exposure while pregnant. Non-pregnant women who may plan for pregnancy in the future should abstain from finasteride use unless under strict medical supervision with suitable contraception established. Newer low-dose formulations designed for women show promise, although more study is needed to verify long-term viability.

Ultimately, women considering finasteride therapy should speak with an experienced clinician to go over their medical history, weigh the benefits and risks, and review alternative treatment options, such as FDA-approved topical minoxidil.

What is the cost of topical finasteride without insurance? 

The average monthly cost of topical finasteride without insurance can vary from $35 to $90, depending on the source, formulation, and services rendered. Direct-pay telehealth providers tend to offer lower rates than conventional in-person dermatology clinics with combined pharmacy fees. Bespoke formulas with advanced excipients can command higher prices. Patients should account for continued costs to budget for long-term treatment, which is often required for beneficial outcomes. 

What will happen if I stop using topical finasteride? 

If regular topical finasteride treatment is discontinued, hair loss is expected to return gradually within 2-3 months of cessation. Most patients report a rebound to their baseline hair loss level within 6-12 months. Because this regression is gradual, patients have some flexibility regarding therapy breaks or medication transitions if needed. 

Does topical finasteride have any drug interactions?

Compared to oral finasteride, topical formulations have few contraindications due to lower systemic absorption rates. For your safety, inform your prescribing doctor of all current medications, especially blood thinners and other hormonal drugs. While topical finasteride is often safely combined with common medications, there may be exclusions. 

How do I store topical finasteride? 

Topical finasteride should be kept at room temperature out of direct light, moisture, and heat. With proper storage, most products maintain stability for 12-24 months. While refrigeration isn’t required, it may boost shelf life in temperate climates. Be sure to check expiration dates and safely dispose of expired products. 

Can I travel while on topical finasteride? 

Yes, prescribed topical finasteride may be stored in carry-on luggage during domestic travel. When traveling internationally, it is recommended to bring the original prescription and label. Be mindful of TSA restrictions on liquid volumes over 3.4 oz.

How is topical finasteride applied?

Topical finasteride is applied directly to a clean and dry scalp with the product applicator. While specific instructions vary with delivery method, in general, the hair should be parted to expose the scalp and allow targeted application to the desired areas. Patients should consult product instructions for precise indications and dosing protocols. Avoid wetting hair for several hours after application, and thoroughly wash hands after use.

Minoxidil is a widely used medication for treating androgenic alopecia (AGA) in both men and women. Originally developed as a treatment for high blood pressure, minoxidil was found to improve hair growth outcomes as a side effect, making its topical form one of only two (the other being finasteride) FDA-approved treatments for AGA. 

Minoxidil is primarily available in two forms: topical and oral. The topical form, which includes both solutions and foams, is more commonly used and can be purchased over the counter. Oral minoxidil, however, is prescription only and is typically given at doses of 2.5 mg or 5 mg for hair loss treatment.

While minoxidil is generally considered safe, it’s important to understand its potential side effects and who might be more at risk from them. In this article, we will examine the side effects of topical and oral minoxidil and discuss how you can adjust your treatment regimen to mitigate these.

Interested in Topical Minoxidil?

High-strength topical minoxidil available, if prescribed*

Take the next step in your hair regrowth journey. Get started today with a provider who can prescribe a topical solution tailored for you.

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*Only available in the U.S. Prescriptions not guaranteed. Restrictions apply. Off-label products are not endorsed by the FDA.

How Does Minoxidil Work?

Minoxidil was originally developed as an antihypertensive medication. However, when treated participants started experiencing hypertrichosis (excessive hair growth), studies were conducted to find out if it could improve hair regrowth outcomes in humans (spoiler alert – it could!).^[1]Bryan, J. (2011). How minoxidil was transformed from an antihypertensive to hair-loss drug. The Pharmaceutical Journal. Available at: … Continue reading

Minoxidil’s mechanism of action is not fully understood, but it is thought to work through two main mechanisms:

• Vasodilatory effects: It activates vascular endothelial growth factor (VEGF), increasing blood flow, oxygen, and growth factor delivery to the hair follicle.^[2]Alhayaza, G., Hakami, A., AlMarzouk, L.H., Al Qurashi, A.A., Alghamdi, G., Alharithy, R. (2023). Topical minoxidil reported hair discoloration: a cross-sectional study. Dermatology Reports. 16(1). … Continue reading 
• Potassium channel activation: This prolongs the growth (anagen) phase and shortens the resting (telogen) phase. 

Research also shows that minoxidil can act on androgenic receptors, suppressing the expression of the androgen receptor and CYP17A1 and boosting the activity of CYP19A1. This decreases the formation and binding of dihydrotestosterone and enhances the production of estradiol, which may also benefit those with AGA.^[3]Shen, Y., Zhu, Y., Zhang, L., Sun, J., Xie, B., Zhang, H., Song, X. (2023). New Target for Minoxidil in the Treatment of Androgenetic Alopecia. Drug Design, Development and Therapy. 17. 2537-2547. … Continue reading 

How is Minoxidil Activated in the Body?

Minoxidil needs to be converted into its active form, minoxidil sulfate, by sulfotransferase enzymes before it can effectively stimulate hair growth.^[4]Dhurat, R., Daruwalla, S., Pai, S., Kovacevic, M., McCoy, J., Shapiro, J., Sinclair, R., Vano-Galvan, S., Goren, A. (2021). SULT1A1 (Minoxidil Sulfotransferase) enzyme booster significantly improves … Continue reading This conversion primarily occurs in the scalp for topical minoxidil and in the liver for oral minoxidil.

However, enzyme activity varies significantly among individuals, meaning that some people naturally produce higher levels of sulfotransferase, allowing for better activation and increased effectiveness of the drug, while others have lower enzyme activity, which can limit its impact. You can read our article on how your genetics can influence sulfotransferase activity here.

Topical Minoxidil Vs. Oral Minoxidil: Activation Pathways

Topical minoxidil and oral minoxidil differ in application and effectiveness. Topical minoxidil is applied directly to the scalp, while oral minoxidil is taken as a pill. 

The efficacy of these two treatment routes differs because of their distinct metabolic pathways. 

Topical Minoxidil

Topical minoxidil is applied directly to the scalp, presenting a challenge for drug activation. The drug requires conversion to its active form, minoxidil sulfate, by sulfotransferase enzymes in the scalp. However, research has shown that 40-60% of people may lack sufficient enzyme levels to effectively activate the medication. This enzymatic variability means that for many users, topical minoxidil may not be 100% effective.

Around 1.4% of topical minoxidil is systemically absorbed, further limiting minoxidil efficacy. To counteract this limitation, researchers have explored combining minoxidil with treatments like microneedling or retinoic acid. It was found that with these combinations, minoxidil efficacy can significantly increase.^[6]Lama, S.B.C., Pérez-González, L.A., Kosoglu, M.A., Dennis, R., Ortega-Quijano, D. (2024). Physical Treatments and Therapies for Androgenetic Alopecia. Journal of Clinical Medicine. 13(15). 4534. … Continue reading 

Oral Minoxidil

Oral minoxidil, however, is metabolized in the liver, where sulfotransferase enzymes are abundant. The activated minoxidil sulfate then enters the bloodstream, where it reaches the hair follicle. Studies consistently demonstrate higher response rates for oral minoxidil compared to topical.^[7]Gupta, A.K., Talukder, M., Venkataraman, M., Bamimore, M.A. (2022). Minoxidil: a comprehensive review. Journal of Dermatological Treatment. 33(4). 1896-1906. Available at: … Continue reading However, because oral minoxidil involves systemic absorption, it comes with a broader potential for side effects.

What Are the Side Effects of Topical Minoxidil?

Common Side Effects

While topical minoxidil typically has a great safety profile, there are some side effects that people can experience.

Common side effects include:

• Scalp Irritation and Contact Dermatitis: Redness, itching, flaking, and burning sensations. 

These are the most frequently reported side effects from minoxidil. One retrospective study found that 6.4% of men reported mainly irritant and allergic reactions to minoxidil.^[8]Shadi, Z. (2023). Compliance to Topical Minoxidil and Reasons for Discontinuation among Patients with Androgenetic Alopecia. Dermatology and Therapy (Heidelb). 13(5). 1157-1169. Available at: … Continue reading These effects are typically due to an allergic reaction to propylene glycol rather than the minoxidil itself.^[9]Lessmann, H., Schnuch, A., Geier, J., Uter, W. (2005). Skin-sensitizing and irritant properties of propylene glycol. Contact Dermatitis. 53(5). 247-259. Available at: … Continue reading 

To mitigate the negative skin effects of topical minoxidil, you can do several things. Starting with a lower concentration, such as 2% instead of 5%, can reduce the risk of irritation while still providing benefits. Additionally, reducing application frequency from twice to once daily can limit exposure. Switching to a foam-based minoxidil product can be particularly effective, as these formulations typically don’t contain propylene glycol, which is often responsible for uncomfortable side effects like irritation, redness, and scalp burning. Furthermore, incorporating a moisturizer into your scalp care routine can help keep the skin hydrated and comfortable, further alleviating potential irritation.

• Shedding Phase: Temporary increase in hair loss when starting treatment.

One study reported that 55% of topical minoxidil users experience minoxidil shedding.^[10]Ghonemy, S., Bessar, H., Alarawi, A. (2019). Efficacy and safety of a new 10% topical minoxidil versus 5% topical minoxidil and placebo in the treatment of male androgenetic alopecia: a trichoscopic … Continue reading This is considered a normal side effect and usually indicates that the treatment is working. The shedding phase typically begins 2 to 4 weeks after starting treatment and subsides within 6 to 8 weeks as the hair cycle normalizes. After a few months of continuous use, most users should start seeing visible new hair growth.^[11]Kaiser, M., Abdin, R., Gaumond, S.I., Issa, T. N., Jiminez, J.J. (2023). Treatment of androgenetic alopecia: current guidance and unmet needs. Clinical Cosmetic and Investigational Dermatology. 16. … Continue reading 

• Facial Hypertrichosis: Unwanted excess facial hair. 

Women, especially those over 50 or with pre-existing facial hair, seem to be at higher risk of developing hypertrichosis from topical minoxidil use, and as with other side effects, it is more common when using the 5% than the 2% concentration.^[12]Dawber, R.P.R, Rundegren, J. (2003). Hypertrichosis in females applying minoxidil topical solution and in normal controls. Journal of the European Academy of Dermatology and Venereology. 17(3). … Continue reading 

There are several theories for why hypertrichosis occurs in people using topical minoxidil. 

1. Product application: The product wasn’t applied carefully enough or was not completely dried before bed, leading to product transfer from the pillow to the face. However, this doesn’t account for hypertrichosis seen away from the site of application and is unlikely to cause the effects seen in case studies.
2. Percutaneous absorption: Although topical minoxidil is primarily intended for local effects, a small amount can be absorbed systemically through the skin. This can lead to circulating minoxidil reaching hair follicles in distant areas of the body. 
3. Follicular hypersensitivity: Some people may have hair follicles that are exceptionally responsive to minoxidil. In these cases, even minimal systemic exposure might be sufficient to stimulate hair growth in distant follicles. This hypersensitivity appears to occur randomly, depending on the person.
4. Dose-dependent response: Higher concentrations are more likely to cause hypertrichosis.

While hypertrichosis can occur, it is generally reversible once minoxidil treatment is stopped and typically resolves within 3-4 months.

There are a number of ways that hypertrichosis can be avoided or treated once it occurs. 

Starting with a lower concentration can reduce the risk, especially for women and those with a history of excess facial hair. Careful application to the scalp only, allowing proper drying time, and adhering to the recommended dosage can also minimize systemic absorption and unintended spread.

Switching to a foam version may help those experiencing side effects. If you are experiencing mild hypertrichosis and don’t want to stop using minoxidil, you could use hair removal methods while continuing treatment. 

For more severe cases, spironolactone (~25 mg daily) ando/or low-dose bicalutamide (~10 mg daily) have shown promise in managing minoxidil-induced hypertrichosis. However, these medications should be used under medical supervision.^[14]Darendeliler, F., Bas, F., Balaban, S., Bundak, R., Demirkol, D., Saka, N., Gunoz, H. (1996). Spironolactone therapy in hypertrichosis. European Journal of Endocrinology. 135(5).604-608. Available … Continue reading,^[15]Moussa, A., Kazmi, A., Bakhari, L., Sinclair, R.D. (2022). Bicalutamide improves minoxidil-induced hypertrichosis in female pattern hair loss: a retrospective review of 35 patients. Journal of the … Continue reading 

• Headaches

Some people also experience headaches after using topical minoxidil. One study found that in users applying 2% minoxidil solution, 0.6% reported headaches, compared to 3% of participants using 5% minoxidil solution.^[16]Suchonwanit, P., Thammarucha, S., Leerunyakul, K. (2019). Minoxidil and its use in hair disorders: a review. Drug Design, Development and Therapy. 13. 2777-2786. Available at: … Continue reading

Some people may simply experience headaches due to the smell of the product they are using, in which case, switching to an alcohol-free or unscented alternative may help. Others may be particularly sensitive to minoxidil and its vasodilatory effects, which might contribute to headaches. In this case, switching to a lower concentration or consulting with a healthcare provider might be preferable.

Some of our members have also switched to nanoxidil, an analogue of minoxidil that may offer a better safety profile (you can read more about the research quality of nanoxidil here), and found that their headaches resolved.

The above side effects are more often seen in the 5% than 2% solutions and are typically considered to be non-serious.^[17]Nestor, M.S., Ablon, G., Gade, A., Han, H., Fischer, D.L. (2021). Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. Journal of … Continue reading

Some of the rarer side effects include:

• Water Retention

While less common than with oral minoxidil, topical minoxidil application can lead to water retention. Some topical minoxidil users have reported under-eye bags, which may be due to increased water retention near the application areas. There are also anecdotal reports of “puffy face” from topical minoxidil application, suggesting localized fluid retention.^[18]Gungor, S., Kocaturk, E., Topal, I.O. (2015). Frontal Edema Due to Topical Application of %5 Minoxidil Solution Following Mesotherapy Injections. International Journal of Trichology. 7(2). 86-87. … Continue reading 

Anecdotally, there have also been reports of swollen feet and weight gain from using topical minoxidil; however, we couldn’t find these reports reflected in peer-reviewed literature. These effects may also stop with continued use of the drug, so some people keep an eye on the symptoms and wait to see if they go away.

However, you can try reducing the concentration or frequency of usage if the symptoms continue longer than you are comfortable with. Furthermore, excessive salt intake can exacerbate symptoms of edema. Limiting salt intake may help you resolve the edema without having to stop using minoxidil.^[19]Patel, P., Nessel, T.A., Kumar, D. (2023). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482378/ (Accessed: … Continue reading

• Cardiovascular Issues

Some people also experience cardiovascular side effects. One case study found that applying large amounts of 2% topical minoxidil led to hypotension (low blood pressure) and feelings of faintness.^[20]Ponomareva, M.A., Romanova, M.A., Shapshnikova, A.A., Piavchenko, G.A. (2024). Topical Minoxidil Overdose in a Young Man with Androgenetic Alopecia: A Case Report. Cureus. 16(6). E62382. Available … Continue reading Another case also documented low blood pressure and fainting after applying 12.5% topical minoxidil daily.^[21]Dubrey, S.W., vanGriethuysen, J., Edwards, C.M.B. A hairy fall: syncope resulting from topical application of minoxidil. BMJ Case Reports. 1-2. Available at: https://doi.org/10.1136/bcr-2015-210945 

Other people may experience heart palpitations, feelings of the heart beating rapidly or “skipping a beat”. While this is rare, one study found that 3.5% of women developed heart palpitations or a rapid heart rate after usage of 2% topical minoxidil solution compared to 1.8% who were using a 5% foam.^[22]Blume-Peytavi, U., Hillmann, K., Dietz, E., Canfield, D., Bartels, N.G. (2011). A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the … Continue reading

Therefore, we would recommend seeking medical advice and potentially finding a new treatment for hair loss if you experience these side effects.

So we’ve covered the side effects of topical minoxidil, but what about oral?

What Are the Side Effects of Oral Minoxidil?

Oral minoxidil side effects are similar to those of topical minoxidil, and both forms exhibit dose-dependent effects. However, oral administration leads to significantly greater systemic exposure to the drug than topical application. As a result, oral minoxidil typically produces more pronounced hair regrowth and more pronounced systemic side effects. It should be noted that use of oral minoxidil to improve hair regrowth is an off-label use of the drug and it is not FDA-approved for this indication.

Common Side Effects

• Hair Shedding

Like with topical minoxidil, you may experience increased hair shedding when you start taking minoxidil. This is considered to be a normal part of the hair cycle remodeling process, typically beginning two to four weeks after starting treatment and subsiding within six to eight weeks as the hair cycle normalizes. 

• Hypertrichosis

While rare with topical minoxidil use, one of the most frequently reported side effects of oral minoxidil is hypertrichosis, which involves excessive hair growth on various parts of the body. This effect is dose-dependent, with some studies showing that increasing the dosage of oral minoxidil by just 1 mg daily is associated with a 17.6% increased risk of hypertrichosis.^[23]Gupta, A.K., Hall, D.C., Talukder, M., Bamimore, M.A. (2022). There is a Positive Dose-Dependent Association between Low-Dose Oral Minoxidil and Its Efficacy for Androgenetic Alopecia: Findings from … Continue reading 

Hypertrichosis frequently occurs on the face (sideburns, temples, upper lip, and chin), with rarer cases of generalized hypertrichosis occurring over the whole body.^[24]Desai, D.D., Nohria, A., Brinks, A., Needle, C., Shapiro, J., Lo Sicco, K.I. (2024). Minoxidil-induced hypertrichosis: Pathophysiology, clinical implications, and therapeutic strategies. JAAD … Continue reading 

• Fluid Retention

Fluid retention is another common side effect of oral minoxidil, occurring in about 1.3% of patients.^[25]Trueb, R.M., Caballero-Uribe, N., Luu, N.N.C., Dmitriev, A. (2022). Serious complication of low-dose oral minoxidil for hair loss. JAAD Case Reports. 30. 97-98. Available at: … Continue reading This can manifest as mild swelling in the face, hands, or feet. In some cases, it may lead to rapid weight gain. 

This weight gain can be significant and sudden, with some patients experiencing up to 20 pounds of weight gain (as water weight) in as little as one month.^[26]Patel.K., Omar, J. (2023). Low dose oral minoxidil causing peripheral edema and rapid weight gain. Journal of General Internal Medicine. 38(Suppl 3). S592. Available at: … Continue reading

Fluid retention can manifest in several ways:

1. Peripheral edema: Swelling in the extremities, particularly in the legs, ankles, and feet.
2. Facial swelling: Puffiness or swelling in the face.
3. Overall weight gain: A sudden increase in body weight, often 5 pounds or more.

This rapid retention can be concerning for patients and may lead to additional health risks if left unmanaged. Excess fluid in the body can potentially lead to congestive heart failure if not properly addressed.

To mitigate these side effects, there are a number of options:

• Use of diuretics: Doctors can prescribe a diuretic (water pill) alongside minoxidil to help counteract fluid retention. This is typically a low-dose loop diuretic.
• Sodium restriction: Limiting sodium intake can help reduce fluid retention. Patients are often not advised about this when starting minoxidil, which can exacerbate the problem.
• Dose adjustment: If fluid retention becomes severe, temporarily discontinuing minoxidil or significantly reducing the dose may be necessary. This allows the edema to resolve naturally before restarting at a lower dose.
• Regular monitoring: Daily weight monitoring can help identify fluid retention early, making it easier to manage.
• Gradual titration: Slowly increasing the dose of minoxidil over time, rather than starting with 5 mg, can help minimize side effects.

If these symptoms don’t resolve when trying these strategies, then it’s recommended to visit your doctor and potentially stop taking minoxidil.

• Lightheadedness, Tachycardia (high heart rate), Headache and Insomnia

Oral minoxidil can cause several cardiovascular and neurological side effects, including lightheadedness, tachycardia, headache, and insomnia.^[27]Trueb, R.M., Caballero-Uribe, N., Luu, N.N.C., Dmitriev, A. Serious complication of low-dose oral minoxidil for hair loss. JAAD Case Reports. 30. 97-98. Available at: … Continue reading These effects are generally dose-dependent and more common at higher doses.

Lightheadedness has been reported to occur in 1.7% of patients, tachycardia in 0.9%, headache in 0.4%, and insomnia in 0.2% of patients. These can all be symptoms of decreased blood pressure due to minoxidil’s vasodilatory properties. 

Headaches and insomnia are reported in around 0.4% and 0.2% of patients, respectively, using low-dose oral minoxidil. While the exact mechanism of these side effects is not clear, it is thought that it could be related to the vasodilatory effects of the drug.

What Are The Cardiovascular Concerns of Oral Minoxidil Usage?

The severity and frequency of cardiovascular side effects are closely tied to the dosage of oral minoxidil. A meta-regression analysis found a positive dose-dependent correlation between low-dose oral minoxidil and the risk of cardiovascular adverse events.

Low Dose (0.25-1.25 mg/day)

At lower doses, oral minoxidil is generally well-tolerated. Women typically start with doses ≤ 1 mg, which minimizes the risk of significant side effects. Lower doses are considered to be a safer starting point for most patients, and even very low doses (0.25 mg/day) have shown efficacy in some studies.^[28]Ramírez-Marín, H.A., Tosti, A. (2022). Role of oral minoxidil in patterned hair loss. Indian Dermatology Online Journal. 13(6). 729-733. Available at: https://doi.org/10.4103/idoj.idoj_246_22 If you are experiencing side effects at higher doses, you can reduce your dose at home using a pill cutter.

Moderate Dose (2.5-5 mg/day)

Men may be prescribed up to 5 mg of minoxidil daily, which can increase the likelihood of side effects such as dizziness and fluid retention. A recent study examined the effects of 7.5 mg/day oral minoxidil in patients with normal blood pressure and AGA.^[29]Sanabria, B.D., Perdomo, Y.C., Miot, H.A., Ramos, P.M. (2024). Oral minoxidil 7.5 mg for hair loss increases heart rate with no change in blood pressure in 24 h ambulatory blood pressure monitoring. … Continue reading The results showed a mild increase in heart rate but no significant changes in blood pressure, suggesting that doses slightly higher than the typical 5 mg can be tolerated. However, this should only be considered under medical supervision.

High Dose (10 mg/day and above)

Doses above 10 mg daily are associated with a higher risk of serious cardiac events and are typically not recommended for hair loss treatment. The hypotensive effect of oral minoxidil becomes more significant at these higher doses and is often prescribed alongside beta blockers and diuretics to manage the side effects.

How Can I Mitigate Oral Minoxidil Side Effects?

We have covered a number of ways to mitigate oral minoxidil side effects, but there are some further ways that you can adjust the use of minoxidil to reduce your risk.

Split-Dosing

Splitting the daily dosage of oral minoxidil into two administrations, one in the morning and one in the evening, can potentially optimize its efficacy while minimizing side effects. This approach is based on the pharmacokinetics of oral minoxidil, which has a relatively short half-life of approximately 3-4 hours.^[31]Vano-Galvan, S., Pirmez, R., Hermosa-Gelbard, A., Moreno-Arrones, O.M., Saceda-Corralo, D., Rodrigues-Barata, R., Jiminez-Cauhe, J., Koh, W.L., Poa, J.E., Jerjen, R., de Carvalho, L.T., John, J.M., … Continue reading 

By dividing the total daily dose, you can maintain more consistent blood levels of minoxidil throughout the day, potentially leading to more stable hair growth stimulation. For example, if 5 mg is prescribed daily, taking 2.5 mg in the morning and 2.5 mg in the evening may be more beneficial than a single 5 mg dose.

Sublingual Minoxidil

Some recommend using sublingual minoxidil as an alternative to traditional oral minoxidil. Sublingual administration involves a tablet that dissolves under the tongue. One 2021 randomized, double-blind, placebo-controlled phase 1b clinical trial investigated this delivery method.^[32]Bokhari, L., Jones, L.N., Sinclair, R.D. (2021). Sublingual minoxidil for the treatment of male and female pattern hair loss: a randomized, double-blind, placebo-controlled, phase 1B clinical trial. … Continue reading The study tested daily doses of 0.45 mg to 4.05 mg of sublingual minoxidil. 

This method offers several advantages:

1. Bypasses first-pass metabolism in the liver.
2. It allows for direct entry into the bloodstream, which can travel inactivated to the scalp and be activated by sulfotransferase at the site.
3. Reduces systemic side effects.
4. Improves bioavailability.

Key findings from the study included a dose-dependent improvement in hair parameters, with reduced side effects compared to oral minoxidil and no significant effect on blood pressure. In the blood, peak serum concentrations of minoxidil were only 10% of those seen with typical oral minoxidil.

At the 24-week follow-up, approximately 45% of patients in the 0.45 mg sublingual minoxidil group experienced improvements in frontal hair density, and 55% showed vertex improvement. Higher doses (4.05 mg) led to further results, with nearly 67% of patients experiencing improvements in both frontal and vertex hair density. 

Sublingual minoxidil appears to be particularly beneficial for people concerned about the side effects of oral minoxidil. The medication was undetectable in plasma after 24 hours, and the mean peak minoxidil plasma concentration was significantly below the threshold associated with changes in blood pressure.

While the results are promising, it should be noted that this is the only study using sublingual minoxidil for AGA, and further studies with larger patient numbers are needed.

Switch To Topical Minoxidil

There is a chance that none of these options will work out for you, so you can try to switch to topical minoxidil. The side effects are more manageable for topical treatments, meaning that you can increase the dose and try to pair them with other treatments like microneedling or retinoic acid to further improve hair growth outcomes.

Can I Use Minoxidil If I Am Planning a Family?

Medical professionals generally advise against using both topical and oral minoxidil for both men and women when planning a family and for women during pregnancy and while breastfeeding.

While there is limited data on human pregnancies, animal studies have shown potential risks, including evidence of increased fetal resorption at high doses, one case report of fetal malformation associated with topical minoxidil use, and neonatal hypertrichosis reported following exposure during pregnancy.^[34]Drugs. (2023). Minoxidil pregnancy and breastfeeding warnings. Drugs.com. Available at: https://www.drugs.com/pregnancy/minoxidil.html (Accessed: February 2025),^[35]Smorlesi, C., Caldarella, A., Caramelli, L., Di Lollo, S., Moroni, F. (2003). Topically applied minoxidil may cause fetal malformation: a case report. Birth defects research. Part A, Clinical and … Continue reading 

There is a significant lack of well-controlled studies on minoxidil use during pregnancy and lactation. However, given the animal studies, medical professionals typically recommend avoiding minoxidil use when planning pregnancy, during pregnancy, and while breastfeeding, using adequate contraception if taking minoxidil, and discontinuing minoxidil use before attempting to conceive.^[36]National Institute of Health and Care Excellence. (2021). Topical minoxidil. NICE. Available at: … Continue reading

Does Minoxidil Affect Male Fertility?

Current research suggests that minoxidil has minimal to no direct impact on male fertility. However, some research has linked minoxidil with oxidative stress and morphological changes to the testicles, which could indicate a potential negative impact.^[37]Santana, F.F.V., Lozi, A.A., Goncalves, R.V., Silva, J.D., Matta, S.L.P.D. (2023). Comparative effects of finasteride and minoxidil on the male reproductive organs: A systematic review of in vitro … Continue reading 

If you’re thinking about trying minoxidil and you are trying to conceive or have a pregnant partner, then it is advisable to talk to a medical professional before starting any treatment.

What if I’m Still Experiencing Side Effects?

Fortunately, minoxidil is just one of several treatment options available. If you’ve tried all of them and still experience side effects, you might consider exploring alternative therapies.

We have a wealth of information available so you can weigh your options and find out exactly how each treatment works and what your regrowth roadmap might look like. If you have any questions, reach out in the dedicated discussion thread below.

Final Thoughts

While minoxidil remains one of the most widely used treatments for AGA, both topical and oral formulations present unique challenges. The choice of which to use should be weighed carefully against the side effects, varying from mild scalp irritation to more significant cardiovascular effects. Ultimately, while the research supports minoxidil’s efficacy, it is not the only option out there, and if it isn’t working for you, then it is important to find the right one.

Research continues to show that oral minoxidil is an effective off-label treatment for men with pattern hair loss. The general rule-of-thumb: the bigger the dose, the better hair regrowth. But there’s a catch…

Higher dosages of oral minoxidil come at a risk of higher risk of side effects: excessive body hair growth, limb swelling, low blood pressure, and even heart palpitations.

Knowing this, is there a “best dose” for oral minoxidil (in mg) for men with pattern hair loss? More specifically, which dose of oral minoxidil maximizes our chances for hair regrowth and minimizes our risks of adverse events?

This Quick Win uncovers the latest research. The short answer: studies show that 2.5mg daily seems to be a tolerable, effective dose for most men with pattern hair loss. But the right dose for you will depend on (1) your severity of hair loss, and (2) your tolerance with side effects (not all of them are bad).

Note: Quick Wins are short articles focused on answering one question about hair loss. Given their specificity, these articles are written in a more scientific tone. If you’re new to hair loss education, start with these articles.

Interested in Oral Minoxidil?

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Oral minoxidil: research at a glance

To date, there have been fewer than 10 studies published on oral minoxidil for androgenic alopecia (AGA). Doses studied range from 0.25mg to 5.0mg daily, and study durations (at least the ones we evaluated) range from 24-52 weeks.

Across studies, there is a clear trend: the higher the dose of oral minoxidil, the better the hair regrowth. But this relationship doesn’t tell the whole story ­– as these higher dosages seem to confer with higher reports of side effects.

So, here’s what you should know before starting any daily dose of oral minoxidil.

#1: Oral minoxidil dosages from 0.25mg to 5mg improve pattern hair loss

The three most recent (and most robust) studies on oral minoxidil all varied dosing by 0.25mg, 2.5mg, and 5.0mg daily. All of them showed benefit – with higher dosages demonstrating visual improvements. Just see these photos of a male who took 5mg of oral minoxidil daily for 3 months.^[1]Jimenez-Cauhe, Juan et al. Effectiveness and safety of low-dose oral minoxidil in male androgenetic alopecia. Journal of the American Academy of Dermatology, Volume 81, Issue 2, 648 – 649

Male with AGA: improvement with 5mg oral minoxidil over 3 months

So, let’s organize the findings of these three studies by dosage. Then, let’s evaluate their results in terms of:

1. Response rates (i.e., the percent of people who experienced an improvement), and…
2. Side effects (i.e., unintended effects of the drug)

Do we see any trends in data? Specifically, is there a “sweet spot” where most men can maximize their chances of hair regrowth from oral minoxidil while minimizing their risk of serious side effects?

Yes.

Oral minoxidil for AGA: study results by dosage

See each study’s summaries.

Daily Dose (Duration)	Response Rate	Side Effects
0.25 mg (6+ months)[2]Pirmez, Rodrigo et al. Very-low-dose oral minoxidil in male androgenetic alopecia: A study with quantitative trichoscopic documentation. Journal of the American Academy of Dermatology, Volume 82, … Continue reading	60%	90%: increased beard growth (52%), increased body hair (20%), hair shedding (16%), pedal edema (4%)
2.5 mg to 5 mg (6-12 months)[3]Jimenez-Cauhe, Juan et al. Effectiveness and safety of low-dose oral minoxidil in male androgenetic alopecia. Journal of the American Academy of Dermatology, Volume 81, Issue 2, 648 – 649	90%	29.3%: increased body hair (24.3%), lower limb edema (4.8%), hair shedding (2.4%)
5 mg (6 months)[4]Efficacy and safety of oral minoxidil 5 mg daily during 24-week treatment in male androgenetic alopecia. Journal of the American Academy of Dermatology, Volume 72, Issue 5, AB113	100%	100%: increased body hair growth (93%), pedal edema (10%), heart / EKG alterations (10%)

At first glance, the risk of side effects across even small dosages seems ridiculously high (90%+).

However, not all of these side effects are bad.

For instance, of the side effects reported in these studies, the overwhelming majority of them constituted increased body/facial hair growth. Most men aren’t going to care about this. In fact, man men might even prefer more body or facial hair.

Secondly, increased hair shedding was generally only reported at the beginning of each study. This is because, when starting minoxidil (topical or oral), the drug can “kickstart” a new anagen (growth) phase of hairs affected by androgenic alopecia (AGA). This can lead us to shed any hairs that were already primed to fall out soon anyway – specifically, catagen or telogen hairs – thereby giving the illusion of thinner hair in the first 1-2 months of treatment. However, as these hairs grow back, they’re usually much thicker, and thereby improve hair density. Long-story short: in most cases, hair shedding from minoxidil isn’t long-lived.

So, for this exercise, let’s discount increased body/facial hair growth and increased hair shedding as temporary and/or non-problematic side effects. Instead, let’s re-run our analysis and only consider serious side effects – edema, EKG alterations, etc.

Within this context, are all dosages of oral minoxidil as scary?

No. In fact, it seems like there’s a “sweet spot” for oral minoxidil where we can maximize hair regrowth while minimizing our risk of bad side effects: at 2.5mg daily.

Keep in mind the following chart is based on preliminary data on low-dose oral minoxidil, and that this article reflects the clinical studies available on oral minoxidil for androgenic alopecia as of 2020. As better-designed studies are published, these numbers will evolve:

Moreover, it’s really only at dosages of 5mg that we see an appreciable increase in concerning side effects – namely, edema (water retention / swelling) and cardiac alterations (i.e., lower heart rates).

So, 2.5 mg daily of oral minoxidil might be the “sweet spot” for most male pattern hair loss sufferers.

#2: Oral minoxidil’s efficacy may vary depending on hair loss severity

Most clinical trials on androgenic alopecia will select study participants who all have similar severities of hair loss. This is known as standardization. And for most trials, investigators usually prefer men who have medium-severity androgenic alopecia (i.e., Norwood 3-4). This is usually because men with Norwood 3-4 level hair loss (1) are representative of the population of hair loss sufferers who may later opt for this treatment, and (2) have enough hair follicle miniaturization and hair loss to effectively evaluate cosmetic improvements to hair thinning.

Having said that, most studies on oral minoxidil aren’t standardized to Norwood 3-4 participants. So, it’s a bit disingenuous to make comparisons across studies for response rates and side effects. In other words, please take our above analysis with a grain of salt.

With that said, with different age and/or hair loss severity across studies, we can get more granular data on who tends to respond well to oral minoxidil.

Based on the above studies (and others we looked into for our analysis), the trend aligned with intuition: if you don’t have severe hair loss, you can get away with lower dosages of oral minoxidil. If you do have severe hair loss, you’ll need a higher dose.

In other words:

• If you have mild male pattern baldness, 0.25mg daily might work fine as a starting point
• A more moderate case of hair loss might require a dose of 1-2.5mg daily
• If you have severe male pattern baldness, you’re probably going to need closer to 5mg daily
• If other treatments haven’t worked for you (resistant hair loss), you may also need a higher daily dose (2.5-5mg) or combination treatments with finasteride

Then again, higher doses come with more side effects. This is where dosing gets hyper-specific.

#3: If you’re going to try oral minoxidil, you’ll need to work with a doctor to figure out your unique risk profile and the right dose

Oral minoxidil is an antihypertensive drug (lowers blood pressure). It can also cause fluid retention. Therefore, if your health history indicates problems surrounding low blood pressure, fainting spells, or edema (swelling), you may be at a higher risk of complications from taking the drug.

Moreover, oral minoxidil can stimulate hair growth everywhere… not just on the scalp. For some men, this may be a bonus. For others, it might be a drawback. If this is a drawback for you, then it’s worth noting that reports of increased body / facial hair even occurred at lower dosages (0.25 mg) of oral minoxidil. So, if you’re concerned about this, maybe oral minoxidil isn’t right for you.

Long-tory short: for the safest and most effective use of oral minoxidil, discuss your medical history and preferences with your doctor. Then convince him or her to prescribe you oral minoxidil.

Note: a dermatologist specializing in hair loss is much more likely to write you a prescription. So, if you don’t want to waste any time, make a list of dermatologists in your area, call them to see if they’re open to prescribing oral minoxidil, and then only visit the ones who prescribe the drug.

#4: Like topical minoxidil, oral minoxidil likely works better alongside other treatments

When it comes to treating pattern hair loss, combination treatments tend to almost always outperform mono-treatments.

In some cases, combination therapies allow us to use the lowest dose of a drug possible without sacrificing results. Some studies suggest this is the case for women with pattern hair loss who take 0.25mg of oral minoxidil + 25mg of spironolactone: they minimize the risk of side effects of either drug while getting hair regrowth that often exceeds that of high dosages of either drug.

In other cases, combination therapies can actually enhance the efficacy of drugs. This tends to be true of men taking topical minoxidil, and who then add in once-weekly microneedling, thereby making topical minoxidil 400% more effective (according to some investigation groups). ^[5]English RS Jr, Ruiz S, DoAmaral P. Microneedling and Its Use in Hair Loss Disorders: A Systematic Review. Dermatol Ther (Heidelb). 2022 Jan;12(1):41-60. doi: 10.1007/s13555-021-00653-2. Epub 2021 Dec … Continue reading

While there aren’t many studies that exhaustively explore this relationship for oral minoxidil, the odds are that this medication also works better as a combination therapy. So, if you’re going to commit to oral minoxidil, consider stacking it with other therapies.

Again, research here is limited, but there are a host of things you can try in combination with oral minoxidil that might increase results.

• DHT reducers (finasteride, saw palmetto, etc.)
• Microneedling
• Massage
• Ketoconazole shampoo
• Low-level laser therapy (LLLT)
• Platelet-rich plasma therapy (PRP)

…and more.

The bottom line

When it comes to oral minoxidil, the best daily dosage for men with pattern hair loss may vary depending on(1) your tolerance for certain side effects, and (2) your severity of hair loss. Consider these recommendations a mere starting point until more research emerges:

• Men with mild AGA, men at a higher risk of complication, or men who don’t want extra hair growth on their body/face: 0.25-1mg.
• Men with moderate AGA: 1-2.5mg.
• Men with resistant AGA (you’ve tried other treatments and they haven’t worked) or severe AGA: 2.5-5mg.

Although these guidelines are a rough ballpark, chances are you fit into one of these categories and, with the help of a doctor, can find the best oral minoxidil dosage for you.

Questions? Comments? Please reach out in the comments section.

Vitamin B1 – also known as thiamin (or thiamine) – is part of the B-vitamin complex. Marketers claim that vitamin B1 can help support healthy hair growth, reduce hair shedding, and even prevent hair loss. Then again, marketers also make the same claims about B-vitamins like biotin, niacin, and vitamin B12. And typically, the claims are just plain wrong.

So, is vitamin B1 any different? In this article, we’ll dive into the evidence (and answers).

First, we’ll uncover why some people that vitamin B1 helps support hair growth. Then, we’ll dive into the evidence on the vitamin B1 / thiamin-hair loss connection. Finally, we’ll dive into evidence that might implicate vitamin B1 as an accelerator of hair loss… and steps to take if you suspect you’re deficient.

By the end, you’ll have a better idea of whether vitamin B1 is a worthy investment for your hair, or just another marketing gimmick. If you have any questions or comments, please post them below!

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What is Vitamin B1?

Vitamin B1 (also thiamin or thiamine), is one of the many members of the B vitamin family.  

Vitamin B1/thiamine

Researchers first identified this essential micronutrient through the study of beri beri, a serious disease of the nervous system that was common in South East Asia prior to the 1900s.

Unlike most diseases in that time, beri beri was much more common among wealthy citizens than it was among poorer citizens. Upon further investigation, researchers found the reason for the perplexing discrepancy was actually attributed to the differences in rice consumption. 

While poorer individuals tended to consume brown rice, richer individuals tended to consume milled white rice — devoid of the husks, bran, and germ.

Through experimentation with this brown rice, a Polish biochemist, Casmir Funk, was able to isolate the compound that prevented beri beri. This compound? He termed it thiamine, meaning sulfur-containing amine — what we now know as vitamin B1.

Fast forward to today: we now know that vitamin B1 plays a crucial role in mitochondrial health, metabolism of macronutrients, and energy production — processes that are essential for the normal functioning of almost every cell in the body (1).

But, beyond the prevention of serious neurological conditions, does vitamin B1 have any benefit to our hair? 

Let’s explore the evidence.

Vitamin B1: might it help support hair growth?

There’s no doubt that vitamin B1 is critical for important processes, like (1):

• The production of ATP, the energy molecule that fuels cellular activity
• The synthesis of amino acids
• The creation of NADPH, a co-factor necessary for steroid hormone production, fatty acid synthesis, and more.

And similar to other B-complex vitamins, vitamin B1’s role in these processes often form the basis of the claim that vitamin B1 can influence hair loss. After all, if you can’t produce amino acids — the raw material our hair is actually made of — how can you grow hair?

But, is this actually true? Are there any other ways that B1 might influence our hair? And what does this mean in the context of diet in the developed world?

Let’s explore the evidence.

Does a thiamine / vitamin B1 deficiency cause hair loss?

Maybe. But this isn’t the right question to ask. Rather, we need to ask this question in two parts:

1. Does a vitamin B1 deficiency cause hair loss?
2. Does a vitamin B1 deficiency within realistic parameters cause hair loss?

Why would we do this? Because at the extremes, almost anything causes hair loss. For instance, a “water deficiency” can cause hair loss. If we don’t drink water, we die. If we’re dead, we can’t grow hair. But that doesn’t mean that drinking water will regrow our hair. It also doesn’t mean we should warn people that hair loss is a side effect of a water deficiency.

The truth is that these types of logic leaps are what marketers use to claim that deficiencies in selenium, vitamin E, and iodine can all cause hair loss. Yes, this is true – but only if our scope of deficiency includes the endpoints: malnourished poverty-stricken children, people with genetic disorders who can’t absorb these nutrients, and people with certain chronic conditions that make nutrient assimilation nearly impossible.

All this is to say that we should ask if a thiamine deficiency, in the absolutes, causes hair loss. But the better question is: does a thiamine / vitamin B1 deficiency within realistic parameters cause hair loss, too?

Let’s take these one-by-one.

1. Does a thiamine deficiency, at the extremes, cause hair loss?

Maybe (in rodent models).

This 1968 study (2) sought to determine what happens in mice fed a diet that rapidly induces a thiamine deficiency. After two and a half weeks, some mice began to experience rapid weight loss, followed by abnormal hair shedding. Soon thereafter, neurological function began to decline. After four weeks, the mice were confused and could barely walk – symptoms similar to those seen in humans with beri beri.

However, it was unclear if the hair loss was caused by the vitamin B1 deficiency or the rapid weight loss.

2. Does a thiamine deficiency, within realistic parameters, cause hair loss?

Probably not.

For starters, people with beri beri rarely reported hair shedding (even despite their rapid weight loss). Moreover, when we expand our scope to human studies, we haven’t found any hard evidence that causally links a vitamin B1 deficiency to hair loss.

We could close the case right there, and say the article is done. At the same time, the absence of evidence doesn’t always imply evidence of absence.

For instance, there’s always the possibility that vitamin B1 might exacerbate certain chronic conditions linked to hair loss, or certain disease states associated with shedding disorders.

In fact, we could assert that since a vitamin B1 deficiency can lead to rapid neurological decline and thereby weight loss, and because rapid weight loss can trigger excessive (but temporary) hair shedding, then vitamin B1 deficiencies might be indirectly related to hair loss. The deficiency causes the weight loss; the weight loss causes the hair loss.

But again, if you’re so deficient in vitamin B1 that you start losing weight, you’ve got bigger things to worry about than your hair (like rapid impending neurological deterioration).

So, do we see any other circumstances where vitamin B1 is indirectly linked to hair shedding or hair loss?

Potentially. We can find them by look at the role of vitamin B1 in the body, and then comparing this to how different types of hair loss actually develop.

Vitamin B1 deficiency may exacerbate autoimmunity

At present time, there have been several animal studies conducted to investigate a link between vitamin B1 and autoimmunity. In general, these studies have suggested that vitamin B1 deficiencies may exacerbate autoimmunity in certain autoimmune disorders – specifically, multiple sclerosis (3, 4). It stands to reason that improving vitamin B1 deficiency may also improve these autoimmune conditions.

So, how could these effects translate to hair loss?

There are several forms of hair loss that seem to be mediated by autoimmune processes. These include alopecia areata as well as some forms of scarring alopecia.

If thiamine deficiencies happened to exacerbate the autoimmune processes involved in these hair loss disorders, it’s possible that restoring thiamine levels could improve these conditions.

Again, there’s no evidence that vitamin B1 deficiency is related to these hair-related autoimmune conditions. And while all autoimmune conditions involve autoimmune processes, not all autoimmune conditions develop in the same way. Thus, we can’t necessarily extrapolate the results from the animal studies, which primarily looked at multiple sclerosis, to the autoimmune conditions that lead to hair loss.

There’s also another point to consider: the effects of certain compounds reflected in animal studies are also traditionally very difficult to extrapolate to humans. Take our rodent study from earlier: thiamin-deficient rodents developed weight loss, neurological decline, and hair loss; whereas humans with beri beri – a sign of a thiamin deficiency – typically only develop weight loss and neurological decline.

That leaves us with one last piece of evidence to consider when it comes to linking autoimmune hair loss to vitamin B1: a case series on three human patients with autoimmune thyroid conditions (5).

Vitamin B1, autoimmune thyroid disorders, and hair shedding: a possible connection?

Autoimmune conditions that affect the thyroid – like Graves’ disease and Hashimoto’s thyroiditis – can have a domino effect on hair growth which is, in part, controlled by thyroid hormones. When these hormones get too high (i.e., Graves’ disease) or too low (i.e., Hashimoto’s thyroiditis), it can cause telogen effluvium – a form of diffuse hair shedding.

Interestingly, vitamin B1 might have relevance here, especially in the context of Hashimoto’s thyroiditis.

In one case series, doctors administered vitamin B1 to three patients with Hashimoto’s thyroiditis. They hypothesized that vitamin B1 could help relieve one of the hallmark symptoms of low thyroid hormone: fatigue. 

Amazingly, that’s exactly what vitamin B1 did. In just a few hours to a few days, administration of B1 drastically improved the patients’ fatigue. 

But, this wasn’t because of a subsequent improvement in the underlying autoimmune condition.

Instead, the authors hypothesized that the autoimmune processes involved in Hashimoto’s thyroiditis may have resulted in a vitamin B1 deficiency, subsequently leading to a reduction in energy production and, thus, fatigue.

In other words, the vitamin B1 deficiency likely isn’t a contributor to the development of Hashimoto’s thyroiditis. Instead, vitamin B1 deficiency, in this case, is a consequence of the condition.

As such, we can’t expect vitamin B1 to actually improve Hashimoto’s thyroiditis or the hair loss that occurs as a result. Instead, vitamin B1 can only improve symptoms related to a vitamin B1 deficiency that may occur alongside the condition.

So, we’ve established that vitamin B1 may or may not improve autoimmune forms of hair loss. We’ve also ruled out vitamin B1 as a means to improve Hashimoto’s thyroiditis and the hair shedding that ensues as a result.

But, are there any other pathways by which B1 might influence hair loss? Maybe… and that leads us to point number two.

Vitamin B1 deficiency may impair glutathione synthesis

Glutathione is a sulfur-containing compound with powerful antioxidant activity. Unlike antioxidants we consume in our diet (like polyphenols in green tea, berries, and other health-promoting foods), glutathione is manufactured by our own cells from amino acids like cysteine, glycine, and glutamic acid. This process requires NADPH, which requires vitamin B1 (along with various other B vitamins) (6).

So, how does this relate to hair loss?

Glutathione deficiency is associated with many conditions including diabetes, cardiovascular disease, as well as autoimmune diseases (7). Some studies also show low glutathione is associated with androgenic alopecia (AGA) (8).

As an anti-inflammatory agent, it’s possible that glutathione deficiency could exacerbate the microinflammation in AGA follicles — a process that drives the hair loss observed in AGA (7, 9). 

In this context, it’s possible that through a possible increase in glutathione, vitamin B1 could reduce inflammation in AGA and, thus, improve AGA.

But there’s a difference between possible and plausible. Yes, if we stretch our imagination, it’s possible that a vitamin B1 deficiency might decrease glutathione production, and that if enough of this occurs in balding hair follicle sites, this decrease might exacerbate inflammation in AGA.

Possible, yes. But plausible?

Probably not.

While B1 deficiency seems to be related to low glutathione levels, vitamin B1 deficiency is extremely rare amongst most of the population. So, in this context, vitamin B1 is probably not something that most AGA patients need to worry about.

In these cases, glutathione deficiency is more likely to be related to co-morbidities seen in AGA: conditions like diabetes, obesity, and cardiovascular disease (all of which we know can deplete glutathione) (10).

So, while vitamin B1 deficiency could, technically, lead to or exacerbate a glutathione deficiency, it’s safe to say this is probably not the case for most AGA patients with low glutathione.

A quick recap

So far, we’ve established that B1 is an essential micronutrient. We’ve also established that in its complete absence, it can cause hair loss in rodents. Aside from that, it doesn’t appear that a vitamin B1 deficiency is a major driver of hair loss in humans.

The reason for this is three-fold: 

• Vitamin B1 deficiency is extremely uncommon in the general hair loss population.
• In the rare cases where vitamin B1 levels are depleted and associated with hair loss, improving vitamin B1 levels only improves symptoms associated with vitamin B1 depletion. In other words, vitamin B1 improves nervous system abnormalities like fatigue but not the underlying conditions that lead to hair loss.
• When looking at the relationship between vitamin B1, glutathione, and AGA, it’s unlikely that vitamin B1 deficiency contributes to low glutathione levels that may exacerbate hair loss. Rather, low glutathione levels observed in some patients appear to be a consequence of some common co-morbidities associated with AGA. 

So, that leads us to this conclusion: in the overwhelming majority of cases, vitamin B1 is not likely to confer any benefit in hair loss.

This leaves us with one last question worth asking before we close the books on the vitamin B1-hair health connection…

Could increasing vitamin B1 levels beyond normal levels have any negative effect on hair loss?

Maybe, maybe not. Let’s look at the research.

Why vitamin B1 might be bad for hair: the NADPH-DHT connection

Vitamin B1 is an essential cofactor in the production of the molecule, NADPH.

NADPH – or nicotinamide adenine dinucleotide phosphate – is a cofactor for enzymatic reactions. In other words, it’s a molecule that helps kickstart processes in the body. Earlier we established that NADPH was crucial for glutathione production. But that’s not all that NADPH does. NADPH is also essential for the production of steroid hormones.

Specifically, NADPH is a key molecule of the enzymatic process that converts testosterone into dihydrotestosterone, or DHT. Without NADPH, the enzyme that performs this conversion cannot function (11).

So, what does this mean for hair?

If you’ve done any research into androgenic alopecia (AGA), you probably already know that DHT is a significant contributor to the development of pattern hair loss (12). As such, any increase in DHT conversion could potentially worsen or speed up the balding process.

But, this would require NADPH to increase beyond what’s considered “physiological” — or what’s considered normal. So, does vitamin B1 do this?

Probably not. But we just don’t know.

What we do know is that, oftentimes, enzymes that produce molecules like NADPH have negative feedback mechanisms in place. This means that when their end-products increase, the body automatically reduces the activity of the enzymes that produce them. The net product is no increase in production.

However, this isn’t always the case. In some cases, these negative feedback loops are dysfunctional.

So, it’s possible that vitamin B1 doesn’t increase NADPH beyond what’s considered normal. As such, it’s also possible that vitamin B1 has no impact on DHT levels. At the same time, it’s also possible that it could.

In either case, the solution is the same: leverage diet to ensure vitamin B1 sufficiency and address a vitamin B1 deficiency if it’s present — but don’t go overboard.

If we’re deficient in B1, what should we do?

It’s important to note that an overwhelming majority of individuals likely aren’t deficient in vitamin B1. But, that doesn’t mean it’s impossible. Of the small pool of individuals B1 deficiency seems to affect in the modern world, risk factors appear to be:

• Hashimoto’s thyroiditis (5)
• Gastric bypass surgery (13)
• Anorexia (13)
• Severe crash dieting (13)
• Marked impairments in nutrient absorption, as in severe inflammatory bowel disease (13)
• Alcoholism (13)
• Septic shock (14)

But, again, it’s important to underscore that, even in these cases, we shouldn’t expect vitamin B1 to regrow our hair. This is because a vitamin B1 insufficiency is highly likely to present alongside other contributors to hair loss – like low thyroid hormone, zinc deficiency, iron deficiency, and severe calorie deficit. So, an improvement in B1 levels alone isn’t going to override these other factors. If anything, the thiamine deficiency-hair loss connection is more association than it is causation.

In any case, maintaining sufficient vitamin B1 levels is essential for overall health. So, you should aim to hit the recommended daily intake (RDI) everyday.

The good news is that you’re probably already doing this without even thinking about it – especially with all of the B-complex fortified foods out there. And if you find yourself falling into any of the risk categories, it’s not hard to find a supplement containing thiamine; nearly every multivitamin includes it as an ingredient.

At the same time, there could be a small minority of B1 deficiencies that go undetected, as was the case with the case series of Hashimoto’s thyroiditis patients. So, if you find yourself with fatigue that isn’t responding to standard treatment for Hashimoto’s thyroiditis, it may be worth discussing the possibility of vitamin B1 supplementation with your doctor.

Summary 

Vitamin B1 is an essential vitamin. It ensures our body can effectively produce amino acids, glutathione, and other cofactors that are crucial for cellular function.

Deficiencies in vitamin B1 have been linked to weight loss, neurological decline, and hair loss in rodents. In humans, the evidence points more so toward neurological decline and weight loss than it does hair shedding. Having said that, a vitamin B1 deficiency might indirectly exacerbate hair loss through:

1. Rapid weight loss
2. Autoimmunity
3. Glutathione impairment

But the bottom line is this: if your thiamine / vitamin B1 levels are low enough to associate with hair loss, you’ve got bigger problems than hair… like mental debilitation, neurological deterioration, and impending death.

Needless to say, 99.9% of us probably don’t need to be supplementing with vitamin B1 as a hair loss preventive. In fact, given vitamin B1’s relationship to NADPH production, and NADPH’s relationship to DHT, we could make a similar logic-leap argument that too much vitamin B1 may exacerbate hair loss.

This leaves us with one firm conclusion: maintain sufficient vitamin B1 levels by consuming the recommended daily intake. In the developed world, nearly every single diet will do this for you… provided you don’t have any of the hallmarks that increase your risk of a B1 deficiency (i.e., alcoholism, gastric bypass surgery, anorexia, etc.).

In the rare case that you are deficient, work with a doctor to address why your levels might be decreased in the first place and, if needed, to increase your levels with supplementation.

Have any questions about Vitamin B1 and hair health? Please leave them below in the comments!

Subscription services have gained popularity in recent years for all types of products, from home cleaning supplies to underwear, razors, and even toothpaste. These services make the most sense for products used consistently, saving the consumer time and money. Hair regrowth treatments certainly meet the criteria. For the most part, they only work as long as you keep using them. So, it was only a matter of time before startups put men’s hair care on autopay. 

Of the telemedicine providers focusing on men’s health, Hims, Keeps and Roman have risen to the top of  this competitive market. But which one is best? We offer an objective side-by-side comparison of these 3 hair loss subscription companies. In the process, you’ll learn about the following:

• About the Products Sold
• What Differentiates the Providers
• Why Choose One Over The Other

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*Only available in the U.S. Prescriptions not guaranteed. Restrictions apply. Off-label products are not endorsed by the FDA.

About the Products

Hims, Keeps, and Roman all offer the same hair regrowth products, namely Finasteride and Minoxidil. These are the only two medications approved by the FDA to treat androgenic alopecia (AGA), or male pattern baldness.

Finasteride

Finasteride, also known by the brand name Propecia, is one of the most well studied, and most powerful, drug for AGA.  The daily pill stops the progression of hair loss in 80-90% of men and, on average, leads to a 10% increase in hair count over two years.^[1]https://www.sciencedirect.com/science/article/pii/S0022202X15529357​​

Oral finasteride is an FDA-approved treatment for AGA that inhibits the enzyme type II 5-alpha reductase, and thereby reduces dihydrotestosterone (DHT) levels in the body. While it’s effective in slowing, stopping, and partially reversing AGA’s progression, some men can experience side effects associated with the systemic reduction in DHT levels.

Topical Finasteride aims to avoid such side effects by localizing the drug’s effects to the scalp. Research on topical finasteride is still in its infancy, but the drug does appear to be effective for lowering DHT in the scalp. Real world results vary widely in part because method of delivery, dilution ratios and carrier agents (non-active ingredients) used to deliver the drug, also vary widely. 

Minoxidil

Minoxidil, also known by the brand name Rogain, is the other FDA-approved drug for the treatment of AGA. Although available orally, it’s most popular as a topical. Over half of those who try topical minoxidil respond to the drug within 3-6 months. Of those, research reports hair count increases of up to 12% over 48 weeks.^[2]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691938/

Among the downsides of Minoxidil is that the treatment’s effectiveness does wane over time. When that happens, those who quit tend to lose any and all gains they had from the drug, ending up back where they started before ever having used it.

Having Trouble Separating Follicle Facts from Fiction?

One reason why Minoxidil’s effectiveness might taper is that it doesn’t address hair follicle miniaturization. So, while it does increase hair counts by kicking hair back into the growth cycle, hair continues to thin over time.

When combined with additional therapies, however, most if not all of these downsides can be mitigated. Minoxidil may work better when combined with scalp exfoliators such as retinol or retinoic acid. Research also finds minoxidil is up to four times more effective when combined with microneedling.^[3]http://www.ijtrichology.com/article.asp?issn=0974-7753;year=2013;volume=5;issue=1;spage=6;epage=11;aulast=Dhurat

The effectiveness of Minoxidil may be best when used with Finasteride. These two treatment options can be combined. 

• Minoxidil Response rate: 30-40% alone; 70+% if combined with microneedling and/or finasteride
• Minoxidil Regrowth rate: ~10% alone; 25-40% if combined with microneedling and/or finasteride

Both Finasteride and Minoxidil require ongoing, daily application for results maintenance. Hence, the appeal of subscription services. So let’s take a closer look at the three biggest players offering Finasteride and Minoxidil online.

Hims vs Keeps vs Roman 

Hims, Keeps and Roman are telemedicine providers who, after a phone or video consultation, provide prescriptions for hair loss treatments. Products are shipped discreetly to the buyer’s home, with savings available for ongoing, subscription-based delivery.

Hims 

Hims brands themselves as ‘all about personal wellness.’ The company offers products not only for hair loss, but also for men’s sexual health. They sell both prescription-based and over-the-counter solutions.

Roman

Roman is the men’s health wing of Ro.co, a consumer healthcare company with a mission to make healthcare accessible and convenient. The digital healthcare provider wants to make it easier for more men to seek preventative care. Of these 3 companies, they treat the widest range of men’s health conditions.

Keeps

Keeps focuses only on treating hair loss, versus general men’s health. Founded in 2018, the company aims to ‘help more men keep more hair.’ In addition to selling prescription treatments and hair care products, Keeps will link clients to hair restoration surgeons.

Each of the above companies sells generic Finasteride and Minoxidil, but the products differ slightly between sites. Below is a closer look at what’s on offer. 

Subscription-Based Hair Loss Products

Hims Products 

Of the 3 providers, Hims sells the greatest variety of products and hair treatment packages. The Hair Power Pack includes a combination of oral finasteride and 5% Minoxidil, plus Biotin gummies and a thickening shampoo. 

Hims is also the only of the three companies to offer a topical Finasteride. The topical combines 0.3% finasteride with 6% Minoxidil. Active ingredients are diluted in alcohol (ethanol), propylene glycol and citric acid and delivered via spray bottle.

Propylene glycol as a carrier does lead to skin irritation in up to 6% of users, although this is considered a very mild side effect.^[4]https://pubchem.ncbi.nlm.nih.gov/compound/Propylene-glycol

Keeps Products

Keeps does not offer a topical finasteride, but does include options for either foam or serum-based Minoxidil just as Hims does. They are also the only provider to sell a 2% ketoconazole shampoo. Alongside finasteride and minoxidil, ketoconazole is considered one of the “big three” treatment options for pattern hair loss.

Despite its popularity, however, ketoconazole is not actually FDA-approved for pattern hair loss, nor is it as well-researched as minoxidil or finasteride. However, the low-cost, low-effort treatment (used 2-3 times per week) seems to carry little (if any) risk of side effects.

Roman Products

Roman is the biggest generalist of the companies we’re comparing here. Hair loss is not necessarily their primary focus and they have the least number of hair-related products on offer. Roman offers oral finasteride, a Propecia generic made by Ascend in India, as well as a solution-based Minoxidil made by Pure Source, LLC. They do not offer a foam-based Minoxidil as Hims and Keeps do.

The Subscription & Cost

Topical minoxidil is an over-the-counter product and can be purchased directly without a telemedicine consult. Finasteride, whether oral or topical, and 2% ketoconazole do, however, require a prescription. How this process works differs slightly between Roman, Hims and Keeps.

The Hims Consultation Process

Hims begins with a free online consultation that includes a few personal questions, and offers quick access to a licensed medical provider, in all 50 states. Subscribed medications are then filled at a licensed pharmacy, and shipped to you directly. 

Shipping info and billing frequency??

The Keeps Process

Keeps also begins with a free online consultation. After answering a few questions online, Keeps requires an upload of photos, which are then reviewed by a licensed provider. Treatments are shipped every 3, 6 or 12 months.  Continued on-demand access to a live medical professional is available via their app for $10/month.

The Roman Process

Like the rest, Roman’s process begins with a free online visit. Depending on the state, a phone or video chat with a doctor or nurse practitioner may be required. Prescriptions are filled via the Ro Pharmacy Network, and shipped directly in discreet packaging. Roman offers free, unlimited follow-ups if needed. Prescriptions are available in monthly or quarterly auto-shipments.

Cost Comparison

Pros and Cons

Whether Roman, Hims, or Keeps is best is a personal decision that depends on the treatment sought, any extra over-the-counter shampoos, vitamins or other add-ons desired, and what state the patient lives in. 

Hims Pros & Cons

Of the three companies in our comparison, Hims offers the most treatment options and is the only one to offer topical finasteride. Topical finasteride is also available from the following, lesser known companies:

• Happy Head: 0.25% Finasteride + 8% Minoxidil 8% + 0.01% Retinoic Acid + 1% Hydrocortisone. The formula is customizable and available for $79+/month
• Strut: Strut offers a customizable gel or solution-based topical with the following options, Finasteride 0.1-0.25%, Minoxidil 0.0%-7.5%, Tretinoin 0.0%-0.0125%, available starting at $59/month

On the other hand, Hims also ranks as the most expensive for either Finasteride or Minoxidil.

Keeps Pros & Cons

Keeps is the only provider on our list to offer Ketoconazole shampoo. So for those interested in trying the ‘Big 3’ protocol for hair loss, Keeps is a good bet. It’s also the least expensive provider of Finasteride and Minoxidil.

The main drawback of Keeps is that it’s not yet available in every state. They can, however, fill prescriptions in every state. So if you have a prescription from another doctor, Keeps may be able to fill it for a lower price. 

Roman Pros & Cons

Of these 3 digital medicine providers, Roman is doing its best to position itself as a one-stop-shop for all things health-related. Contact with a licensed healthcare professional is available in every state, and you can go to Roman for nearly all things health-related.

The downside is that Roman is not focused on hair loss prevention nor hair regrowth alone, and they offer the most limited treatments options out of the 3 on our list.

Summary

Roman, Hims, and Keeps are all telemedicine providers who have risen to the top of the competitive men’s wellness market in part due to their focus on hair loss prevention and treatment.

Each company focuses primarily on oral finasteride and topical (OTC) minoxidil and will prescribe the former after a brief online consultation. 

Subscription services and products vary. Which is best may depend on the state the patient lives in, and exactly which treatments are being sought.