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Learn MoreIn a recent milestone, a drug called ritlecitinib (brand name Litfulo™) was approved for treating alopecia areata (AA) in adolescents and adults. But is there high quality evidence supporting ritlecitinib? What are the long-term safety risks? And if it works, does this (relatively) new medication require lifelong use to prevent relapses of alopecia areata? In this article, we’ll discuss the science behind this hair loss drug.
In a recent milestone, a drug called ritlecitinib (brand name Litfulo™) has been approved for treating alopecia areata (AA) in adolescents and adults. Ritlecitinib is a type of drug classified as a kinase inhibitor.[1]Pfizer, (2023), FDA Approves Pfizer’s LITFULO™ (Ritlecitinib) for Adults and Adolescents with Severe Alopecia Areata. Pfizer. Available at: … Continue reading In this article, we are going to explore how ritlecitinib works, its safety and efficacy, and its implications for treating hair loss.
Ritlecitinib is a small-molecule inhibitor of the enzyme janus-associated kinase (JAK) that was approved in the US in June 2023. [6]Ramirez-Marin & Tosti (2022), Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata. Drug Design, Development and Therapy. 16. 363-374. Available at: … Continue reading Over a year ago, another JAK inhibitor, baricitinib, was approved last year for severe AA. Now, there’s a second FDA-approved drug for this hair loss disorder, and of a similar class for its mechanisms of action.
The recommended dose of ritlecitinib is 50 mg orally once a day with or without food.[7]{Pfizer, (no date), LITFULO Medical Information. Pfizer. Available at: https://www.pfizermedicalinformation.com/en-us/litfulo/boxed-warning (Accessed: 14 September 2023)
Ritlecitinib comes under a class of drugs called Janus kinase (JAK) inhibitors. This is because it selectively inhibits a specific enzyme in the JAK family called JAK3. JAK3 is part of a cell signaling pathway called the JAK/STAT pathway, which transmits signals from outside the cell to the nucleus to regulate the expression of genes. This pathway is involved in the control of processes such as the maintenance of stem cells, the formation of new blood cells, and the inflammatory response.[9]Thomas, S.J., Snowden, J.A., Zeidler, M.P., and Danson, S.J. (2015), The role of JAK/STAT signaling in the pathogenesis, prognosis and treatment of solid tumors. British Journal of Cancer. 113. … Continue reading
The JAK/STAT pathway is activated by a range of growth factors and other signaling molecules, including a group of substances called cytokines. Cytokines are proteins that can modulate the immune system in different ways, depending onthe context.[10]Broussard, G., Damania, B. (2020), KSHV: Immune Modulation and Immunotherapy. Frontiers in Immunology. 10. 1-8. Available at: https://doi.org/10.3389/fimmu.2019.03084
In our article on baricitinib, we talk about the JAK/STAT pathway and how cytokine receptors can be described as transmembrane receptors – the receptors cross the cell membrane and have sections that can be found inside and outside the cell. The binding of the cytokine to the receptor on the outside of the cell causes a protein called JAK to bind to the inside portion of the receptor, leading it to undergo a process called trans-phosphorylation, in which a phosphate group is transferred from the receptor to the JAK protein(Figure 2).[11]Harrison, J.A. (2012), The JAK/STAT Pathway. Cold Spring Harbor Perspectives in Biology. 4(3). 1-3. Available at: https://doi.org/10.1101/cshperspect.a011205
These JAK proteins, in turn, activate other pathways by phosphorylating proteins like the STATs (signal transducer and activator of protein transcription). When activated by JAK phosphorylation, STAT proteins undergo a change in shape, which allows them to move to the nucleus (called translocation), where they can then activate or deactivate specific genes involved in several cellular processes.[13]Awasthi, N., Liongue, C., Ward, A.C. (2021), STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer. Journal of Hematology & Oncology. 14(198). 1-17. … Continue reading
The response to JAK/STAT pathway activation can be different across different types of cells and tissue, depending on the specific type of proteins that make up the pathway and what other signaling pathways are operating in that cell. This provides a contextual element to JAK/STAT signaling.[14]Harrison, D.A., The JAK/STAT Pathway. Cold Spring Harbor Perspectives in Biology. 4(3). A011205. Available at: https://doi.org/10.1101/cshperspect.a011205
The short answer: activation of the JAK/STAT pathway leads to hair loss caused by immune system activation.
How does AA develop? Let’s recap. Our hair follicles have something called ‘immune privilege’ – they are less subject to the immune response than most of the other areas of the body. This is thought to be in place to protect the stem-cell-containing area of the hair follicle, known as the bulge, which is required for new hair follicle growth in the hair cycle.[15]Azzawi, S., Penzi, L.R., Senna, M.M. (2018), Immune Privilege Collapse and Alopecia Development: Is Stress a Factor. Skin Appendage Disorders. 4(4).236-244. Available at: … Continue reading In AA, something triggers a breakdown of the immune privilege of the hair follicle. The exact cause of this breakdown is not fully understood, but it may involve genetic factors, environmental triggers, or a combination of both.
When the immune privilege is compromised, a group of immune cells called T cells begin to attack the hair follicle. As mentioned earlier, the JAK/STAT pathway plays a critical role in transmitting signals within cells. When the immune system attacks hair follicles, the JAK/STAT pathway is activated, sending signals instructing cells to participate in the attack. As a result, the cells around the hair follicles respond to these signals by causing inflammation and damaging the hair follicle. This disrupts the normal hair growth cycle and leads to hair loss in the affected areas (Figure 3).[16]Kumar, N., Kuang, L., Villa, R., Kumar, P., Mishra, J. (2021), Mucosal Epithelial Jak Kinases in Health and Diseases. Mediators of Inflammation. 1-17. https://doi.org/10.1155/2021/6618924
JAK3 is particularly important in the development and function of T cells.[18]Sohn, S.J., Forbush, K.A., Nguyen, N., Witthuhn, B., Nosaka, T., Ihie, J.N., Perimutter, R.M. (1998). Requirement for JAK3 in mature T cells: Its role in regulation of T cell homeostasis. The Journal … Continue reading By targeting JAK3, ritlecitinib may help inhibit T cell activity without affecting other immune cells as strongly. This targeted approach may help to reduce the autoimmune response while preserving some aspects of the immune system’s ability to fight infections.[19]Dai, Z., Sezin, T., Chang, Y., Lee, E.Y., Wang, E.H.C., Christiano, A.M. (2022), Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata. Frontiers in Immunology. 13. … Continue reading
Furthermore, Targeting JAK3 may provide a more precise therapeutic approach for AA. Since JAK3 is primarily involved in immune responses mediated by certain subsets of T cells, it could potentially lead to fewer off-target effects on other immune system functions. Of course, this precision is desirable to avoid compromising the immune system’s ability to protect against infections. Inhibiting JAK1/2 may have broader effects on the immune system, potentially leading to more significant side effects. For example, JAK1/2 inhibitors might interfere with the body’s response to infections or impact other physiological processes.[20]Sardana, K., Bathula, S., Khurana, A. (2023), Which is the Ideal JAK Inhibitor for Alopecia Areata – Baricitinib, Tofacitinib, Ritlecitinib, or Ifidancitinib – Revisiting the … Continue reading By specifically targeting JAK3, the goal is to minimize unwanted side effects while still addressing the autoimmune component of the AA disease mechanism.
Several clinical trials have either already been carried out using ritlecitinib or are ongoing. These trials have been conducted in adults, adolescents, and children, either with AA or cicatricial alopecia (which is similar to AA in terms of disease mechanism, although there are important differences). In total, we could find 2 completed clinical trials with a total number of patients included being 789. We will also cover one of the studies that were conducted at the same time as these trials with the same patients.
The first study was a phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of ritlecitinib and a similar drug, brepocitinib, in AA.[21]King, B., Guttman-Yassky, E., Peeva, E., Banerjee, A., Sinclair, R., Pavel, A.B., Zhu, L., Cox, L.A., Craiglow, B., Chen, L., Banfield, C., Page, K., Zhang, W., Vincent, M.S. (2021). A phase 2a … Continue reading 142 participants took part (98 female and 44 male) with an average age of 36. Participants were treated with 200 mg of ritlecitinib or 60 mg of baricitinib once daily for four weeks. Then, they were treated with a maintenance dose of 50 mg (ritlecitinib) or 30 mg (baricitinib) for the next 20 weeks. The results were promising for patients with AA who started the study with over 50% of scalp hair loss. Both medications resulted in significant hair regrowth, with 25% (ritlecitinib group) and 34% (baricitinib group) of patients achieving near-complete hair regrowth as measured by Severity of Alopecia Tool (SALT90) scores compared to the placebo group (Figure 4).
The SALT tool is validated for measuring the extent of hair loss in AA with 0% meaning no hair loss, and 100% meaning complete hair loss (with several grades in between).[22]Wyrwich, K.W., Kitchen, H., Knight, S., Aldhouse, N.V.J., Macey, J., Nunes, F.P., Dutronc, Y., Mesinkovska, N., Ko, J.M., King, B.A. (2020). The Alopecia Areata Investigator Global Assessment Scale: … Continue reading The SALT90 score, however, measures the percentage of people who achieved at least 90% of hair regrowth.
Adverse events were reported in all three treatment groups, with common events including upper respiratory tract infection, nasopharyngitis, headache, acne, and nausea. Serious adverse events were only noted in the brepocitinib group, which could indicate that it may induce more hair regrowth than ritlecitinib but may not be as safe to use.
So, to summarize, although brepocitinib performed better, ritlecitinib also improved hair regrowth scores in patients with AA and appeared to be better tolerated than brepocitinib.
This particular clinical trial also contained a further sub-study to further evaluate the efficacy and safety of ritlecitinib and brepocitinib.[24]Guttman-Yasky, E., Pavel, A.B., Diaz, A., Zhang, N., Duca, E.D., Estrada, Y., King, B., Banarjee, A., Banfield, C., Cox, L.A., Dowty, M.E., Page, K., Vincent, M.S., Zhang, W., Zhu, L., Peeva, E. … Continue reading The study involved taking scalp biopsy samples from patients with AA at baseline and analyzing changes in specific biomarkers between baseline and weeks 12 and 24 of treatment.
Ritlecitinib significantly shifted gene expression in the scalp towards an improved, non-lesional profile. This improvement exceeded 100% of baseline at week 24, indicating a strong positive response to the treatment. Furthermore, the treatment led to a downregulation of inflammatory markers associated with T cells, T cell activation, and other immune response markers. These changes also correlated with an improvement in the SALT score (Figure 5).
However, the most recent study (just prior to ritlecitinib becoming FDA approved) was a 48-week phase 2b/3 randomized, double-blind, placebo-controlled clinical trial.[26]King, B., Zhang, X., Harcha, W.G>, Szepietowski, J.C., Shapiro, J., Lynde, C., Mesinkovska, N.A., Zwillich, S.H., Napatalung, L., Wajsbrot, D., Fayyad, R., Freyman, A., Mitra, D., Purohit, V., … Continue reading The trial was conducted across118 sites in 18 countries, with 718 patients (446 women, 272 men) aged 12 years and older with alopecia areata and at least 50% scalp hair loss – as measured by SALT severity scores.
The patients were assigned to either an oral ritlecitinib or placebo treatment, given once daily for 24 weeks. Several doses of ritlecitinib were tested, along with a variable 4-week loading dose and were followed by a 24-week extension period, during which the ritlecitinib group continued their treatment, and the placebo-treated group switched to ritlecitinib (Figure 6).
The researchers found that patients on the 30 mg or 50 mg doses of ritlecitinib exhibited the highest regrowth scores, and including a loading dose resulted in further improvement. Response rates based on a SALT score of 20% or less at week 24 were significantly higher in ritlecitinib groups compared to the placebo (Figure 7A):
The response rates, based on a SALT score of 10 or less at week 24, were also significantly higher in ritlecitinib groups compared to the placebo (Figure 7B). Furthermore, the proportion of patients with a Patient Global Impression of Change (PGI-C) response of moderately or greatly improved was greater with ritlecitinib treatment compared to placebo at week 24 (Figure 7C). The PGI-C reflects a patient’s belief about the efficacy of a treatment.[28]Ferguson, L., Scheman, J. (2009). Patient global impression of change scores within the chronic pain rehabilitation program. The Journal of Pain. 10(4). S73. Available at: … Continue reading Regrowth of eyelashes and eyebrows was also observed with ritlecitinib treatment (Figures 7D/7E), with responses continuing up to week 48 in all ritlecitinib groups.
So, to summarize, ritlecitinib was effective in promoting hair regrowth and was generally well tolerated (more on that below) in patients with alopecia areata. There is a longer-term efficacy study currently ongoing called ALLEGRO-LT, which aims to evaluate the safety and efficacy of ritlecitinib over a period of 60 months (5 years).[30]Clinical Trials (2023) Long-term PF-06651600 for the Treatment of Alopecia Areata (ALLEGRO-LT). NIH. Available at: … Continue reading This trial is due to finish in 2026 and will hopefully provide the long-term efficacy and safety data that is needed.
The overall safety profile was observed throughout the study, and it was determined that ritlecitinib was generally well-tolerated across all doses and showed a favorable safety profile. The most common adverse effects (occurring in at least 10% of patients in any treatment group) included:
A total of 16 more serious adverse events were reported in 14 patients. These included:
Treatment with ritlecitinib also led to changes in hematological parameters, including:
So 14/718 patients experienced a more serious adverse effect – so roughly 2% of patients, or 1 in 50. While you may consider these ‘good odds’, it is important to consider these potential adverse effects when making a treatment decision and always consult a physician.
Ritlecitinib is an exciting new treatment; however, it is important to remember that it is for the treatment of severe alopecia areata only and will not work for other hair loss types like androgenetic alopecia, as the mechanisms of hair loss are very different. You may want to try this treatment if:
References[+]
↑1 | Pfizer, (2023), FDA Approves Pfizer’s LITFULO™ (Ritlecitinib) for Adults and Adolescents with Severe Alopecia Areata. Pfizer. Available at: https://www.pfizer.com/news/press-release/press-release-detail/fda-approves-pfizers-litfulotm-ritlecitinib-adults-and (Accessed: 14 September 2023) |
---|---|
↑2, ↑23 | King, B., Guttman-Yassky, E., Peeva, E., Banerjee, A., Sinclair, R., Pavel, A.B., Zhu, L., Cox, L.A., Craiglow, B., Chen, L., Banfield, C., Page, K., Zhang, W., Vincent, M.S. (2021). A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results. Journal of the American Academy of Dermatology. 85(2). 379-387. Available at: https://doi.10.1016/j.jaad.2021.03.050 |
↑3 | King, B., Zhang, X., Harcha, W.G., Szepietowski, J.C., Shapiro, J., Lynde, C., Mesinkovska, N.A., Zwillich, S.H., Napatalung, L., Wasjsbrot, D., Fayyad, R., Freyman, A., Mitra, D., Purohit, V., Sinclair, R., Wolk, R. (2023). Efficacy and Safety of Ritlecitinib in adults and adolescents with alopecia areata: a randomized, double-blind, multicentre, phase 2b-3 trial. The Lancet. 401. 1518-1529. Available at: https://doi.org/10.1016/S0140-6736(23)00222-2 |
↑4, ↑24, ↑25 | Guttman-Yasky, E., Pavel, A.B., Diaz, A., Zhang, N., Duca, E.D., Estrada, Y., King, B., Banarjee, A., Banfield, C., Cox, L.A., Dowty, M.E., Page, K., Vincent, M.S., Zhang, W., Zhu, L., Peeva, E. (2022), Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers. Atopic Dermatitis and Inflammatory Skin Disease. 149(4). P1318-1328. Available at: https://doi.org/10.1016/j.jaci.2021.10.036 |
↑5 | LITFULO, (2023). Highlights of prescribing information. LITFULO. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/215830s000lbl.pdf (Accessed: 18 September 2023) |
↑6 | Ramirez-Marin & Tosti (2022), Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata. Drug Design, Development and Therapy. 16. 363-374. Available at: https://doi.org/10.2147/DDDT.S334727 |
↑7 | {Pfizer, (no date), LITFULO Medical Information. Pfizer. Available at: https://www.pfizermedicalinformation.com/en-us/litfulo/boxed-warning (Accessed: 14 September 2023) |
↑8 | Selleckchem (no date), Ritlecitinib. Selleckchem. Available at: https://www.selleckchem.com/products/pf-06651600.html (Accessed: 15 September 2023) |
↑9 | Thomas, S.J., Snowden, J.A., Zeidler, M.P., and Danson, S.J. (2015), The role of JAK/STAT signaling in the pathogenesis, prognosis and treatment of solid tumors. British Journal of Cancer. 113. 365-371. Available at: https://doi.org/10.1038/bjc.2015.233 |
↑10 | Broussard, G., Damania, B. (2020), KSHV: Immune Modulation and Immunotherapy. Frontiers in Immunology. 10. 1-8. Available at: https://doi.org/10.3389/fimmu.2019.03084 |
↑11 | Harrison, J.A. (2012), The JAK/STAT Pathway. Cold Spring Harbor Perspectives in Biology. 4(3). 1-3. Available at: https://doi.org/10.1101/cshperspect.a011205 |
↑12 | Luo, W., Li, Y.W., Jiang, L.J., Chen, Q., Wang, T., Ye, D.W. (2020). Targeting JAK-STAT signaling to Control Cytokine Release Syndrome in COVID-19. Trends in Pharmacological Sciences. 8. 531-543. Available at: https://doi.org/10.1016/kj.tips.2020.06.007 |
↑13 | Awasthi, N., Liongue, C., Ward, A.C. (2021), STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer. Journal of Hematology & Oncology. 14(198). 1-17. https://doi.org/10.1186/s13045-021-01214-y |
↑14 | Harrison, D.A., The JAK/STAT Pathway. Cold Spring Harbor Perspectives in Biology. 4(3). A011205. Available at: https://doi.org/10.1101/cshperspect.a011205 |
↑15 | Azzawi, S., Penzi, L.R., Senna, M.M. (2018), Immune Privilege Collapse and Alopecia Development: Is Stress a Factor. Skin Appendage Disorders. 4(4).236-244. Available at: https://doi.org/10.1159/0000485080 |
↑16 | Kumar, N., Kuang, L., Villa, R., Kumar, P., Mishra, J. (2021), Mucosal Epithelial Jak Kinases in Health and Diseases. Mediators of Inflammation. 1-17. https://doi.org/10.1155/2021/6618924 |
↑17 | Lensin, M., Jabbari, A. (2022), An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata. Frontiers in Immunology. 13. 1-17. Available at: https://doi.org/10.3389/fimmu.2022.955035 |
↑18 | Sohn, S.J., Forbush, K.A., Nguyen, N., Witthuhn, B., Nosaka, T., Ihie, J.N., Perimutter, R.M. (1998). Requirement for JAK3 in mature T cells: Its role in regulation of T cell homeostasis. The Journal of Immunology. 160(5). 2130-2138. Available at: https://doi.org/10.4049/jimmunol.160.5.2130 |
↑19 | Dai, Z., Sezin, T., Chang, Y., Lee, E.Y., Wang, E.H.C., Christiano, A.M. (2022), Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata. Frontiers in Immunology. 13. 1-14. Available at: https://doi.org/10.3389/fimmu.2022.955038 |
↑20 | Sardana, K., Bathula, S., Khurana, A. (2023), Which is the Ideal JAK Inhibitor for Alopecia Areata – Baricitinib, Tofacitinib, Ritlecitinib, or Ifidancitinib – Revisiting the Immunomechanisms of the JAK Pathway. Indian Dermatology Online Journal. 14. 465-474. Available at: https://doi.org/10.4103/idoj.idoj_452_22 |
↑21 | King, B., Guttman-Yassky, E., Peeva, E., Banerjee, A., Sinclair, R., Pavel, A.B., Zhu, L., Cox, L.A., Craiglow, B., Chen, L., Banfield, C., Page, K., Zhang, W., Vincent, M.S. (2021). A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results. Journal of the American Academy of Dermatology. 85(2). 379-387. Available at: https://doi.org/10.1016/j.jaad.2021.03.050 |
↑22 | Wyrwich, K.W., Kitchen, H., Knight, S., Aldhouse, N.V.J., Macey, J., Nunes, F.P., Dutronc, Y., Mesinkovska, N., Ko, J.M., King, B.A. (2020). The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials. 183(4). 702-709. Available at: https://doi.org/10.1111/bjd.18883 |
↑26 | King, B., Zhang, X., Harcha, W.G>, Szepietowski, J.C., Shapiro, J., Lynde, C., Mesinkovska, N.A., Zwillich, S.H., Napatalung, L., Wajsbrot, D., Fayyad, R., Freyman, A., Mitra, D., Purohit, V., Sinclair, R., Wolk, R. (2023). Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomized, double-blind, multicentre, phase 2b-3 trial. The Lancet. 401(10387). 1518-1529. Available at: https://doi.org/10.1016/S0140-6736(23)002222-2 |
↑27, ↑29 | King, B., Zhang, X., Harcha, W.G., Szepietowski, J.C., Shapiro, J., Lynde, C., Mesinkovska, N.A., Zwillich, S.H., Napatalung, L., Wasjsbrot, D., Fayyad, R., Freyman, A., Mitra, D., Purohit, V., Sinclair, R., Wolk, R. (2023). Efficacy and Safety of Ritlecitinib in Adults and Adolescents with Alopecia Areata: a Randomized, Double-Blind, Multicentre, Phase 2b-3 Trial. The Lancet. 401. 1518-1529. Available at: https://doi.org/10.1016/S0140-6736(23)00222-2 |
↑28 | Ferguson, L., Scheman, J. (2009). Patient global impression of change scores within the chronic pain rehabilitation program. The Journal of Pain. 10(4). S73. Available at: https://doi.org/10.1016/j.pain.2009.01.258 |
↑30 | Clinical Trials (2023) Long-term PF-06651600 for the Treatment of Alopecia Areata (ALLEGRO-LT). NIH. Available at: https://clinicaltrials.gov/study/NCT04006457?term=ALLEGRO-LT&checkSpell=false&rank=1 (Accessed: 18 September 2023) |
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Learn MoreDr. Sarah King is a researcher & writer who holds a BSc in Medical Biology, an MSc in Forensic Biology, and a Ph.D. in Molecular and Cellular Biology. While at university, Dr. King’s research focused on cellular aging and senescence through NAD-dependent signaling – along with research into prostaglandins and their role in hair loss. She is a co-author on several upcoming manuscripts with the Perfect Hair Health team.
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