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Explore the science behind hair loss and hair growth. Our in-depth articles cover topics ranging from natural remedies to pharmaceuticals to breakthroughs in hair loss science. Want to request an article topic? Contact us.

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BTD: Can This Gene Predict Regrowth From Biotin?
By Ben Fletcher, PhD
Sep 8, 2024

BTD: Can This Gene Predict Regrowth From Biotin?

The BTD gene, responsible for encoding the enzyme biotinidase, is crucial for biotin metabolism. Biotin, or vitamin B7, plays a significant role in hair health, and biotinidase deficiency—caused by BTD polymorphisms—can lead to hair loss conditions like alopecia. While some studies suggest that biot...
COL1A1: Can This Gene Predict Regrowth From Collagen Support?
By Ben Fletcher, PhD
Sep 4, 2024

COL1A1: Can This Gene Predict Regrowth From Collagen Support?

The COL1A1 gene, responsible for producing a key component of type 1 collagen, has been associated with hair growth and structure. Certain genetic variations in COL1A1 might affect the balance of collagen chains, potentially influencing hair loss and the response to treatments. However, the current ...
2dDR For Hair Loss: What Do We Know So Far About This Sugar?
By Sarah King, PhD
Sep 4, 2024

2dDR For Hair Loss: What Do We Know So Far About This Sugar?

2dDR Hair introduces hair care products featuring 2-deoxy-D-ribose (2dDR), a naturally occurring sugar, claiming it can support hair regrowth. While a recent mouse study shows favorable results, there is currently no clinical evidence in humans to support its effectiveness or safety. In fact, after ...
CYP19A1: Can This Gene Predict Regrowth From Hormone Therapy?
By Ben Fletcher, PhD
Sep 4, 2024

CYP19A1: Can This Gene Predict Regrowth From Hormone Therapy?

Can your genes predict the effectiveness of hormone therapy for hair loss? The CYP19A1 gene, which encodes the enzyme aromatase, has been linked to hair growth and hair loss, particularly in androgenetic alopecia (AGA). Some studies suggest that certain CYP19A1 variants might influence the effective...
ACE: Can This Gene Predict Regrowth From Treatments Targeting Blood Flow?
By Ben Fletcher, PhD
Aug 27, 2024

ACE: Can This Gene Predict Regrowth From Treatments Targeting Blood Flow?

This article explores the potential link between angiotensin-converting enzyme (ACE) activity and hair loss, particularly in the context of androgenic alopecia (AGA) and alopecia areata (AA). While ACE plays a crucial role in blood pressure regulation and vasoconstriction, there is limited evidence ...
NR3C1: Can This Gene Predict Responsiveness to Glucocorticoids?
By Sarah King, PhD
Aug 21, 2024

NR3C1: Can This Gene Predict Responsiveness to Glucocorticoids?

The NR3C1 gene codes for the glucocorticoid receptor, a key player in the regulation of metabolism, immune response, and stress adaptation. Variations in the NR3C1 gene, such as the rs6198 SNP, have been linked to differences in glucocorticoid sensitivity with some variants leading to increased expr...
PTGES2: Can This Gene Predict Regrowth from Minoxidil?
By Sarah King, PhD
Aug 21, 2024

PTGES2: Can This Gene Predict Regrowth from Minoxidil?

The PTGES2 gene encodes the enzyme prostaglandin E synthase 2, which is crucial for converting prostaglandin H2 to prostaglandin E2 (PGE2). This enzyme plays a significant role in various physiological processes, including inflammation and hair growth. Research has indicated that an SNP in the PTGES...
PGTFR: Can This Gene Predict Regrowth From PGF2a Analogs?
By Sarah King, PhD
Aug 21, 2024

PGTFR: Can This Gene Predict Regrowth From PGF2a Analogs?

Can your genes predict the effectiveness of PGF2α analogs for hair loss? The PGFTR gene, encoding the prostaglandin F2 alpha (PGF2α) receptor, is a potential target in hair loss treatment. Prostaglandin F2α and its analogs like latanoprost have been shown to stimulate hair follicle growth, making PG...
IGF1R: Can This Gene Predict Regrowth From IGF-1?
By Ben Fletcher, PhD
Aug 20, 2024

IGF1R: Can This Gene Predict Regrowth From IGF-1?

The IGF1R gene encodes the insulin-like growth factor-1 receptor, which is integral to the IGF signaling pathway, particularly in processes like growth and development. Variations in the IGF1R gene, such as the rs2229765 polymorphism, have been linked to differences in circulating IGF-1 levels, with...
SRD5A1 & 2: Can These Genes Predict Regrowth From 5-Alpha-Reductase Inhibitors?
By Ben Fletcher, PhD
Aug 6, 2024

SRD5A1 & 2: Can These Genes Predict Regrowth From 5-Alpha-Reductase Inhibitors?

Can your genes predict the effectiveness of 5α-reductase inhibitors for hair loss? The SRD5A1 and SRD5A2 genes, encoding type I and type II 5α-reductase respectively, are central to DHT production, a key factor in the pathogenesis of androgenic alopecia. Genetic testing companies suggest certain SR5...

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