The CRABP2 gene, which plays a role in retinoic acid metabolism, has been linked to hair health. Retinoic acid, a derivative of vitamin A, is known to influence hair growth, and some studies suggest CRABP2 may also be involved. However, the evidence connecting CRABP2 variants to hair loss and treatment effectiveness is still emerging. While … Read more
The BTD gene, responsible for encoding the enzyme biotinidase, is crucial for biotin metabolism. Biotin, or vitamin B7, plays a significant role in hair health, and biotinidase deficiency—caused by BTD polymorphisms—can lead to hair loss conditions like alopecia. While some studies suggest that biotin supplementation may benefit individuals … Read more
Can your genes predict the effectiveness of hormone therapy for hair loss? The CYP19A1 gene, which encodes the enzyme aromatase, has been linked to hair growth and hair loss, particularly in androgenetic alopecia (AGA). Some studies suggest that certain CYP19A1 variants might influence the effectiveness of hair loss treatments by modulating levels … Read more
The COL1A1 gene, responsible for producing a key component of type 1 collagen, has been associated with hair growth and structure. Certain genetic variations in COL1A1 might affect the balance of collagen chains, potentially influencing hair loss and the response to treatments. However, the current evidence is limited, and while there is some … Read more
2dDR Hair introduces two hair care products featuring 2-deoxy-D-ribose (2dDR), a naturally occurring sugar, claiming it can support hair regrowth. While a recent mouse study suggests promising results, there is currently no clinical evidence in humans to support its effectiveness or safety. This review examines the science behind 2dDR, evaluates … Read more
This article explores the potential link between angiotensin-converting enzyme (ACE) activity and hair loss, particularly in the context of androgenic alopecia (AGA) and alopecia areata (AA). While ACE plays a crucial role in blood pressure regulation and vasoconstriction, there is limited evidence supporting its direct influence on hair loss or … Read more
The NR3C1 gene codes for the glucocorticoid receptor, a key player in the regulation of metabolism, immune response, and stress adaptation. Variations in the NR3C1 gene, such as the rs6198 SNP, have been linked to differences in glucocorticoid sensitivity with some variants leading to increased expression of the GRβ isoform. While some companies … Read more
Can your genes predict the effectiveness of PGF2α analogs for hair loss? The PGFTR gene, encoding the prostaglandin F2 alpha (PGF2α) receptor, is a potential target in hair loss treatment. Prostaglandin F2α and its analogs like latanoprost have been shown to stimulate hair follicle growth, making PGTFR a potential target. Although research has … Read more
The PTGES2 gene encodes the enzyme prostaglandin E synthase 2, which is crucial for converting prostaglandin H2 to prostaglandin E2 (PGE2). This enzyme plays a significant role in various physiological processes, including inflammation and hair growth. Research has indicated that an SNP in the PTGES2 gene is associated with PGE2 synthase activity … Read more
The IGF1R gene encodes the insulin-like growth factor-1 receptor, which is integral to the IGF signaling pathway, particularly in processes like growth and development. Variations in the IGF1R gene, such as the rs2229765 polymorphism, have been linked to differences in circulating IGF-1 levels, with specific genotypes showing reduced IGF-1 levels. … Read more