- About
- Mission Statement
Education. Evidence. Regrowth.
- Education.
Prioritize knowledge. Make better choices.
- Evidence.
Sort good studies from the bad.
- Regrowth.
Get bigger hair gains.
Team MembersPhD's, resarchers, & consumer advocates.
- Rob English
Founder, researcher, & consumer advocate
- Research Team
Our team of PhD’s, researchers, & more
Editorial PolicyDiscover how we conduct our research.
ContactHave questions? Contact us.
Before-Afters- Transformation Photos
Our library of before-after photos.
- — Jenna, 31, U.S.A.
I have attached my before and afters of my progress since joining this group...
- — Tom, 30, U.K.
I’m convinced I’ve recovered to probably the hairline I had 3 years ago. Super stoked…
- — Rabih, 30’s, U.S.A.
My friends actually told me, “Your hairline improved. Your hair looks thicker...
- — RDB, 35, New York, U.S.A.
I also feel my hair has a different texture to it now…
- — Aayush, 20’s, Boston, MA
Firstly thank you for your work in this field. I am immensely grateful that...
- — Ben M., U.S.A
I just wanted to thank you for all your research, for introducing me to this method...
- — Raul, 50, Spain
To be honest I am having fun with all this and I still don’t know how much...
- — Lisa, 52, U.S.
I see a massive amount of regrowth that is all less than about 8 cm long...
Client Testimonials150+ member experiences.
Scroll DownPopular Treatments- Treatments
Popular treatments. But do they work?
- Finasteride
- Oral
- Topical
- Dutasteride
- Oral
- Topical
- Mesotherapy
- Minoxidil
- Oral
- Topical
- Ketoconazole
- Shampoo
- Topical
- Low-Level Laser Therapy
- Therapy
- Microneedling
- Therapy
- Platelet-Rich Plasma Therapy (PRP)
- Therapy
- Scalp Massages
- Therapy
- More
IngredientsTop-selling ingredients, quantified.
- Saw Palmetto
- Redensyl
- Melatonin
- Caffeine
- Biotin
- Rosemary Oil
- Lilac Stem Cells
- Hydrolyzed Wheat Protein
- Sodium Lauryl Sulfate
- More
ProductsThe truth about hair loss "best sellers".
- Minoxidil Tablets
Xyon Health
- Finasteride
Strut Health
- Hair Growth Supplements
Happy Head
- REVITA Tablets for Hair Growth Support
DS Laboratories
- FoliGROWTH Ultimate Hair Neutraceutical
Advanced Trichology
- Enhance Hair Density Serum
Fully Vital
- Topical Finasteride and Minoxidil
Xyon Health
- HairOmega Foaming Hair Growth Serum
DrFormulas
- Bio-Cleansing Shampoo
Revivogen MD
- more
Key MetricsStandardized rubrics to evaluate all treatments.
- Evidence Quality
Is this treatment well studied?
- Regrowth Potential
How much regrowth can you expect?
- Long-Term Viability
Is this treatment safe & sustainable?
Free Research- Free Resources
Apps, tools, guides, freebies, & more.
- Free CalculatorTopical Finasteride Calculator
- Free Interactive GuideInteractive Guide: What Causes Hair Loss?
- Free ResourceFree Guide: Standardized Scalp Massages
- Free Course7-Day Hair Loss Email Course
- Free DatabaseIngredients Database
- Free Interactive GuideInteractive Guide: Hair Loss Disorders
- Free DatabaseTreatment Guides
- Free Lab TestsProduct Lab Tests: Purity & Potency
- Free Video & Write-upEvidence Quality Masterclass
- Free Interactive GuideDermatology Appointment Guide
- More
Articles100+ free articles.
-
Genetic Tests: A Breakthrough for Personalized Hair Loss Treatments?
-
Do Chinese Herbs Help Regrow Hair? A Look At Traditional Remedies
-
Cannabidiol (CBD) Increases Hair Counts By 246%? Not So Fast.
-
Creatine: Does It Worsen Hair Loss? It Depends On The Hair Loss Type.
-
Can Progesterone Improve Hair Regrowth?
-
CRABP2: Can This Gene Predict Regrowth From Retinoids?
-
BTD: Can This Gene Predict Regrowth From Biotin?
-
COL1A1: Can This Gene Predict Regrowth From Collagen Support?
PublicationsOur team’s peer-reviewed studies.
- Microneedling and Its Use in Hair Loss Disorders: A Systematic Review
- Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review
- Conflicting Reports Regarding the Histopathological Features of Androgenic Alopecia
- Self-Assessments of Standardized Scalp Massages for Androgenic Alopecia: Survey Results
- A Hypothetical Pathogenesis Model For Androgenic Alopecia:Clarifying The Dihydrotestosterone Paradox And Rate-Limiting Recovery Factors
Menu- AboutAbout
- Mission Statement
Education. Evidence. Regrowth.
- Team Members
PhD's, resarchers, & consumer advocates.
- Editorial Policy
Discover how we conduct our research.
- Contact
Have questions? Contact us.
- Before-Afters
Before-Afters- Transformation Photos
Our library of before-after photos.
- Client Testimonials
Read the experiences of members
Before-Afters/ Client Testimonials- Popular Treatments
-
TreatmentsOral Finasteride
Evidence99%RegrowthViabilityTopical Finasteride
Evidence69%RegrowthViabilityMesotherapy Finasteride
Evidence28%RegrowthViability-
Oral
-
Topical
-
Mesotherapy
-
Evidence Quality
99%
Regrowth Potential
Long-Term Viability
Written by Perfect Hair Health TeamMedically Reviewed by Rob EnglishFirst Published Oct 1, 2024Last Updated Oct 23, 2024Key Information
Free Resources
KEY INFORMATIONWhat is Finasteride?
Finasteride is a drug that lowers dihydrotestosterone (DHT) – a hormone causally linked to androgenic alopecia. Oral finasteride is FDA-approved treatment for androgenic alopecia. It is available in oral, topical, and mesotherapy formulations.
How does Finasteride work?
Finasteride lowers DHT by inhibiting an enzyme called type II 5-alpha reductase. At daily doses of 0.2 to 5.0 mg, finasteride can lower DHT by as much as 70%.
What you should know
Oral finasteride is FDA-approved and is currently the best-studied drug for treating androgenic alopecia. While oral finasteride does come with a risk of sexual side effects, these risks can be mitigated and (sometimes) eliminated by trying lower doses and/or topical formulations.
-
Evidence Quality
69%
Regrowth Potential
Long-Term Viability
Written by Perfect Hair Health TeamMedically Reviewed by Rob EnglishFirst Published Oct 1, 2024Last Updated Oct 23, 2024Key Information
Free Resources
KEY INFORMATIONWhat is Finasteride?
Finasteride is a drug that lowers dihydrotestosterone (DHT) – a hormone causally linked to androgenic alopecia. Oral finasteride is FDA-approved treatment for androgenic alopecia. It is available in oral, topical, and mesotherapy formulations.
How does Finasteride work?
Finasteride lowers DHT by inhibiting an enzyme called type II 5-alpha reductase. At daily doses of 0.2 to 5.0 mg, finasteride can lower DHT by as much as 70%.
What you should know
Oral finasteride is FDA-approved and is currently the best-studied drug for treating androgenic alopecia. While oral finasteride does come with a risk of sexual side effects, these risks can be mitigated and (sometimes) eliminated by trying lower doses and/or topical formulations.
-
Evidence Quality
28%
Regrowth Potential
Long-Term Viability
Written by Perfect Hair Health TeamMedically Reviewed by Rob EnglishFirst Published Oct 1, 2024Last Updated Oct 23, 2024Key Information
Free Resources
KEY INFORMATIONWhat is Finasteride?
Finasteride is a drug that lowers dihydrotestosterone (DHT) – a hormone causally linked to androgenic alopecia. Oral finasteride is FDA-approved treatment for androgenic alopecia. It is available in oral, topical, and mesotherapy formulations.
How does Finasteride work?
Finasteride lowers DHT by inhibiting an enzyme called type II 5-alpha reductase. At daily doses of 0.2 to 5.0 mg, finasteride can lower DHT by as much as 70%.
What you should know
Oral finasteride is FDA-approved and is currently the best-studied drug for treating androgenic alopecia. While oral finasteride does come with a risk of sexual side effects, these risks can be mitigated and (sometimes) eliminated by trying lower doses and/or topical formulations.
FREE RESOURCESArticles
Explore the science behind hair loss and hair growth. Our in-depth articles cover topics ranging from natural remedies to pharmaceuticals to breakthroughs in hair loss science. Want to request an article topic? Contact us.
By Sarah King, PhDNov 21, 2024Genetic Tests: A Breakthrough for Personalized Hair Loss Treatments?
Genetic testing is trending in the hair loss industry. The premise? Our genes hold the secrets to better hair growth, and genetic testing can help hair loss sufferers unlock new levels of hair gains with customized treatments. It’s an enticing proposition, and one that holds little-to-no scien...
By Ben Fletcher, PhDAug 6, 2024SRD5A1 & 2: Can These Genes Predict Regrowth From 5-Alpha-Reductase Inhibitors?
Can your genes predict the effectiveness of 5α-reductase inhibitors for hair loss? The SRD5A1 and SRD5A2 genes, encoding type I and type II 5α-reductase respectively, are central to DHT production, a key factor in the pathogenesis of androgenic alopecia. Genetic testing companies suggest certain SR5...
By Perfect Hair Health TeamApr 19, 2024How To Identify How Fast You’re Losing Hair & Why This Matters
On average, people with androgenic alopecia lose 5% hair volume per year. However, this rate of progression is just an average; some people lose hair much faster. Those with rapidly-progressing hair loss face higher opportunity costs for treatment failures, and therefore have less opportunity to exp...
By Sarah King, PhDApr 11, 2024Is Hair Loss Treatment Lifelong? Here’s What The Data Show.
It can be daunting to think of hair loss treatments as a lifelong commitment. And for most cases of androgenic alopecia, this is true. However, starting treatment does not necessarily mean you must commit to a lifetime of treatment. Studies suggest that after stopping a hair loss treatment, hair los...
By Perfect Hair Health TeamFeb 26, 2024What Happens If I Stop Using Finasteride?
After quitting finasteride, two-year clinical studies suggest that hair loss resumes 1-3 months after withdrawal. Within 3-12 months of quitting, hair counts return to where they were prior to starting the drug, and hair loss continues. But what about those who quit finasteride temporarily? What abo...
By Perfect Hair Health TeamFeb 22, 2023How Often Do I Need To Take Oral Finasteride?
Oral finasteride is prescribed at 1 mg daily to treat androgenic alopecia (AGA). However, clinical studies suggest that doses as low as 0.2 mg daily can reduce levels of dihydrotestosterone (DHT) nearly the same as 1.0 mg daily doses, and improve hair counts similarly to 1 mg daily. But do these low...
By Perfect Hair Health TeamFeb 20, 2023How Long Does Finasteride Stay in Scalp Tissue?
Finasteride is an FDA-approved hair loss treatment, with clinical studies showing that the drug lowers levels of the hormone dihydrotestosterone (DHT) by 60-70%, and in doing so, improves outcomes of androgenic alopecia (AGA) for 80-90% of the men who try to the drug. But how long do finasterideR...
By Perfect Hair Health TeamFeb 17, 2023How Long Does Finasteride Stay in the Bloodstream?
Oral finasteride is an excellent option for men wanting a ‘hands-free’ approach to hair maintenance. However, some men decide to temporarily or discontinue use of the drug to troubleshoot side effects, conceive, or even start donating blood. Under these circumstances, how long does finasteride stay ...
By Perfect Hair Health TeamFeb 16, 2023What’s the Best Dose of Finasteride for Hair Loss?
The best daily dose of finasteride should strike the balance between minimizing drug exposure (and thereby side effect risks) while maximizing drug efficacy (and thereby hair regrowth). While the FDA has approved 1 mg daily doses of finasteride for androgenic alopecia, there’s also evidence th...
By Perfect Hair Health TeamFeb 16, 2023What Is Post-Finasteride Syndrome (PFS)? Is It Real? And What Is Its Prevalence?
Post-Finasteride Syndrome (PFS) is a term used to describe persistent sexual or cognitive side effects from finasteride, even months after quitting the medication. The existence of PFS is hotly debated amongst hair loss researchers, endocrinologists, and dermatologists. In this article, we’ll ...
By Perfect Hair Health TeamFeb 15, 2023Can I Make Topical Finasteride By Crushing Pills?
It’s possible to make homemade topical finasteride by crushing pills. However, some pills have a protective coating that may prevent them from dissolving in a topical. Under these circumstances, any coating must be removed prior to crushing, and even then, not all crushed debris will dissolve. For t...
By Perfect Hair Health TeamFeb 7, 2023If I Am Planning a Family, Should I Stop Taking Finasteride? (Men & Women)
Females using oral finasteride are advised to quit the drug at least one month before conceiving, as well as throughout pregnancy and breastfeeding. But what about men? The evidence is nuanced. Some clinicians claim that finasteride use for men during windows of conception poses no risk to a develop...
By Perfect Hair Health TeamJan 24, 2023Will Finasteride Lower My Libido?
Finasteride is widely regarded as the gold-standard treatment for male pattern hair loss, with 80-90% of men responding favorably to the drug. At the same time, the number one reason people avoid this hair loss medication is the fear of lower libido. Online reports of finasteride’s sexual side effec...
By Perfect Hair Health TeamJan 20, 2023Which Finasteride Is Best? A Look at Formulations
Finasteride is available in oral and topical formulations. Some hair loss sufferers opt for topicals, which have been touted as safe and effective by doctors and patients alike. Oral finasteride has stood the test of time and remains the gold standard for the treatment of male pattern hair loss. Whi...
By Perfect Hair Health TeamJan 15, 2023Can a Blood Test for Finasteride Determine the Risk of Side Effects?
Can blood tests reliably determine the risk of sexual side effects from hair loss drugs? Low-quality evidence (i.e., anecdotes and observational studies) suggest, in men, that low levels of free testosterone and/or high levels of sex hormone binding globulin are correlated with higher rates of sexua...
By Perfect Hair Health TeamJan 10, 2023How to Reduce the Risk of Finasteride Side Effects
Finasteride is an FDA-approved drug for androgenic alopecia. For a portion of men using finasteride, side effects can occur – most often in the form of sexual side effects, enlarged male breasts, lowered sperm counts, and erectile dysfunction. Fortunately, there are several strategies that can be em...
By Richard Clayton, PhDOct 25, 2022Finasteride For Women: What’s The Perfect Dose?
Oral finasteride is an effective treatment for male pattern hair loss, also known as androgenic alopecia. However, the drug’s benefits to female pattern hair loss are less clear. Some studies show that females taking between 1.0 to 5.0 mg of finasteride daily improve their hair loss, while oth...
By Perfect Hair Health TeamApr 16, 2022Hims vs Keeps vs Roman: Which Hair Growth Subscription Service Wins?
Hair growth subscription services are sprouting up everywhere online. Among them, three companies have emerged from the pack: Hims, Keeps, and Roman. Each company offers two FDA-approved hair loss treatments, as well as other add-on products (supplements, gummies, etc). In this post, the Perfect Hai...
By Perfect Hair Health TeamApr 6, 2022The 6 Best DHT Blockers For Men
Which DHT blockers work? Which ones put hair loss sufferers at a greater risk of side effects? What does the actual evidence say versus marketing hype for the latest DHT-reducing supplements, topicals, and drugs? The answers may surprise you. In this article, the Perfect Health Team evaluates 6 DHT ...
By Perfect Hair Health TeamJul 2, 2020Scarring Alopecias: What Makes Them Unique (And Reversible)
Scarring alopecias were once thought to be irreversible. Now, studies are proving just the opposite. Case reports are showing that people with scarring alopecias have experienced complete hair regrowth, and from changes as simple as quitting sunscreen. Read on to learn the science behind these scarr...
By Perfect Hair Health TeamJan 9, 2020Saw Palmetto: Is It As Effective As Finasteride?
Saw palmetto is less effective than finasteride for treating pattern hair loss – with clinical studies showing lower response rates and regrowth rates in men taking 320mg of saw palmetto versus 1mg of finasteride daily. However, saw palmetto is also associated with fewer sexual side effects. This me...FREE RESOURCESArticles
Explore the science behind hair loss and hair growth. Our in-depth articles cover topics ranging from natural remedies to pharmaceuticals to breakthroughs in hair loss science. Want to request an article topic? Contact us.
By Sarah King, PhDNov 21, 2024Genetic Tests: A Breakthrough for Personalized Hair Loss Treatments?
Genetic testing is trending in the hair loss industry. The premise? Our genes hold the secrets to better hair growth, and genetic testing can help hair loss sufferers unlock new levels of hair gains with customized treatments. It’s an enticing proposition, and one that holds little-to-no scien...
By Ben Fletcher, PhDAug 6, 2024SRD5A1 & 2: Can These Genes Predict Regrowth From 5-Alpha-Reductase Inhibitors?
Can your genes predict the effectiveness of 5α-reductase inhibitors for hair loss? The SRD5A1 and SRD5A2 genes, encoding type I and type II 5α-reductase respectively, are central to DHT production, a key factor in the pathogenesis of androgenic alopecia. Genetic testing companies suggest certain SR5...
By Perfect Hair Health TeamApr 19, 2024How To Identify How Fast You’re Losing Hair & Why This Matters
On average, people with androgenic alopecia lose 5% hair volume per year. However, this rate of progression is just an average; some people lose hair much faster. Those with rapidly-progressing hair loss face higher opportunity costs for treatment failures, and therefore have less opportunity to exp...
By Sarah King, PhDApr 11, 2024Is Hair Loss Treatment Lifelong? Here’s What The Data Show.
It can be daunting to think of hair loss treatments as a lifelong commitment. And for most cases of androgenic alopecia, this is true. However, starting treatment does not necessarily mean you must commit to a lifetime of treatment. Studies suggest that after stopping a hair loss treatment, hair los...
By Perfect Hair Health TeamFeb 26, 2024What Happens If I Stop Using Finasteride?
After quitting finasteride, two-year clinical studies suggest that hair loss resumes 1-3 months after withdrawal. Within 3-12 months of quitting, hair counts return to where they were prior to starting the drug, and hair loss continues. But what about those who quit finasteride temporarily? What abo...
By Perfect Hair Health TeamFeb 26, 2024Topical Finasteride: How Can I Minimize My Partner’s Exposure To The Drug?
Some topical finasteride users worry about inadvertently exposing their partner or kids to the drug – particularly if household members often touch their hair or use the same pillowcases. In most scenarios, indirect exposure to topical finasteride is not a cause for concern – particularly if users g...
By Perfect Hair Health TeamFeb 23, 2023How Often Do I Need To Apply Topical Finasteride?
Is a single daily topical finasteride application enough to significantly reduce DHT levels and regrow hair? It depends on the dilution of topical finasteride, the application volume (in mL), the carrier ingredients, how long that topical finasteride is left on the scalp prior to washing it out, and...
By Perfect Hair Health TeamFeb 20, 2023How Long Does Finasteride Stay in Scalp Tissue?
Finasteride is an FDA-approved hair loss treatment, with clinical studies showing that the drug lowers levels of the hormone dihydrotestosterone (DHT) by 60-70%, and in doing so, improves outcomes of androgenic alopecia (AGA) for 80-90% of the men who try to the drug. But how long do finasterideR...
By Perfect Hair Health TeamFeb 17, 2023How Long Does Finasteride Stay in the Bloodstream?
Oral finasteride is an excellent option for men wanting a ‘hands-free’ approach to hair maintenance. However, some men decide to temporarily or discontinue use of the drug to troubleshoot side effects, conceive, or even start donating blood. Under these circumstances, how long does finasteride stay ...
By Perfect Hair Health TeamFeb 16, 2023What Is Post-Finasteride Syndrome (PFS)? Is It Real? And What Is Its Prevalence?
Post-Finasteride Syndrome (PFS) is a term used to describe persistent sexual or cognitive side effects from finasteride, even months after quitting the medication. The existence of PFS is hotly debated amongst hair loss researchers, endocrinologists, and dermatologists. In this article, we’ll ...
By Perfect Hair Health TeamFeb 15, 2023Can I Make Topical Finasteride By Crushing Pills?
It’s possible to make homemade topical finasteride by crushing pills. However, some pills have a protective coating that may prevent them from dissolving in a topical. Under these circumstances, any coating must be removed prior to crushing, and even then, not all crushed debris will dissolve. For t...
By Perfect Hair Health TeamFeb 14, 2023Can I Make My Own Topical Finasteride?
Compounding pharmacies can charge $50-$100 per month to formulate topical finasteride. This has led many users to wonder if they can save money by making topical finasteride at home – either by crushing finasteride pills or diluting pre-purchased topical finasteride. Both options are possible, but r...
By Perfect Hair Health TeamFeb 7, 2023If I Am Planning a Family, Should I Stop Taking Finasteride? (Men & Women)
Females using oral finasteride are advised to quit the drug at least one month before conceiving, as well as throughout pregnancy and breastfeeding. But what about men? The evidence is nuanced. Some clinicians claim that finasteride use for men during windows of conception poses no risk to a develop...
By Perfect Hair Health TeamJan 24, 2023Will Finasteride Lower My Libido?
Finasteride is widely regarded as the gold-standard treatment for male pattern hair loss, with 80-90% of men responding favorably to the drug. At the same time, the number one reason people avoid this hair loss medication is the fear of lower libido. Online reports of finasteride’s sexual side effec...
By Perfect Hair Health TeamJan 20, 2023Which Finasteride Is Best? A Look at Formulations
Finasteride is available in oral and topical formulations. Some hair loss sufferers opt for topicals, which have been touted as safe and effective by doctors and patients alike. Oral finasteride has stood the test of time and remains the gold standard for the treatment of male pattern hair loss. Whi...
By Perfect Hair Health TeamJan 15, 2023Can a Blood Test for Finasteride Determine the Risk of Side Effects?
Can blood tests reliably determine the risk of sexual side effects from hair loss drugs? Low-quality evidence (i.e., anecdotes and observational studies) suggest, in men, that low levels of free testosterone and/or high levels of sex hormone binding globulin are correlated with higher rates of sexua...
By Perfect Hair Health TeamJan 10, 2023How to Reduce the Risk of Finasteride Side Effects
Finasteride is an FDA-approved drug for androgenic alopecia. For a portion of men using finasteride, side effects can occur – most often in the form of sexual side effects, enlarged male breasts, lowered sperm counts, and erectile dysfunction. Fortunately, there are several strategies that can be em...
By Richard Clayton, PhDOct 25, 2022Finasteride For Women: What’s The Perfect Dose?
Oral finasteride is an effective treatment for male pattern hair loss, also known as androgenic alopecia. However, the drug’s benefits to female pattern hair loss are less clear. Some studies show that females taking between 1.0 to 5.0 mg of finasteride daily improve their hair loss, while oth...
By Perfect Hair Health TeamSep 20, 2022How to Apply Topical Finasteride for Maximum Absorption
Topical finasteride has quickly become one of the most popular hair growth solutions, and for good reason. After all, it has been proven to inhibit the action of 5-alpha-reductase, the enzyme that induces follicle-shrinking DHT. However, as some Perfect Hair Health members have reported, instruction...
By Perfect Hair Health TeamApr 16, 2022Hims vs Keeps vs Roman: Which Hair Growth Subscription Service Wins?
Hair growth subscription services are sprouting up everywhere online. Among them, three companies have emerged from the pack: Hims, Keeps, and Roman. Each company offers two FDA-approved hair loss treatments, as well as other add-on products (supplements, gummies, etc). In this post, the Perfect Hai...
By Perfect Hair Health TeamApr 6, 2022The 6 Best DHT Blockers For Men
Which DHT blockers work? Which ones put hair loss sufferers at a greater risk of side effects? What does the actual evidence say versus marketing hype for the latest DHT-reducing supplements, topicals, and drugs? The answers may surprise you. In this article, the Perfect Health Team evaluates 6 DHT ...
By Perfect Hair Health TeamMar 21, 2022Topical Finasteride: The Best Dosage for Maximizing Regrowth and Minimizing Side Effects
Since earning FDA approval in 1997, Finasteride has been one of the most widely used hair loss drugs. To avoid potential sexual side effects, many opt for topical finasteride in hopes of isolating the drug’s DHT-reducing effects on the scalp. However, at certain doses, topical finasteride can enter ...
By Perfect Hair Health TeamJul 2, 2020Scarring Alopecias: What Makes Them Unique (And Reversible)
Scarring alopecias were once thought to be irreversible. Now, studies are proving just the opposite. Case reports are showing that people with scarring alopecias have experienced complete hair regrowth, and from changes as simple as quitting sunscreen. Read on to learn the science behind these scarr...
By Perfect Hair Health TeamJan 9, 2020Saw Palmetto: Is It As Effective As Finasteride?
Saw palmetto is less effective than finasteride for treating pattern hair loss – with clinical studies showing lower response rates and regrowth rates in men taking 320mg of saw palmetto versus 1mg of finasteride daily. However, saw palmetto is also associated with fewer sexual side effects. This me...FREE RESOURCESArticles
Explore the science behind hair loss and hair growth. Our in-depth articles cover topics ranging from natural remedies to pharmaceuticals to breakthroughs in hair loss science. Want to request an article topic? Contact us.
By Ben Fletcher, PhDAug 6, 2024SRD5A1 & 2: Can These Genes Predict Regrowth From 5-Alpha-Reductase Inhibitors?
Can your genes predict the effectiveness of 5α-reductase inhibitors for hair loss? The SRD5A1 and SRD5A2 genes, encoding type I and type II 5α-reductase respectively, are central to DHT production, a key factor in the pathogenesis of androgenic alopecia. Genetic testing companies suggest certain SR5...
By Perfect Hair Health TeamApr 19, 2024How To Identify How Fast You’re Losing Hair & Why This Matters
On average, people with androgenic alopecia lose 5% hair volume per year. However, this rate of progression is just an average; some people lose hair much faster. Those with rapidly-progressing hair loss face higher opportunity costs for treatment failures, and therefore have less opportunity to exp...
By Sarah King, PhDApr 11, 2024Is Hair Loss Treatment Lifelong? Here’s What The Data Show.
It can be daunting to think of hair loss treatments as a lifelong commitment. And for most cases of androgenic alopecia, this is true. However, starting treatment does not necessarily mean you must commit to a lifetime of treatment. Studies suggest that after stopping a hair loss treatment, hair los...
By Perfect Hair Health TeamFeb 26, 2024What Happens If I Stop Using Finasteride?
After quitting finasteride, two-year clinical studies suggest that hair loss resumes 1-3 months after withdrawal. Within 3-12 months of quitting, hair counts return to where they were prior to starting the drug, and hair loss continues. But what about those who quit finasteride temporarily? What abo...
By Perfect Hair Health TeamFeb 20, 2023How Long Does Finasteride Stay in Scalp Tissue?
Finasteride is an FDA-approved hair loss treatment, with clinical studies showing that the drug lowers levels of the hormone dihydrotestosterone (DHT) by 60-70%, and in doing so, improves outcomes of androgenic alopecia (AGA) for 80-90% of the men who try to the drug. But how long do finasterideR...
By Perfect Hair Health TeamFeb 17, 2023How Long Does Finasteride Stay in the Bloodstream?
Oral finasteride is an excellent option for men wanting a ‘hands-free’ approach to hair maintenance. However, some men decide to temporarily or discontinue use of the drug to troubleshoot side effects, conceive, or even start donating blood. Under these circumstances, how long does finasteride stay ...
By Perfect Hair Health TeamFeb 16, 2023What Is Post-Finasteride Syndrome (PFS)? Is It Real? And What Is Its Prevalence?
Post-Finasteride Syndrome (PFS) is a term used to describe persistent sexual or cognitive side effects from finasteride, even months after quitting the medication. The existence of PFS is hotly debated amongst hair loss researchers, endocrinologists, and dermatologists. In this article, we’ll ...
By Perfect Hair Health TeamFeb 7, 2023If I Am Planning a Family, Should I Stop Taking Finasteride? (Men & Women)
Females using oral finasteride are advised to quit the drug at least one month before conceiving, as well as throughout pregnancy and breastfeeding. But what about men? The evidence is nuanced. Some clinicians claim that finasteride use for men during windows of conception poses no risk to a develop...
By Perfect Hair Health TeamJan 24, 2023Will Finasteride Lower My Libido?
Finasteride is widely regarded as the gold-standard treatment for male pattern hair loss, with 80-90% of men responding favorably to the drug. At the same time, the number one reason people avoid this hair loss medication is the fear of lower libido. Online reports of finasteride’s sexual side effec...
By Perfect Hair Health TeamJan 20, 2023Which Finasteride Is Best? A Look at Formulations
Finasteride is available in oral and topical formulations. Some hair loss sufferers opt for topicals, which have been touted as safe and effective by doctors and patients alike. Oral finasteride has stood the test of time and remains the gold standard for the treatment of male pattern hair loss. Whi...
By Perfect Hair Health TeamJan 15, 2023Can a Blood Test for Finasteride Determine the Risk of Side Effects?
Can blood tests reliably determine the risk of sexual side effects from hair loss drugs? Low-quality evidence (i.e., anecdotes and observational studies) suggest, in men, that low levels of free testosterone and/or high levels of sex hormone binding globulin are correlated with higher rates of sexua...
By Perfect Hair Health TeamJan 10, 2023How to Reduce the Risk of Finasteride Side Effects
Finasteride is an FDA-approved drug for androgenic alopecia. For a portion of men using finasteride, side effects can occur – most often in the form of sexual side effects, enlarged male breasts, lowered sperm counts, and erectile dysfunction. Fortunately, there are several strategies that can be em...
By Richard Clayton, PhDOct 25, 2022Finasteride For Women: What’s The Perfect Dose?
Oral finasteride is an effective treatment for male pattern hair loss, also known as androgenic alopecia. However, the drug’s benefits to female pattern hair loss are less clear. Some studies show that females taking between 1.0 to 5.0 mg of finasteride daily improve their hair loss, while oth...-
FREE RESOURCES
Research Tables
Want the latest research on Oral Finasteride? Every quarter, our research team conducts a literature search on Oral Finasteride to keep you up-to-date on new studies. See our search criteria & research tables below – including a summary of key findings from every single study.
Last updated: October 2024
Results
Search Criteria
Parameter
Inclusion Criteria
Exclusion Criteria
Patients Patients of any age with hair loss. Patients with no hair loss disorder. Intervention Oral finasteride as a standalone or adjunct therapy. A study that doesn’t contain oral finasteride either as a standalone or adjunct therapy Comparator Placebo and/or other therapies or baseline. No comparator. Outcomes Primary Endpoints of phototrichogram, investigator, and/or patient assessments. Any study not designed to adequately test for the standalone or additive effect of oral finasteride. Study Design Prospective, randomized controlled trials Literature reviews, non-human subjects, or ongoing clinical trials. Search Terms
Search Terms:
TOPICAL ALOPECIA FINASTERIDE ANDROGENETIC ANDROGENIC-
Abbreviations:
-
DHTDihydrotestosterone
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AGAAndrogenetic alopecia
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FPHLFemale pattern hair loss
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GPAGlobal photographic assessment
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FMXFinasteride and Minoxidil
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MXTTopical Minoxidil
Summarized Studies
Study Participants Design Treatment Results Key Takeaway Adverse Effects Eq Authors(year) Sex Hair Loss Type Design Dose Usage Duration Endpoints Hair Growth Assessments Summary Limitations Adverse Effects Jadad Score Inadomi (2014) n=37
Group 1: Hairy in areas other than the head
Group 2: Not hairy in areas other than the head.AGAPilot study Finasteride 1 mg Once daily 18.2 months Patient self-assessment Group 1: Finasteride was effective (excellent or good) in 88.9% of patients.
Group 2: Finasteride was effective (excellent or good) in 31.6% of patients.
Patients who are hairy in areas other than the head appear to respond better to finasteride. Small sample size, no objective observations. None reported 0Oliveira-Soares et al (2013) n=40 (F) Normoandrogenic postmenapausal women Prospective trial Finasteride 5 mg Once daily 18 months Patient satisfaction, GPA by two assessors with mean taken. Level of Improvement:
Major: 21
Moderate: 15
None: 4
Daily 5 mg finasteride treatment appears to be an effective and safe treatment for female AGA in postmenapuasal women. Small sample size, no objective observations. Libido reduction = 4
Increase in liver enzymes = 1
1Yeon (2011) n=87 (F) FPHLOpen-label clinical trial Finasteride 5 mg Once daily 12 months Phototrichogram (hair density and thickness), and GPA using a 7-point scale: greatly decreased ()3), moderately decreased()2), slightly decreased ()1), no change (0), slightly increased(+1), moderately increased (+2), greatly increase (+3) Hair Density: 90 hairs/cm2 at baseline to 107 hairs/cm2
Hair Thickness: 64 μm at baseline to 70 μm.
GPA: 57 patients were rated as ‘slightly increased’, 10 patients were rated as ‘moderately increased’ and 4 patients were rated as ‘greatly increased’.Oral finasteride at 5 mg/day may be an effective and safe treatment for normoandrogenic women with FPHL. No randomization or controlling (placebo or other comparator etc). Headache = 1 (led to withdrawal).
Headache, menstrual irregularity, dizziness, and increased body hair = 4
1Iorizzo et al (2006) n=37 (F) FPHLProspective Finasteride 2.5 mg + Oral contraceptive containing drospirenone 3 mg and ethinyl estradiol 30 μg Once daily 12 months Hair density, GPA, and patient self-assessment. Hair Density: Mean density of 4.5 at baseline increased to 4.8 at 12 months.
GPA: After 12 months, 62% of patients showed improvement in hair loss (32% slightly improved, 22% moderately improved, and 8% greatly improved).
Patient Self-Assessment: 29 patients judged their condition as improved, and 8 as stabilized.62% of patients demonstrated some improvement to their hair loss after using oral finasteride while taking the oral contraceptive. However, it is unclear whether the results are due to the finasteride or the contraceptive, which has an anti-androgenic effect. Small sample size, lack of randomization/blinding, and no placebo/comparator. No adverse effects were reported. 0Trueb (2004) n=5 (F) Postmenopausal women with FPHL Case-series Finasteride 2.5 mg (4 patient) or 5 mg (1 patient). Once daily Up to 19 months GPA, and Patient self-assessment Patient 1: Great improvement stated via GPA
Patient 2: Great improvement stated via GPA
Patient 3: Slight improvement or no change stated via GPA.
Patient 4: Moderate or slight improvement stated via GPA.
Patient 5: Slight improvement or no change stated via GPA.
All patients reported a slowing down of hair loss around 6 months after treatment, which continued until 12 months.
Oral finasteride in a dosage of 2.5 mg/day or more may be effective for the treatment of pattern hair loss in postmenopausal women. Case-series rather than a randomized controlled trial. Small sample size and no comparator. None reported. 0Arca et al (2004) n= 65 (M)
Group 1: 40
Group 2: 25AGAOpen, randomized, comparative study. Group 1: 1 mg oral finasteride.
Group 2: 5% MXTGroup 1: Once daily
Group 2: Twice daily12 months. GPA Group 1: 15% of patients saw dense hair growth, 30% saw moderate growth, 35% saw minimal growth, 18% saw no change, and 3% saw minimal loss.
Group 2: 16% of patients saw moderate growth, 36% saw minimal growth, 20% saw no change, 16% saw minimal loss, 8% saw moderate loss, and 4% saw dense loss.While both treatments appeared effective and safe, oral finasteride treatment was more effective at treating AGA in men than MXT. No placebo, lack of objective data collection. Group 1:
Loss of libido = 6
Increase in body hair = 1
Group 2:
Scalp irritation = 1
2Kaufman et al (1998) n=1553 (M)
Group 1: 779
Group 2: 774MPHL
Double-blind, placebo-controlled, randomized extension study. Group 1: 1 mg oral finasteride
Group 2:
Placebo
Once daily 12 months. Hair growth questionnaires& investigator assessments, GPA. Increase in Hairs:
Group 1: 11% increase in hairs.
Group 2: 2.7% decrease in hairs.
Patient self-assessment: Finasteride was deemed superior to the placebo as early as month 3 into the study.
Investigator Assessment:
Group 1: 65% of finasteride-treated patients were rated as improved by month 12.
Group 2: 37% of placebo-treated patients were rated as improved by month 12.
GPA:
Group 1: 48% of patients marked as improved by month 12.
Group 2: 7% of patients marked as improved by month 12.
Serum DHT:
Group 1: DHT reduced from 44.0 ng/dl at baseline to 14 ng/dl at month 12.
Testosterone increased from 510 ng/dl to 559 ng/dl at month 12.
In a clinical trial that spanned 2 years total, 1 mg daily of oral finasteride slowed the progression of hair loss and increased hair growth. None reported. Group 1: Decreased libido - 1.9%
Erectile dysfunction - 1.4%
Decreased ejaculate volume - 1%
Increase in body hair - 0.9%
Group 2:
Decreased libido - 1.3%
Erectile dysfunction - 0.9%
Decreased ejaculate volume - 0.4%
Increase in body hair - 0.9%
4
Kaufman et al (1998) - Extension of the above study. n=1215 (M)
MPHL
Double-blind, placebo-controlled, randomized extension study. Group 1: 1 mg oral finasteride
Group 2:
Placebo
Group 3: Finasteride - placebo
Group 4: Placebo - finasteride.Once daily 12 months. Hair growth questionnaires& investigator assessments, GPA. Increase in Hairs:
Groups 1 and 2: The combined analysis demonstrates a difference of 107 hairs between groups by month 12. At month 24, Group 1 maintained the hair counts whilstIn a clinical trial that spanned 2 years total, 1 mg daily of oral finasteride slowed the progression of hair loss and increased hair growth. None reported. Group 1: Decreased libido - 1.1%,
Erectile dysfunction - 0.7%,
Decreased ejaculate volume - 0.2%,
Increase in body hair - 0.2%.
Group 2:
Decreased libido - 1.7%,
Increase in body hair - 3%,
Urinary frequency - 1.7%,
Group 3:
Decreased libido - 1.3%,
Erectile dysfunction - 1.1%,
Increase in body hair - 0.7%.
Group 4: No adverse effects reported.4
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FREE RESOURCES
Research Tables
Want the latest research on Topical Finasteride? Every quarter, our research team conducts a literature search on Topical Finasteride to keep you up-to-date on new studies. See our search criteria & research tables below – including a summary of key findings from every single study.
Last updated: October 2024
Results
Search Criteria
Parameter
Inclusion Criteria
Exclusion Criteria
Patients Patients of any age with hair loss Patients with no hair loss disorder. Intervention Topical finasteride as a standalone or adjunct therapy. A study that doesn’t contain topical finasteride either as a standalone or adjunct therapy. Comparator Placebo and/or other therapies or baseline No comparator. Outcomes Primary Endpoints of phototrichogram, investigator, and/or patient assessments. Any study not designed to adequately test for the standalone or additive effect of topical finasteride. Study Design Prospective, observational, retrospective, and case series studies. Literature reviews, non-human subjects, or ongoing clinical trials. Search Terms
Search Terms:
topical alopecia finasteride androgenetic androgenic-
Abbreviations:
-
DHTDihydrotestosterone
-
AGAAndrogenetic alopecia
-
FPHLFemale pattern hair loss
-
GPAGlobal photographic assessment
-
FMXFinasteride and Minoxidil
-
MXTTopical Minoxidil
Summarized Studies
Study Participants Design Treatment Results Key Takeaway Adverse Effects Eq Authors(year) Sex Hair Loss Type Design Dose Usage Duration Endpoints Hair Growth Assessments Summary Limitations Adverse Effects Jadad Score Piraccini et al. (2022) n = 458
(M) Group 1: 189 Group 2: 184 Group 3: 85AGAPlacebo-controlled, double blind, randomized, prospective phase 3 study Group 1: 0.25% w/w finasteride.
Group 2: Topical placebo (same base as finasteride).
Group 3:
Oral finasteride (1 mg).
1-4 sprays of 50 µL once daily 24 weeks Photo-trichoscopy, GPA using a 7-point scale, patient self-assessment (male hair growth questionnaire). Hair Count: Group 1: Increase in 20.2 hairs
Group 2: 6.7
Group 3: 20.1
Hair Width: No change between treatments.
Patient self-assessment – No difference between treatments.
Change in Serum DHT:
Group 1: 34.5% reduction compared to baseline
Group 2: 2.25% increase.
Group 3: 55.6% reduction.Topical finasteride exhibited similar efficacy to oral finasteride for treating AGA, with a reduced change in serum DHT over the course of the study. Short-follow up. Patient discontinuation reasons – similar across all treatment groups (323 completed the study). 446 patients contributed safety data. 34% of discontinuations were mild, 18.4% moderate, and 2% severe. 2.8% of topical finasteride treated patients showed some sexual side effects without discontinuation. 5Suchonwanit et al (2019) n = 30 (F)
Group 1: 15 Group 2: 15.FPHLComparative, randomized, double-blind, prospective study. Group 1: 0.25% finasteride + 3% minoxidil (FMX).
Group 2: 3% minoxidil (MXT).
1 mL applied twice daily. 24 weeks Photo-trichoscopy, GPA using a 7-point rating scale, serum DHT. Hair Count: Increased with both treatments, but no statistical difference between the two groups (p = 0.88).
Hair Diameter: FMX -significantly increased compared to the MXT group (p = 0.02).
Serum DHT:
FMX group = 33% reduction in DHT (p = 0.016).
MXT group = 11% increase.
Combination finasteride and minoxidil exhibited higher efficacy than minoxidil alone. Small sample size, and short follow-up. Pruritis (n = 4, FMX); Irritation (n = 1, MXT). 4Suchonwanit et al. (2018) n = 40 (M)
Group 1: 20 Group 2: 20AGAComparative, double-blind, randomized prospective study. Group 1: 0.25% finasteride + 3% minoxidil (FMX).
Group 2: 3% minoxidil (MXT).
1 mL applied twice daily. 24 weeks Photo-trichoscopy, GPA using a 7-point rating scale, Serum DHT, patient self–assessment. Hairs per cm2: Group 1: 61.84 ± 15.65,
Group 2: 34.88 ± 10.24 (p = 0.05).
Hair diameter: Group 1: 17 ± 5.24µm,
Group 2: 13 ± 4.15µm (p = 0.05).
GPA: FMX performed better than MXT (p = 0.026) with 63.1% as marked improvement.
Patient self-assessment: 52.6% showed marked improvement with FMX.
Serum DHT:
Group 1: 5.7% reduction in DHT Group 2: 7.4% reduction (p = 0.92).
Treatment with FMX was significantly superior to MXT alone for promoting hair growth in AGA. No long-term follow-up and no evaluation of scalp DHT. No serious adverse events or sexual problems reported. Headache (n = 1 MXT); Dry flaky scalp (n = 3 FMX, n = 2 MXT). Pruritis (n = 2) 4Tanglertsampan, C. (2012) n = 40 (M)
Group 1: 20 Group 2: 20AGAComparative, double-blind, randomized, prospective study. Group 1: 0.1% topical finasteride (1 mg dose), combined with 3% minoxidil (FMX).
Group 2:
3% minoxidil (MXT).
1 mL applied twice daily 24 weeks Video dermoscopy for hair density. GPA using a 7-point rating scale Hair Count: No statistical difference in hair count between FMX group compared to the MXT group alone by week 24 (p = 0.503).
GPA:
Group 1: 1.84 ± 0.79
Group 2: 1.02 ± 0.69GPA assessment show significantly greater improvement in the FMX group compared to MXT alone. Small sample size, and short follow-up. Contact dermatitis
(n = 4 of 17, FMX;
n = 6 of 16, MXT).
No significant difference.
No sexual adverse effects.
4Hajheydari et al. (2009). n = 45 (M)
Seven were excluded
Group 1: 19
Group 2: 19AGAComparative, double-blind, randomized, prospective study. Group 1: 1% finasteride gel + placebo.
Group 2: 1 mg finasteride + placebo gel.Gel applied twice daily + 1 tablet (placebo or finasteride) taken once daily. 24 weeks Patient self-assessment, expert grading of bald spots, terminal hair count, and vellus hair. No statistical difference between oral and topical finasteride. Therapeutic effects of both finasteride gel and tablets were relatively similar to each other. Small sample size, and short, follow-up. Finasteride gel- Erythema (n = 1)
Finasteride oral - decreased libido (n = 1)
4Mazzarella et al. (1997) n = 52
28 (M)
24 (F) Group 1: 26 and Group 2: 26.AGAPlacebo-controlled, single-blind, non-randomized, prospective study.
Group 1: 0.005% finasteride.
Group 2: Placebo.1mL applied twice daily. 64 weeks Hair wash test and GPA using a 5-point scale, patient self–assessment using a 4-point scale. GPA: No significant regrowth for the first 3 months (scores between 1-2).
Group 1: score of 4 (n = 12) and 3 (n = 14).
Group 2: high rate of dropout (n = 10) due to lack of response – score of 2 (n = 3), score of 1 (n = 3), score of 0 (n = 4).
Wash Test: After 16 months - Group 1: count = 36.8 ± 8.1,
Group 2 = 54.2 ± 6.2. (p = <0.0001).
Self-assessment: Group 1:- 73% scored a 3, 27% scored a 2.
Group 2: 2 in one patient, 1 in three patients, and 0 in six patients.
The clinical outcome in terms of both hair growth and balding area reduction appeared encouraging - especially with no systemic effects observed. Small sample size. No adverse effects reported. 2 -
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FREE RESOURCES
Research Tables
Want the latest research on Mesotherapy Finasteride? Every quarter, our research team conducts a literature search on Mesotherapy Finasteride to keep you up-to-date on new studies. See our search criteria & research tables below – including a summary of key findings from every single study.
Last updated: October 2024
Results
Search Criteria
Parameter
Inclusion Criteria
Exclusion Criteria
Patients Patients of any age with hair loss. Patients with no hair loss disorder. Intervention Mesotherapy finasteride as a standalone or adjunct therapy. A study that doesn’t contain mesotherapy finasteride either as a standalone or adjunct therapy. Comparator Placebo and/or other therapies or baseline. No comparator. Outcomes Primary Endpoints of phototrichogram, investigator, and/or patient assessments. Any study not designed to adequately test for the standalone or additive effect of mesotherapy finasteride. Study Design Prospective, observational, retrospective, and case series studies. Literature reviews, non-human subjects, or ongoing clinical trials. Search Terms
Search Terms:
finasteride mesotherapy intradermal intralesional alopecia hair loss-
Abbreviations:
-
GPAGlobal Photographic Assessment
-
AGAAndrogenetic Alopecia
Summarized Studies
Study Participants Design Treatment Results Key Takeaway Adverse Effects Eq Authors(year) Sex Hair Loss Type Design Treatment Types Treatment Regimen Procedure No. of Sessions Duration Endpoints Hair Growth Assessments Summary Limitations Adverse Effects Jadad Score Talwar(2017) n=40
Group 1: 20
Group 2: 20AGAComparative trial. Mesotherapy finasteride and oral finasteride (1 mg). Group 1: Mesotherapy finasteride
Group 2: Oral finasteride (1 mg).Group 1: Topical finasteride injected with a mesotherapy needle using nappage technique.
Group 2: 1 mg oral finasteride daily.6 (Once every 2 weeks) 12 weeks + 6 months follow-up at after the last dose. GPA, patient satisfaction, hair pull tests. GPA:
Group 1: After 6 sessions 70% of participants were in the excellent improvement category for hair growth.
Group 2: After six sessions 60% of participants were in the excellent improvement category.
Patient self-assessment:
Group 1: Marked improvement = 60%
Group 2: Marked improvement = 60%.Mesotherapy with topical finasteride showed promise in the treatment of AGA in men. Small sample size. Group 1: Loss of libido (5%), folliculitis (2%).
Group 2: Loss of libido (10%), erectile dysfunction (5%).1 -
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AGA
FPHL
MPHL